DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6073 and Hgh1

DIOPT Version :9

Sequence 1:	NP_001247313.1	Gene:	CG6073 / 43180	FlyBaseID:	FBgn0039417	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001007708.1	Gene:	Hgh1 / 315094	RGDID:	1359226	Length:	393	Species:	Rattus norvegicus

Alignment Length:	359	Identity:	130/359 - (36%)
Similarity:	199/359 - (55%)	Gaps:	16/359 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VKELVQFMQPNQRLDLKAVALTHVLGLTGSSEGKSAILSLDEMLMAIFGLTFDANQTVAKDAVLS 68
            |.||:.|:.|..|.||:|.|..|||.|||...|::.:.....:|.|:..|........::||..:
  Rat    27 VAELLPFLVPGARADLQAAAAQHVLALTGVGSGRTLLAGQTALLRALIDLAVAPIPAPSRDASRA 91

  Fly    69 LINLTSEEEAAIKVFQLAKQLQPPFAIVEVAAKEITNEQSDLADPWSMVLSNLTRVE---SLVHE 130
            |:||.::.:...::  ||...:.|..::..    :.:.|...|:..:.||:||:|..   :::.|
  Rat    92 LVNLAADPDLHWQM--LAADPELPVRLLRC----VLDPQWPWAEELAAVLANLSREPAPCAVLTE 150

  Fly   131 ILDTLERDDHTLPRLAKAFAQLDYNKKKAKLHYLAPIFCNLTQVSRGRELCCHRKYELLEKLLPF 195
            .|...|.:...|.||..|.....|| ..|.||||.|:..||:|.:..|.........::::|||.
  Rat   151 KLVAAEPERLGLERLVSALCMPSYN-ASAPLHYLGPLLSNLSQQAEVRAFLLDPDRCVVQRLLPL 214

  Fly   196 ASFEGSVVRRGGTIGILKNVCFDTVYHDVILNEQSSILVAILQPLCGPEEFSDEDNELLPIELQY 260
            ..:..|.|||||.:|.|:|.||:..:|..:|..|..||..:|.||.||||||:|:.|.||::|||
  Rat   215 TQYTDSSVRRGGVVGTLRNCCFEHRHHKWLLGPQVDILPFLLLPLAGPEEFSEEEMEELPVDLQY 279

  Fly   261 LPESKTREEDPDLRKMLLECLLQLCSTRRSREILRSRGVYEILREYHKWEAKVGKDSDCLLACEN 325
            |...|.||.|.|:||||:|.::.|.:|...|:.:|.:|.|.||||.:.||:    :.|..:|||.
  Rat   280 LSPDKQREPDADIRKMLIEAIMLLTATAPGRKQVRDQGAYLILRELYAWES----EPDVRMACEK 340

  Fly   326 VVDILIKKEEEIGLDNYKTEVEVPAEQSEKFVQE 359
            ::.:||..|.|:|::|. .||:|| |..|:.:||
  Rat   341 LIQVLIGDEPEVGMENL-LEVQVP-EDVERQLQE 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6073	NP_001247313.1	DUF383	103..275	CDD:281984	67/174 (39%)
CG6073	NP_001247313.1	DUF384	280..337	CDD:281985	19/56 (34%)
Hgh1	NP_001007708.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		DUF383	120..294	CDD:281984	67/174 (39%)
		DUF384	299..351	CDD:281985	19/55 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353843
Domainoid	1	1.000	114	1.000	Domainoid score	I5961
eggNOG	1	0.900	-	-		E1_KOG2973
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48742
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3633
OMA	1	1.010	-	-		QHG54604
OrthoDB	1	1.010	-	-		D1094436at2759
OrthoFinder	1	1.000	-	-		FOG0004316
OrthoInspector	1	1.000	-	-		oto98322
orthoMCL	1	0.900	-	-		OOG6_103137
Panther	1	1.100	-	-	LDO	PTHR13387
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3587
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770