DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34129 and PLAU

DIOPT Version :9

Sequence 1:	NP_001036760.1	Gene:	CG34129 / 43181	FlyBaseID:	FBgn0083965	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens

Alignment Length:	293	Identity:	70/293 - (23%)
Similarity:	120/293 - (40%)	Gaps:	43/293 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLVSCLLWTCLPQSQGTVYPRDILL----KT--PKFRRVWGGVQS-NTGPNFGGWLLRILNGDGN 65
            |:..|::..|....:.:..|.::..    ||  |:|:.:.|...: ...|.|.....|...|...
Human   142 LVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVT 206

  Fly    66 FACGAAYYAPLLVITSANCIYPYRNSLEGATVEGTAFSECDRENYADIDTIQFP-EKFIYQKLYM 129
            :.||.:..:|..||::.:|...|....:.....|.:     |.|......::|. |..|..|.|.
Human   207 YVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRS-----RLNSNTQGEMKFEVENLILHKDYS 266

  Fly   130 --------DVAVVRLRDPVRGRLTEFIRLCSVKVQPKM--------QMVVFGWGFDNTEVEIPSS 178
                    |:|::::|.. .||..:..|.......|.|        ...:.|:|.:|:...:...
Human   267 ADTLAHHNDIALLKIRSK-EGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPE 330

  Fly   179 DPRNVTVTIISIKECRQ-KFKSPKIASTSICARQPK-NPKQCLYDGGSPLI---YGR-ELCGVVS 237
            ..:...|.:||.:||:| .:...::.:..:||..|: ....|..|.|.||:   .|| .|.|:||
Human   331 QLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVS 395

  Fly   238 FGSHCIDTSRPGMYTNIRRVKRFI----TETEE 266
            :|..|....:||:||   ||..|:    :.|:|
Human   396 WGRGCALKDKPGVYT---RVSHFLPWIRSHTKE 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34129	NP_001036760.1	Tryp_SPc	39..261	CDD:214473	59/245 (24%)
CG34129	NP_001036760.1	Tryp_SPc	55..261	CDD:304450	56/228 (25%)
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056	2/9 (22%)
		Connecting peptide	152..177		4/24 (17%)
		Tryp_SPc	179..422	CDD:238113	60/251 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910