DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6036 and PPM1B

DIOPT Version :9

Sequence 1:	NP_651472.2	Gene:	CG6036 / 43185	FlyBaseID:	FBgn0039421	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_016859884.1	Gene:	PPM1B / 5495	HGNCID:	9276	Length:	487	Species:	Homo sapiens

Alignment Length:	380	Identity:	189/380 - (49%)
Similarity:	251/380 - (66%)	Gaps:	25/380 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MGGFLEKPETEKQAQEGHGNGLRYCVSSMQGWRLEMEDSHSAACRLKDPFATWSYFAVFDGHAGS 69
            ||.||:||:|||....|.||||||.:|||||||:||||:|:|...:......||:|||:||||||
Human     1 MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGS 65

  Fly    70 QISLHCAEHLMSTILESESF------------SKHKYEAGIREGFLQLDEDMRKLYHDQQG---- 118
            :::.:|:.||:..|..:|.|            |....:.|||.|||::||.||.....:.|
Human    66 RVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRS 130

  Fly   119 GSTAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVMIKRINGT 183
            ||||:.|.:||..||.:||||||||:.|||....||.||||.:|:|:||||||||||||:|:||:
Human   131 GSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGS 195

  Fly   184 LAVSRAFGDYDFKNDGSKSPVDQMVSPEPDIIVCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRS 248
            ||||||.||||:|....|.|.:|:|||||::....|:|.||||::|||||||||::.|:||:::|
Human   196 LAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKS 260

  Fly   249 RLLVTYDLPMIVNSVLDICLHKGSRDNMTLLLLLLPGAPKVDMDAVKAERSLDQ--------TIV 305
            ||.|:.||..:.|.|:|.||||||||||:::|:....||||..:|||.:..||:        |..
Human   261 RLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEGTFF 325

  Fly   306 QITKEVIEKHEIHDFETLIRLMKRM-AINIPNLPPGGGLYAKYYIIEQAFHEKFP 359
            :...|::||........|..:|:.: |.|||||||||||..|..:||..:....|
Human   326 KKPTEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNP 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6036	NP_651472.2	PP2Cc	27..277	CDD:238083	142/265 (54%)
CG6036	NP_651472.2	PP2C_C	284..352	CDD:285117	29/76 (38%)
PPM1B	XP_016859884.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11121
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53745
OrthoDB	1	1.010	-	-		D262211at33208
OrthoFinder	1	1.000	-	-		FOG0000692
OrthoInspector	1	1.000	-	-		mtm8647
orthoMCL	1	0.900	-	-		OOG6_100270
Panther	1	1.100	-	-	O	PTHR47992
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X444
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.790