Protein Alignment CG12290 and dop-6

DIOPT Version :10

• Sequence 1: NP_651470.1
• Gene: CG12290 / 43182
• FlyBaseID: FBgn0039419
• Length: 798
• Species: Drosophila melanogaster
• Sequence 2: NP_001359889.1
• Gene: dop-6 / 180706
• WormBaseID: WBGene00016037
• Length: 692
• Species: Caenorhabditis elegans
• Alignment Length: 737
• Identity: 132/737 - (17%)
• Similarity: 245/737 - (33%)
• Gaps: 245/737 - (33%)

  Fly     6 LILALL-LVSFLINLLALCAFWITPGLRTTANRFTINLLAINLI-GCCILAPTLFLGLPGKSAEA 68
            |:|::: ||..|.||:.:.|.|.|..|:|..|...::|...:|| |..::..:::|.
 Worm    27 LVLSIVPLVCILGNLMVVAAVWTTKSLQTPTNHLLVSLAMADLIVGAFVMPFSIYLS-------- 83

  Fly    69 STSNAETLEFFSKPGNHQVILRRNGQLVEQDGVVVRRNISENGDTVETFFKCNATYCRELTIDER 133
                               :.|.:..|                    ..|.| ..||
 Worm    84 -------------------VNRLHWHL--------------------PLFVC-YFYC-------- 100

  Fly   134 GDGGFVITETETHEENLSAFESLPTEAPILPPVQLRCWSIDMTAALGALAVLLVVG-DTWCAVTD 197
                                                  .:|:.|:..::..|:::. |...|.|.
 Worm   101 --------------------------------------VLDVAASTSSIIHLVLISIDRLVAATK 127

  Fly   198 PLRYHSRISGVKTWIFIALTWVVGILFGALSAFRVLDFEADALFSRQRRLAVTYFNISSTN-SIF 261
            |..|.:.....:.::.||:||:..|   |||......|..          ..:||.:...: .|:
 Worm   128 PAEYKTVKHRKRVYLAIAITWIFSI---ALSLPLGTGFNT----------RTSYFLVIEHHCGIY 179

  Fly   262 GVVY---ASVYFI----VIILLPFGFVCGMYWRIFSEARGNGLRMRQNGS--------SPLLQSA 311
            ..:|   :|::..    :|::..:|::   ::.:....|...|:....|.        |.:..||
 Worm   180 NPIYMLGSSIFAFYLPCLIMIFTYGYI---FYTLRKRLRAIQLQEMAGGQFLGFGADVSNITTSA 241

  Fly   312 LNLTAGQQAAQANQFSNSLCVHRHSISSASSHGGNSSLGLGGLQMQIDQRQQPRSSPSCLRRDSA 376
            :....|......|..:....:.:....:|:.|..:         :...:|:|.::....:...|:
 Worm   242 IQSVIGIAPKNRNMITWEKPLLKKIEETAAEHASS---------LNDSEREQLQTILEAVHPSSS 297

  Fly   377 AKVLLPTISDDGGSDAESGAGVQLMPVQEHSLSDRNQNIMLTLQTASGEIKRNYSARQLPLLGTS 441
            ......||.:|                     .||..:::|...|...||..:....:||
 Worm   298 GSQENTTIEED---------------------PDRPPSVLLEAVTLKCEIDTSGPILELP----- 336

  Fly   442 SQDLRETNRLQGIRQVHSSPNLHKYTELRQDSLSEECGSPHLLGHAQRQQQQQLHLQHQQQQHHH 506
                |.|                 ||:......|:...|     .:.|.:.:.:.....:::.|.
 Worm   337 ----RPT-----------------YTKNMSRRFSDAVNS-----ISSRGRMKSVSFGTSRKRRHS 375

  Fly   507 HQ-QHHPHFSSPRHQQHGHALQIPAIH-ASPKALSYMSS--LRHRLSNASSLFKY---------- 557
            || |.:....:....:..|:|:.|.:. ...:.||.|.|  .|...|:.|:::.|
 Worm   376 HQPQGNREVVTSEESKKLHSLKPPLVEKRKMRRLSEMISDWERPSRSSISNMYLYARRESVYIAR 440

  Fly   558 -------------------------REESRAARISILVVVMFVVSYLPFGLLVLLQSRLSAANFG 597
                                     |.|:||.::...|:|:|:|.:|||..|.:::......|.
 Worm   441 KKLAGLKDWALDLLAKLKSKQGMAIRRETRATKLVATVMVVFLVCWLPFFTLNMIKIYKLIFNV- 504

  Fly   598 GSSQLAI---FMILLANLSSP---FIFAYRNKRVRRGVKRLFGLDSSSGLQRNCSSSV-KTNGTA 655
            .|:.|.|   :...|..|:|.   ||::..|.:.|...:||.|...||..||..|..: ..:.:.
 Worm   505 WSADLEIWFHWFTALGYLNSSLNFFIYSTINPKFRHSFRRLLGFRRSSRRQREKSWMLPPRDSSR 569

  Fly   656 GPAASG--------AQLQRNSS 669
            |||..|        :.|::.||
 Worm   570 GPAKCGCGFHKIVKSPLRKTSS 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12290	NP_651470.1	7tm_classA_rhodopsin-like	<192..>312	CDD:410626	25/135 (19%)
		TM helix 4	209..228	CDD:410626	6/18 (33%)
		TM helix 5	262..287	CDD:410626	4/31 (13%)
		7tm_classA_rhodopsin-like	<544..622	CDD:410626	25/118 (21%)
		TM helix 6	558..588	CDD:410626	12/29 (41%)
		TM helix 7	600..622	CDD:410626	7/27 (26%)
dop-6	NP_001359889.1	7tmA_amine_R-like	24..>217	CDD:320098	49/299 (16%)
		TM helix 1	24..50	CDD:320098	9/22 (41%)
		TM helix 2	57..84	CDD:320098	6/53 (11%)
		TM helix 3	96..126	CDD:320098	8/76 (11%)
		TM helix 4	138..158	CDD:320098	8/22 (36%)
		TM helix 5	180..210	CDD:320098	4/32 (13%)
		7tm_GPCRs	<464..542	CDD:475119	23/78 (29%)
		TM helix 6	472..494	CDD:410628	8/21 (38%)
		TM helix 7	513..535	CDD:410628	5/21 (24%)