Protein Alignment CG12290 and TyrRII

DIOPT Version :10

• Sequence 1: NP_651470.1
• Gene: CG12290 / 43182
• FlyBaseID: FBgn0039419
• Length: 798
• Species: Drosophila melanogaster
• Sequence 2: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 696
• Identity: 130/696 - (18%)
• Similarity: 214/696 - (30%)
• Gaps: 278/696 - (39%)

  Fly     6 LILALLLVSFLINLLALCAFWITPGLRTTANRFTINLLAIN-LIGCCILAPTLFLGLPGKSAEAS 69
            :.|.::||:.:.|.|.:.|...|..|||..|.|.:||...: |:|.|::.|::.|.:.|
  Fly    80 VFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITG------ 138

  Fly    70 TSNAETLEFFSKPGNHQVILRRNGQLVEQDGVVVRRNISENGDTVETFFKCNATYCRELTIDERG 134
                 |..|
  Fly   139 -----TWRF-------------------------------------------------------- 142

  Fly   135 DGGFVITETETHEENLSAFESLPTEAPILPPVQLRCW-SIDMTAALGALAVLLVVG-DTWCAVTD 197
              |:::.:                           .| |:|:....|::..|..:. |.:.|||.
  Fly   143 --GWILCD---------------------------IWISLDILLCSGSILSLCAISLDRYLAVTQ 178

  Fly   198 PLRY-HSRISGVKTWIFIALTWVVGILFGA---LSAFRVLDFEA---DALFSRQRRLAVTYFNIS 255
            ||.| ..|.|.....:.|.:.|:..:....   |..:.|...:|   |..:::.:    .|...|
  Fly   179 PLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNK----GYVVFS 239

  Fly   256 STNSIFGVVYASVYFIVIILLPFGFVCGMYWRIFSEARGNGLRMRQNGSSPLLQSALN-LTAGQQ 319
            :..|.|..:...:|..|.|    |:|.            ...|.|      :::.|.: .||...
  Fly   240 AMGSFFIPLTVMLYVYVKI----GYVL------------TSRRQR------IVRDAYSERTADYD 282

  Fly   320 AAQANQFSNSLCVHRH-------------------------SISSASSHGGNSSLGLGGLQMQID 359
            ....|..|.|  .|.|                         :.::|::.|..||:
  Fly   283 VDGDNFISES--EHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSV---------- 335

  Fly   360 QRQQPRSSPSCLRRDSAAKVLLPTISDDGGSDAESGAGVQLMPVQEHSLSDRNQNIMLTLQTASG 424
                  ....|.:..||.          |.:.|.:|||     |.:.:|:.::|.....|...|
  Fly   336 ------KCSKCSKCSSAT----------GTAGAGAGAG-----VVDKTLTFKHQPTFYELVEVS- 378

  Fly   425 EIKRNYSARQLPLLGTSSQDLRETNRLQGIRQVHSSPNLHKY--TELRQDSLSEECGSPHLLGHA 487
                    |...|:..|:...:     .|...:||:|:...|  ||.   |.|:.|...::..:.
  Fly   379 --------RLSSLIHCSAISCK-----YGGPCMHSTPSGMHYVGTEA---SFSDTCLGGNVSNNT 427

  Fly   488 ---------------------QRQQQQQLHLQHQQQQHHHHQQHHPHFSSPRHQQHGHALQIPAI 531
                                 |:||||:....|    ||.|..||.......|..|.|.:.:
  Fly   428 TTTTTNTVALETNEKLEAEAKQKQQQQRSSFDH----HHPHAHHHGSHGQQSHHNHHHRMPM--- 485

  Fly   532 HASPKALSYMSSLRHRLSNASSLFKYREESRAARISILVVVMFVVSYLPFGLLVLL------QSR 590
                           |:|..      :.:|:.|:...:|:...:..:|||.:..||      .:.
  Fly   486 ---------------RVSTT------KRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAV 529

  Fly   591 LSAANFG----GSSQLAIFMILLANLSSPFIFAYRNKRVRRGVKRL 632
            |....||    |....||         :|||:|:.|...|....||
  Fly   530 LEDLMFGFTWIGWVNCAI---------NPFIYAFYNPDFRTAFWRL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12290	NP_651470.1	7tm_classA_rhodopsin-like	<192..>312	CDD:410626	25/126 (20%)
		TM helix 4	209..228	CDD:410626	2/21 (10%)
		TM helix 5	262..287	CDD:410626	5/24 (21%)
		7tm_classA_rhodopsin-like	<544..622	CDD:410626	20/87 (23%)
		TM helix 6	558..588	CDD:410626	8/35 (23%)
		TM helix 7	600..622	CDD:410626	6/21 (29%)
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	54/311 (17%)
		TM helix 1	78..101	CDD:410628	6/20 (30%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	5/48 (10%)
		TM helix 4	194..210	CDD:410628	2/15 (13%)
		TM helix 5	233..256	CDD:410628	5/26 (19%)
		7tm_GPCRs	<491..563	CDD:475119	20/80 (25%)
		TM helix 6	497..519	CDD:320098	5/21 (24%)
		TM helix 7	531..556	CDD:320098	9/33 (27%)