DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6073 and hgh1

DIOPT Version :9

Sequence 1:	NP_001247313.1	Gene:	CG6073 / 43180	FlyBaseID:	FBgn0039417	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001007916.1	Gene:	hgh1 / 493297	XenbaseID:	XB-GENE-997807	Length:	359	Species:	Xenopus tropicalis

Alignment Length:	356	Identity:	130/356 - (36%)
Similarity:	196/356 - (55%)	Gaps:	17/356 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELVQFMQPNQRLDLKAVALTHVLGLTGSSEGKSAILSLDEMLMAIFGLTFDANQTVAKDAVLSLI 70
            ||:.|::|..|.|::|.||.::||::||.||:.::.:...:|.|:..|:.:.:..||:||...|:
Frog     8 ELLSFLKPETRADVRAQALEYILGVSGSPEGRQSLCAEPRLLCALLDLSTEQSPHVAQDAHHVLV 72

  Fly    71 NLTSEEEAAIKVFQLAKQLQPPFAIVEVAAKEITNEQSDLADPWSMVLSNLTRVESLVHEILDTL 135
            ||||:..|...:......|.|..      ...:.:.....||.....|.||:|.|......|.:|
Frog    73 NLTSDCAAHRALLAHVPTLLPSM------LSRLRDPGCPFADSICTALCNLSREEETCQSFLRSL 131

  Fly   136 ERDDHTLPRLAKAFAQLDYNKKKAKLHYLAPIFCNLTQVSRGRELCCHRKYELLEKLLPFASFEG 200
            .::.  :.:|........|| .:|.|.||.|:.|||||:..||.....|...::::|||:.. .|
Frog   132 TQEG--MCQLLDMLCAPKYN-PRASLDYLGPLLCNLTQLPEGRHFILDRNRCVVQRLLPYLQ-SG 192

  Fly   201 SVVRRGGTIGILKNVCFDTVYHDVILNEQSSILVAILQPLCGPEEFSDEDNELLPIELQYLPESK 265
            |.|||||.:|.|:|.||....|..:|.:...:|..:|.||.|.|||::|:.|.||.:||||.|.|
Frog   193 STVRRGGIVGTLRNCCFSHRDHAWLLGDDVDLLPFLLLPLAGGEEFTEEEMETLPPDLQYLAEDK 257

  Fly   266 TREEDPDLRKMLLECLLQLCSTRRSREILRSRGVYEILREYHKWEAKVGKDSDCL-LACENVVDI 329
            .||.|||:||||:|.:|.||:|...|.:::.||.|.::||.|.||.:     .|: .|||.::.:
Frog   258 QREADPDIRKMLIETVLLLCATADGRRLVKQRGTYLVMRELHSWERE-----PCVKRACEKLIQM 317

  Fly   330 LIKKEEEIGLDNYKTEVEVPAEQSEKFVQED 360
            ||.:|.|.||:|. .||.||.:..|...:.|
Frog   318 LIGEEPEAGLENL-LEVTVPPDLEETLSRLD 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6073	NP_001247313.1	DUF383	103..275	CDD:281984	65/171 (38%)
CG6073	NP_001247313.1	DUF384	280..337	CDD:281985	20/57 (35%)
hgh1	NP_001007916.1	DUF383	98..267	CDD:367793	65/172 (38%)
hgh1	NP_001007916.1	DUF384	272..324	CDD:367794	20/56 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48742
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3537
OMA	1	1.010	-	-		QHG54604
OrthoDB	1	1.010	-	-		D1094436at2759
OrthoFinder	1	1.000	-	-		FOG0004316
OrthoInspector	1	1.000	-	-		otm49230
Panther	1	1.100	-	-	LDO	PTHR13387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R426
SonicParanoid	1	1.000	-	-		X3587
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110