DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and Abca1

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_006537617.1	Gene:	Abca1 / 11303	MGIID:	99607	Length:	2263	Species:	Mus musculus

Alignment Length:	337	Identity:	86/337 - (25%)
Similarity:	152/337 - (45%)	Gaps:	73/337 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGR 114
            ::...|:|...:.|.|  |.:.:.:|.|..:||||.:|.||:|....:.|...:..|:.::
Mouse  1916 IKELTKIYRRKRKPAV--DRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFL---- 1974

  Fly   115 PGSRGSGVPG-----PRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLP 174
              ::.|.:..     ..:||.||..|:....|.||.:.:|.::..:.:.::....|:.::.|.|.
Mouse  1975 --NKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLV 2037

  Fly   175 N-ASKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVII 238
            . ..|:..|.|||.:|::|.|:||:..|.::.|||||.|:||..|:.:|:..:.|.|.|. :|::
Mouse  2038 KYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGR-SVVL 2101

  Fly   239 TTHYIDEC-------------------AQAHM---------------------------IGLLRG 257
            |:|.::||                   :..|:                           .||...
Mouse  2102 TSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFP 2166

  Fly   258 GKMLAEESPDYLRQQY--NADSLEDVFLKLSVLQNMGKR---RRSSIAQEIVEQVTVPAISNPAL 317
            |.:|.|:..:.|:.|.  :..||..:|   |:|....||   ...|::|..::||.|    |.|.
Mouse  2167 GSVLKEKHRNMLQYQLPSSLSSLARIF---SILSQSKKRLHIEDYSVSQTTLDQVFV----NFAK 2224

  Fly   318 DMSDEQHAAEIS 329
            |.||:.|..::|
Mouse  2225 DQSDDDHLKDLS 2236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	65/271 (24%)
		CcmA	54..321	CDD:224054	82/323 (25%)
		ABC2_membrane_3	394..770	CDD:289468
		ABC2_membrane	<581..738	CDD:279410
Abca1	XP_006537617.1	rim_protein	6..2238	CDD:130324	86/337 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900