DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and Abca4

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_031404.1	Gene:	Abca4 / 11304	MGIID:	109424	Length:	2310	Species:	Mus musculus

Alignment Length:	976	Identity:	188/976 - (19%)
Similarity:	338/976 - (34%)	Gaps:	329/976 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLG 112
            |||:...|::..|..|.|  |.||:|..:..|...||.:|.||||.||.:.|.....||.: ::|
Mouse   929 VCVKNLVKVFEPSGRPAV--DRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTV-LIG 990

  Fly   113 GRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLPN-A 176
            |:.......|....:|..||...|:...|:.|.::::..:...|..:.:...|.:|:...|.: .
Mouse   991 GKDIETNLDVVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEAQLEMEAMLEDTGLHHKR 1055

  Fly   177 SKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTH 241
            ::..::||||.||::|:|:|.:.:.::::|||||.||||..|:||||.|:.. ::|. |:|::||
Mouse  1056 NEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKY-RSGR-TIIMSTH 1118

  Fly   242 YIDECAQAHMIG----LLRGGKMLAEESPDYLRQQYNADSLEDVFLKLSVLQ------------- 289
            ::||   |.::|    ::..|::....:|.:|:..:.......:..|:..:|
Mouse  1119 HMDE---ADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRGGCEGVCSCT 1180

  Fly   290 --------------------------------------------------------NMGKRRRSS 298
                                                                    |..:|..:|
Mouse  1181 SKGFSTRCPTRVDEITEEQVLDGDVQELMDLVYHHVPEAKLVECIGQELIFLLPNKNFKQRAYAS 1245

  Fly   299 IAQEIVEQVTVPAISNPALDMSD---EQHAAEISGEFGDNISMSSAA---------RDPISTTA- 350
            :.:|:.|  |:..:...:..:||   |:...:::.:.|........|         |.|.|...
Mouse  1246 LFRELEE--TLADLGLSSFGISDTPLEEIFLKVTEDAGAGSMFVGGAQQKREQAGLRHPCSAPTE 1308

  Fly   351 -------------------PAAPPLPPPQE--IPTSFWYNLHVMQSHHLHALIWKNFLWMMRN-- 392
                               |...|.|.|::  :|.:....| ::|  |:.||:.|.|...:|:
Mouse  1309 KLRQYAQAPHTCSPGQVDPPKGQPSPEPEDPGVPFNTGARL-ILQ--HVQALLVKRFHHTIRSRK 1370

  Fly   393 --------------VGVMLFIVGLPVVQ---ILLFCYAIGHDPTGLKLAVANHE----------- 429
                          :.:||.|:..|..:   :.|..:..||..|...:...|:|
Mouse  1371 DFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQYTFFSMDEPNNEHLEVLADVLLN 1435

  Fly   430 ---MSGEMIMEQFCPVHTGCNQT-----MLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAW 486
               .....:.|::.|.:...|.|     .:|.....:..|.|                      |
Mouse  1436 RPGFGNRCLKEEWLPEYPCINATSWKTPSVSPNITHLFQKQK----------------------W 1478

  Fly   487 AALVIQPNYTASLMERV---------EDGRYAEDGTIESSDLAVRMDWSNQQISQLLYRDLQYTF 542
            .|....|:...|..|::         ..|......|..|::  |..|.:|:.||..|.:    |:
Mouse  1479 TAAHPSPSCKCSTREKLTMLPECPEGAGGLPPPQRTQRSTE--VLQDLTNRNISDYLVK----TY 1537

  Fly   543 FNFVGDMLSD-----------CDVNPKLGRVPVDFQ-----------------HPVYGYRNPNFT 579
            ...:...|..           ..:..||..:|:..:                 .||....:....
Mouse  1538 PALIRSSLKSKFWVNEQRYGGISIGGKLPAIPISGEALVGFLSGLGQMMNVSGGPVTREASKEML 1602

  Fly   580 DF-----AAPGVIL--------TIIFFLAV---AVTSGAMLIDRNEGMLERCLVAGITGPEILLS 628
            ||     ....:.:        .::.||.|   |:...::..||:.   |...:..|:.|..|..
Mouse  1603 DFLKHLETTDNIKVWFNNKGWHALVSFLNVAHNAILRASLPRDRDP---EEYGITVISQPLNLTK 1664

  Fly   629 QVVTQFTVMLSQTTFVLIVSFYFFELTLVGNIWLVVALCILNGLCGMSFGFVISCAVDTERTATY 693
            :.::..||:   ||                ::..|||:|::..:..:...||:....:....|.:
Mouse  1665 EQLSDITVL---TT----------------SVDAVVAICVIFAMSFVPASFVLYLIQERVTKAKH 1710

  Fly   694 VAMGSFLPIVMLCGIIWPIEGMFPLLQFFTAFL-----------------------PLTKPTE-- 733
            :..               |.|:.|...:.|.||                       ..|.|..
Mouse  1711 LQF---------------ISGVSPTTYWLTNFLWDIMNYAVSAGLVVGIFIGFQKKAYTSPDNLP 1760

  Fly   734 SMRSILQ-RGWGIDNPVVY-------------------NGFISISSWVLVFLVLTIL-----LLK 773
            ::.|:|. .||.: .|::|                   |.||.|:|..:.| ||.:.     ||:
Mouse  1761 ALVSLLMLYGWAV-IPMMYPASFLFEVPSTAYVALSCANLFIGINSSAITF-VLELFENNRTLLR 1823

  Fly   774 F 774
            |
Mouse  1824 F 1824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	72/226 (32%)
		CcmA	54..321	CDD:224054	78/340 (23%)
		ABC2_membrane_3	394..770	CDD:289468	83/495 (17%)
		ABC2_membrane	<581..738	CDD:279410	30/197 (15%)
Abca4	NP_031404.1	rim_protein	1..2271	CDD:130324	188/976 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..910
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1344		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2266..2310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900