DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6036 and PPM1M

DIOPT Version :9

Sequence 1:	NP_651472.2	Gene:	CG6036 / 43185	FlyBaseID:	FBgn0039421	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_653242.3	Gene:	PPM1M / 132160	HGNCID:	26506	Length:	459	Species:	Homo sapiens

Alignment Length:	372	Identity:	87/372 - (23%)
Similarity:	142/372 - (38%)	Gaps:	123/372 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EKPE-TEKQAQEGHGNGLRYCVSSMQGWRLEM--EDSHSAACRLKDPFATWSYFAVFDGHAG--- 68
            ||.| .|.||..|     :.|:.     |.|.  |:.....|  .:.|.|..|:|:||||.|
Human    80 EKSEFNEDQAACG-----KLCIR-----RCEFGAEEEWLTLC--PEEFLTGHYWALFDGHGGPAA 132

  Fly    69 ---SQISLH-CAEHLMSTILES----------------ESFSKHKYEAGIR----------EGFL 103
               :..:|| |....:..::|.                .|..:...|.|||          ..|.
Human   133 AILAANTLHSCLRRQLEAVVEGLVATQPPMHLNGRCICPSDPQFVEEKGIRAEDLVIGALESAFQ 197

  Fly   104 QLDEDM-RKL-YHDQQGGSTAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKP----FSP 162
            :.||.: |:| ...|.||.||:.......|:|:.|.|||||::.|..       :.:|    |:|
Human   198 ECDEVIGRELEASGQMGGCTALVAVSLQGKLYMANAGDSRAILVRRD-------EIRPLSFEFTP 255

  Fly   163 K-EQERIQ--------------------------NAGGSVMIK---------------------- 178
            : |::|||                          :.|..|:.:
Human   256 ETERQRIQQLAFVYPELLAGEFTRLEFPRRLKGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLI 320

  Fly   179 -------RINGTLAVSRAFGDYDFKNDGSKSPVDQMVSPEPDIIVCN----RSEHDEFIVVACDG 232
                   |:.|||||||..||:..:...:...:...:...|.:.|.:    ..:.|:.:|:|.||
Human   321 HGQGRQARLLGTLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDG 385

  Fly   233 IWDVMTSSEVCEFIRSRLLVTYDLPMIVNSVLDICLH--KGSRDNMT 277
            :|||:::.:|...:||.|....:.|...:.:..:.:|  :|..|::|
Human   386 LWDVLSNEQVAWLVRSFLPGNQEDPHRFSKLAQMLIHSTQGKEDSLT 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6036	NP_651472.2	PP2Cc	27..277	CDD:238083	79/352 (22%)
CG6036	NP_651472.2	PP2C_C	284..352	CDD:285117
PPM1M	NP_653242.3	PP2Cc	118..449	CDD:238083	73/322 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840