Protein Alignment CG33970 and ABCA7

DIOPT Version :9

• Sequence 1: NP_001034071.1
• Gene: CG33970 / 43186
• FlyBaseID: FBgn0053970
• Length: 777
• Species: Drosophila melanogaster
• Sequence 2: XP_024307083.1
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2151
• Species: Homo sapiens
• Alignment Length: 994
• Identity: 199/994 - (20%)
• Similarity: 337/994 - (33%)
• Gaps: 339/994 - (34%)

  Fly     9 PPTAPAATATTANSDLDLAARRRLFISQPSTLATRRQQAVCVRRAHKMYGSSKNPNVVLDGLNMT 73
            ||.:||...|..:..:       |....|..|:    ..|.||...|.:..|..|  .|.||::.
Human   779 PPKSPAPCPTPLDPKV-------LVEEAPPGLS----PGVSVRSLEKRFPGSPQP--ALRGLSLD 830

  Fly    74 VPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRIGYMPQEIALYG 138
            ..:|.|...||.:|.||||.||.:.|....:.|..::||....|..:.: .|.:|..||...|:.
Human   831 FYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAI-RPHLGVCPQYNVLFD 894

  Fly   139 EFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNL-PNASKFVKNLSGGQQRRVSLAVALLHEPE 202
            ..|:.|.:.::|.:..:|...:....:.||:.:.| ...|...::||||.||::|:|:|.:...:
Human   895 MLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQ 959

  Fly   203 LLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDECAQAHMIG----LLRGGKMLAE 263
            ::||||||.||||..|:.||:.|:...:.  .|:|::||::||   |.::|    ::.||::...
Human   960 VVILDEPTAGVDPASRRGIWELLLKYREG--RTLILSTHHLDE---AELLGDRVAVVAGGRLCCC 1019

  Fly   264 ESPDYLRQQYNA---------------DSLEDVFLK-----------------------LSVLQN 290
            .||.:||:...:               :...|..::                       |:::|:
Human  1020 GSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQH 1084

  Fly   291 M--GKRRRSSIAQEIV---------------------------------------EQVTVPAISN 314
            .  |.|....:..|:|                                       |::.:..:..
Human  1085 WVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEE 1149

  Fly   315 PALDMSDEQHAAEISGEFGDNISMSSAARD-------PISTTA-----PA--APPLP----PPQE 361
            .|.|...|      .|..|.::....|..|       |...||     ||  ||...    |...
Human  1150 CAADTDME------DGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAV 1208

  Fly   362 IPTSFWYNLHVMQSHHLHALIWKNFLWMMRN-------VGVMLFIVGLPVV-------------- 405
            .....|    .:....|.||:.|.||...|:       :.:....|||.:|
Human  1209 GRVQGW----ALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPAL 1269

  Fly   406 ---------QILLFCYAIGHDPTGLKLAVA---------------NHEMSGEMIMEQF------- 439
                     |:..|......||...:|..|               :|..|...:..:.
Human  1270 RLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASG 1334

  Fly   440 ------------------------CPVH----------TGCNQTM--LSCRYL-DMLVKNKSMVV 467
                                    ||..          ||..:.:  |:.|.| |.|||....:|
Human  1335 NWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLV 1399

  Fly   468 QYVTDDEMAYEEVRKG----------------------RAWAALVIQPNYTASLMERVEDGRYAE 510
            :.....:....|||.|                      ..||.|...|   ...::||.....|.
Human  1400 RQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLP---GGALDRVLKNLTAW 1461

  Fly   511 DGTIESSDLAVRMDWSNQQISQLLYRDLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQHPVYGYRN 575
            ..::::.| ::::.::|:....::      .|.|...:.:....:.|.    |....|.:....:
Human  1462 AHSLDAQD-SLKIWFNNKGWHSMV------AFVNRASNAILRAHLPPG----PARHAHSITTLNH 1515

  Fly   576 P-NFTDFAAPGVILTIIFFLAVAVTSGAMLIDRNEGMLERCLVAGITGPEILLSQVVTQFTVMLS 639
            | |.|               ...::.||::....:.::..|:|       ..:|.|...||::|.
Human  1516 PLNLT---------------KEQLSEGALMASSVDVLVSICVV-------FAMSFVPASFTLVLI 1558

  Fly   640 QTTFVLIVSFYFFELTLVGNI-----WL----------VVALCILNGLCGMSFGFVISCAVDTER 689
            :.......     .|.|:|.:     ||          :|..||: .|..::|           :
Human  1559 EERVTRAK-----HLQLMGGLSPTLYWLGNFLWDMCNYLVPACIV-VLIFLAF-----------Q 1606

  Fly   690 TATYVAMGSFLPIVMLCGII--WPIEG-MFPLLQFF----TAFLPLTKPTESMRSILQRGWGIDN 747
            ...|||..: ||.::|..::  |.|.. |:|...||    ||::.||
Human  1607 QRAYVAPAN-LPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLT------------------ 1652

  Fly   748 PVVYNGFISISSWVLVFLV 766
              ..|.||.|:..:..|::
Human  1653 --CINLFIGINGSMATFVL 1669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	73/226 (32%)
		CcmA	54..321	CDD:224054	82/350 (23%)
		ABC2_membrane_3	394..770	CDD:289468	85/500 (17%)
		ABC2_membrane	<581..738	CDD:279410	35/178 (20%)
ABCA7	XP_024307083.1	rim_protein	1..2114	CDD:130324	199/994 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810