DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6154 and DPEP1

DIOPT Version :9

Sequence 1:	NP_651471.2	Gene:	CG6154 / 43184	FlyBaseID:	FBgn0039420	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001121613.1	Gene:	DPEP1 / 1800	HGNCID:	3002	Length:	411	Species:	Homo sapiens

Alignment Length:	377	Identity:	186/377 - (49%)
Similarity:	249/377 - (66%)	Gaps:	15/377 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DFRMQRVRNVLKEVPLIDGHNDLPWNIRKFLKNQLKDFHFGGDLRELAPWSSSAWSHTDLRRLKE 116
            ||.......::::.|:|||||||||.:.....|:|:|        |.|..::.|.:||::.:|:.
Human    17 DFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQD--------ERANLTTLAGTHTNIPKLRA 73

  Fly   117 GMVSAQFWSAYAPCSSQHLDAVQLTLEQIDLIRRLVQLYPHHMALVTTASGIEQTHRTGKIASLI 181
            |.|..||||.|.||.:|:.|||:.||||:|::.|:.::||.....||:::||.|..|.||:||||
Human    74 GFVGGQFWSVYTPCDTQNKDAVRRTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLI 138

  Fly   182 GVEGGHAIGTSLSVLRMFYQLGARYLTLTHTCNTPWADCCKVDEPGKYPHIGGLSQFGKLVVKEM 246
            ||||||:|.:||.|||..||||.|||||||:|||||||...||.....|...|||.||:.||||:
Human   139 GVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWADNWLVDTGDSEPQSQGLSPFGQRVVKEL 203

  Fly   247 NRLGMIVDLSHVSVPTMLDALAASRAPLIFSHSSAHAICNSSRNVPDHVLQRIAINGGLVMVAFY 311
            ||||:::||:||||.||...|..||||:|||||||:::|.|.|||||.||:.:.....||||.||
Human   204 NRLGVLIDLAHVSVATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLVKQTDSLVMVNFY 268

  Fly   312 PHFVSCSGQATLHDVVAHINHIREVAGIDHVGIGAGYDGVNLVPKGLEDVSKYPHLFAALLESDK 376
            .:::||:.:|.|..|..|::||:||||...||.|..:|||..||:|||||||||.|.|.||..:
Human   269 NNYISCTNKANLSQVADHLDHIKEVAGARAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRN- 332

  Fly   377 WSEEDIAKLAGRNLIRVFKEVEAVRDQMELLRVAPIDQSIPAEDIMGRSYCR 428
            |:|.::......||:|||:.||    |...|..||.::.||.:.:.|.  ||
Human   333 WTEAEVKGALADNLLRVFEAVE----QASNLTQAPEEEPIPLDQLGGS--CR 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6154	NP_651471.2	Peptidase_M19	61..396	CDD:395996	173/334 (52%)
DPEP1	NP_001121613.1	Peptidase_M19	26..352	CDD:395996	173/334 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155232
Domainoid	1	1.000	347	1.000	Domainoid score	I1037
eggNOG	1	0.900	-	-		E1_COG2355
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80192
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2197
Isobase	1	0.950	-	0	Normalized mean entropy	S6062
OMA	1	1.010	-	-		QHG53057
OrthoDB	1	1.010	-	-		D1272387at2759
OrthoFinder	1	1.000	-	-		FOG0001225
OrthoInspector	1	1.000	-	-		otm42184
orthoMCL	1	0.900	-	-		OOG6_102004
Panther	1	1.100	-	-	O	PTHR10443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R335
SonicParanoid	1	1.000	-	-		X677
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750