DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nil and Ppm1d

DIOPT Version :10

Sequence 1:NP_651472.2 Gene:Nil / 43185 FlyBaseID:FBgn0039421 Length:371 Species:Drosophila melanogaster
Sequence 2:NP_058606.3 Gene:Ppm1d / 53892 MGIID:1858214 Length:598 Species:Mus musculus


Alignment Length:388 Identity:106/388 - (27%)
Similarity:162/388 - (41%) Gaps:93/388 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 CRLKDPFATWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKH---KYEAGIREGFLQLDEDM 109
            ||.:...|   :|||.|||.|.:.:....|||...|.:.:.|:..   |..|.||:|||.....|
Mouse    85 CRRRSSVA---FFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAM 146

  Fly   110 RKLYHD---------QQGGSTAICVFVSPDKIYLVNCGDSRAVISRNG-------AAVISTIDHK 158
            .|...:         ...|:||..|.:...|:|:.:.|||..|:....       .||..|.|||
Mouse   147 WKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHK 211

  Fly   159 PFSPKEQERIQNAGGSVMIK-----------RINGT--------------LAVSRAFGD---YDF 195
            |..|||:|||:..|||||.|           |:..:              |||:||.||   |||
Mouse   212 PELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVIDQIPFLAVARALGDLWSYDF 276

  Fly   196 KNDGSKSPVDQMVSPEPDIIV--CNRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTYDL-- 256
            .:.      ..:||||||..|  .:..:| ::|::..||:|:::...:.....:.:....|.:  
Mouse   277 FSG------KFVVSPEPDTSVHTLDPRKH-KYIILGSDGLWNMVPPQDAISMCQDQEEKKYLMGE 334

  Fly   257 ------PMIVNSVLDICLHKGSR-DNMTLLLLLLPGAPKVDMDAVKAERSLDQTIVQITKEVIEK 314
                  .|:||..|.....:..| ||.:.:::.:  :|:||........  |:..:.:|    :.
Mouse   335 QGQSCAKMLVNRALGRWRQRMLRADNTSAIVICI--SPEVDNQGNFTNE--DELFLNLT----DS 391

  Fly   315 HEIHDFETLIRLMKRMAINIPNLPP--------GGGLYAKYYI----IEQAFHEKFPDTPAEI 365
            ...:..||.:     |..:..:.||        ...|.:|.:|    ...||.|||.:.||||
Mouse   392 PTYNSQETCV-----MTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSNAFSEKFLEVPAEI 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NilNP_651472.2 PP2Cc 27..277 CDD:238083 84/286 (29%)
PP2C_C 284..355 CDD:429684 14/82 (17%)
Ppm1dNP_058606.3 Interaction with CHEK1. /evidence=ECO:0000250 1..94 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..74
PP2C 78..361 CDD:395385 83/285 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..419 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..584
Blue background indicates that the domain is not in the aligned region.

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