Protein Alignment Nil and PPM1L

DIOPT Version :10

• Sequence 1: NP_651472.2
• Gene: Nil / 43185
• FlyBaseID: FBgn0039421
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_640338.2
• Gene: PPM1L / 151742
• HGNCID: 16381
• Length: 360
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 91/312 - (29%)
• Similarity: 155/312 - (49%)
• Gaps: 49/312 - (15%)

  Fly     4 KMGGF--LEKPETEKQAQEGHGNGLRYCVSSMQGWRLEMEDSHSAACRLKD---PFATWSYFAVF 63
            ::||.  ||...::....:.|    ...|.|:||.|..|||.......|.:   |    |.|.:|
Human    71 RLGGLDVLEAEFSKTWEFKNH----NVAVYSIQGRRDHMEDRFEVLTDLANKTHP----SIFGIF 127

  Fly    64 DGHAGSQISLHCAEHLMSTILES-----ESFSKHK------YEAGIREGFLQLDEDMRK---LYH 114
            |||.|..    .||::.|.:.|:     :.:.|.|      |:..:.:..|.:|.:|.:   :.:
Human   128 DGHGGET----AAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVSY 188

  Fly   115 DQQGGSTAICVFVSPDKIYLVNCGDSRAVI-SRNGAAVISTIDHKPFSPKEQERIQNAGGSVMIK 178
            | :.|:|.:...:|...:.:.|.||||.|: .::|.|:..:.||||:..||::||:.|||.:...
Human   189 D-EAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN 252

  Fly   179 ---RINGTLAVSRAFGDYDFKNDGSKSPVDQMVSPEPDIIVCNRSE-HDEFIVVACDGIWDVMTS 239
               |:.|.||:||:.|||..||       ..:|.|:|||:..:..: ..||:::|.||:||..::
Human   253 GSWRVQGILAMSRSLGDYPLKN-------LNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSN 310

  Fly   240 SEVCEFIRSRLLVTYDLPMI-VNSVLDICLHKGSRDNMTLLLLLLPGAPKVD 290
            .|...||:.||    |.|.. ..|::....::|..||:|::::....:.|.:
Human   311 EEAVRFIKERL----DEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTE 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nil	NP_651472.2	PP2Cc	27..277	CDD:238083	84/272 (31%)
		PP2C_C	284..355	CDD:429684	1/7 (14%)
PPM1L	NP_640338.2	PP2Cc	93..351	CDD:238083	85/277 (31%)