DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and ABCA8

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001275914.1	Gene:	ABCA8 / 10351	HGNCID:	38	Length:	1621	Species:	Homo sapiens

Alignment Length:	371	Identity:	93/371 - (25%)
Similarity:	158/371 - (42%)	Gaps:	77/371 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TANSDLDLAARRRLFISQPSTLATRRQQAVCVRR--AHKMYG--SSKNPNVVLDGLNMTVPKGSI 79
            |||     |.....|..:|..:|:      |:|:  |.|..|  |.:...:....::..|.||.:
Human  1265 TAN-----ALNSTNFDEKPVIIAS------CLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEV 1318

  Fly    80 YGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRIGYMPQEIALYGEFTMRE 144
            .||||.:|.||:|.:..|.|..:..:|::.:.|.     |.|.....:||.|||.||:...|:|:
Human  1319 LGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGS-----GGGDALEFLGYCPQENALWPNLTVRQ 1378

  Fly   145 TLIYFGIISAMSKGDIEDRTEFLLKLLNLPNASKF-VKNLSGGQQRRVSLAVALLHEPELLILDE 208
            .|..:..:..:.|||.|.....|:..|.|.:..|. ||.||.|.:|::...:::|..|.:::|||
Human  1379 HLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDE 1443

  Fly   209 PTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDEC-AQAHMIGLLRGGKMLAEESPDYLRQQ 272
            |:.|:||..:|.:|..:....:|.....::||||:.|. |....:.::..|::....|..:|:.:
Human  1444 PSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSK 1508

  Fly   273 YNADSL-----------------------------------------EDV------FLKLSVLQN 290
            :..|.|                                         |||      |.||..::.
Human  1509 FGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQ 1573

  Fly   291 MGKRRRSSIAQEIVEQVTVPAISNPALDMSDEQHAAEISGEFGDNI 336
            .......|::|..:|||        .|::|.||...:...:|..::
Human  1574 SFDLEEYSLSQSTLEQV--------FLELSKEQELGDFEEDFDPSV 1611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	67/227 (30%)
		CcmA	54..321	CDD:224054	79/317 (25%)
		ABC2_membrane_3	394..770	CDD:289468
		ABC2_membrane	<581..738	CDD:279410
ABCA8	NP_001275914.1	rim_protein	<235..>790	CDD:130324
		ABC_subfamily_A	480..703	CDD:213230
		rim_protein	<1033..1598	CDD:130324	90/356 (25%)
		ABC_subfamily_A	1285..1506	CDD:213230	66/225 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900