DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34129 and PRSS36

DIOPT Version :9

Sequence 1:	NP_001036760.1	Gene:	CG34129 / 43181	FlyBaseID:	FBgn0083965	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	313	Identity:	69/313 - (22%)
Similarity:	117/313 - (37%)	Gaps:	74/313 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PRDILLKTPK-FRRVWGGVQSNTGPNFGGWLLRILNGDGNFACGAAYYAPLLVITSANCIYPYRN 90
            |.|:....|: ..|:.||  ||..|....|.:.:.:|.|:. ||.:..||..|:::|:| :....
Human    33 PEDLDCGRPEPSARIVGG--SNAQPGTWPWQVSLHHGGGHI-CGGSLIAPSWVLSAAHC-FMTNG 93

  Fly    91 SLEGATVEGTAFSECDRENYAD------IDTIQFPEKFIYQKLYMDVAVVRLRDPVRGRLTEFIR 149
            :||.|...........::...|      :..|..|..:...:|..|:|::||..|
Human    94 TLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASP---------- 148

  Fly   150 LCSVKVQPKMQMVVF----------------GWGFDNTEVEIPSSDP-------RNVTVTIISIK 191
               ..:.|.:..|..                |||      ::..:||       :.|.:.::...
Human   149 ---ASLGPAVWPVCLPRASHRFVHGTACWATGWG------DVQEADPLPLPWVLQEVELRLLGEA 204

  Fly   192 ECRQKFKSP-------KIASTSICARQPKNPKQ-CLYDGGSPLIY---GREL-CGVVSFGSHCID 244
            .|:..:..|       :|....:||..|:..:. |..|.|.||:.   ||.. .|:.|||..|..
Human   205 TCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGR 269

  Fly   245 TSRPGMYTNIRRVKRFITETEESINAGDVFRSTKVVKETKKPPKKTIKPKSKP 297
            .:|||::|.:...:.:|.|.......|..|.:         .|:||.....:|
Human   270 RNRPGVFTAVATYEAWIREQVMGSEPGPAFPT---------QPQKTQSDPQEP 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34129	NP_001036760.1	Tryp_SPc	39..261	CDD:214473	58/262 (22%)
CG34129	NP_001036760.1	Tryp_SPc	55..261	CDD:304450	52/246 (21%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	58/262 (22%)
		Tryp_SPc	47..289	CDD:238113	58/264 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316		6/31 (19%)
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100