DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6073 and SPAC26F1.12c

DIOPT Version :9

Sequence 1:	NP_001247313.1	Gene:	CG6073 / 43180	FlyBaseID:	FBgn0039417	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_594883.1	Gene:	SPAC26F1.12c / 2542675	PomBaseID:	SPAC26F1.12c	Length:	356	Species:	Schizosaccharomyces pombe

Alignment Length:	387	Identity:	117/387 - (30%)
Similarity:	192/387 - (49%)	Gaps:	58/387 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METVKELVQFMQPNQRLDLKAVALTHVLGLTGSSEGKSAILSLD--EMLMAIFGLTFDANQTVAK 63
            |..:.|||.|:. :|...::.:|:.|:|..|..:..:.:|...:  |.:..:..|..|..| :|.
pombe     1 MSELIELVGFLH-DQNPQVRMLAVQHLLPYTARNHPQFSIWFHNDFEPVKDLKALLKDKPQ-IAS 63

  Fly    64 DAVLSLINLTSEEEAAIKVFQLAKQLQPPFAIVEVAAKEITNEQSDLADPWSMVLSNLTRVE--- 125
            .||.:|:|: |:.|...||....:.||..|:||       ||....|||...|:|.||.:.|
pombe    64 QAVTALVNV-SQNEKVRKVLMDDEFLQLIFSIV-------TNPLHGLADLSCMLLCNLAKEEDFA 120

  Fly   126 ------------SLVHEILDTL-----ERDDHTLPRLAKAFAQLDYNKKKAKLHYLAPIFCNLTQ 173
                        ||...|:|.|     :..||.:    ..:|..|         :||.:|.::|:
pombe   121 RILDMQVPLREFSLSKNIIDQLMDLFVKGTDHGI----NEYANFD---------FLANVFADMTR 172

  Fly   174 VSRGRE-LCCHRKYELL---EKLLPFASFEGSVVRRGGTIGILKNVCFDTVYHDVILNEQS-SIL 233
            ..|||: ....::|:.:   .||:.|...: |::||.|...|:||:.||..:..|:::|:. ::|
pombe   173 FERGRKYFTTLQEYDHVIPASKLVVFTEHK-SLLRRTGVAAIIKNISFDIPFQKVLMDEEGINVL 236

  Fly   234 VAILQPLCGPEEFSDEDNELLPIELQYLPESKTREEDPDLRKMLLECLLQLCSTRRSREILRSRG 298
            ..:|.||.||||.|:||.:.:..|||.||:.|.||.|..:.|.|:|.|:.|.:||..||.:|.|.
pombe   237 PYLLLPLAGPEELSEEDMDGMFDELQLLPDDKKREPDHFIMKTLVETLVLLTATREGREHMRRRK 301

  Fly   299 VYEILREYHKWEAKVGKDSDCLLACENVVDILIKKEEEIGLDNYKTEVEVPAEQSEKFVQED 360
            ||.|:||.|   ..| .|.:....|:.:|.:|::.|....|::.:   :.|.::.:..|:.|
pombe   302 VYPIIRELH---LNV-DDEEIREVCDQLVQMLVRDEAPEELEHIQ---DNPPDEDDVIVEVD 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6073	NP_001247313.1	DUF383	103..275	CDD:281984	61/196 (31%)
CG6073	NP_001247313.1	DUF384	280..337	CDD:281985	20/56 (36%)
SPAC26F1.12c	NP_594883.1	DUF383	95..278	CDD:281984	62/203 (31%)
SPAC26F1.12c	NP_594883.1	DUF384	283..336	CDD:281985	20/56 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	77	1.000	Domainoid score	I2429
eggNOG	1	0.900	-	-		E1_KOG2973
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48742
Inparanoid	1	1.050	124	1.000	Inparanoid score	I1467
OMA	1	1.010	-	-		QHG54604
OrthoFinder	1	1.000	-	-		FOG0004316
OrthoInspector	1	1.000	-	-		oto101892
orthoMCL	1	0.900	-	-		OOG6_103137
Panther	1	1.100	-	-	LDO	PTHR13387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R426
SonicParanoid	1	1.000	-	-		X3587
TreeFam	1	0.960	-	-
	14	13.860