DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6142 and CG9522

DIOPT Version :9

Sequence 1:	NP_651466.1	Gene:	CG6142 / 43178	FlyBaseID:	FBgn0039415	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_644677.1	Gene:	CG9522 / 32413	FlyBaseID:	FBgn0030587	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	253/567 - (44%)
Similarity:	357/567 - (62%)	Gaps:	9/567 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 YDFIIVGAGSAGCVMANRLSEISSASVLLLEAGDQETFISDVPLTAALTQMTRYNWGYKAEPTEH 112
            |||||||.|:|||.:|.||||..:.||.|:|||..|..:..|||.||..|.|..||||.:.|..|
  Fly    51 YDFIIVGGGAAGCTLAARLSENPNWSVFLIEAGGVENIVHQVPLLAAHLQSTASNWGYNSTPQRH 115

  Fly   113 ACQGLKGGVCNWPKGRGVGGTSLINFMLYTRGHRRDYDEWAAANNSGWSYDELLPYFRKSERIGI 177
            ||:|:....|..|:|:.:||||.||:|:|.||:|||:|.||||.|.||||||:||||.:||...:
  Fly   116 ACRGMPDNKCALPRGKVLGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSEHAQL 180

  Fly   178 PELYKSPYHGRNGQLDVQYTDYRSQLLKAFLKSGREMGYEITDPNGEHLMGFARSQATIRNGRRC 242
            ..|..||||..:|.|.|:...:|::|..|::::.:|.|:..||.|||..:|.:..|||...|||.
  Fly   181 QGLEHSPYHNHSGPLSVEDVRHRTRLAHAYIRAAQEAGHPRTDYNGESQLGVSYVQATTLKGRRH 245

  Fly   243 STSKAFIQPVVNRK-NLHISMKSWVTRLIIDPITKTATGVEFVKQRQRYVVRARKEVILSAGTIA 306
            |..:|:|:|:.:|: ||||...:.|||::||..||:|.|||...|.:.:.|:||||:|||||...
  Fly   246 SAFRAYIEPIRSRRHNLHILTLARVTRVLIDAATKSAYGVELTHQGRSFKVKARKEIILSAGAFN 310

  Fly   307 SPQLLMLSGIGPAEHLREHNITVMQDLPVGYNLQDHITLNGLVFVVNDS--TVNDARLLNPSDIF 369
            ||||||||||||.::|:...|.:::.||||..:.||:...|..||.|.:  |:..|:|..|  :.
  Fly   311 SPQLLMLSGIGPEDNLKAIGIPLIKALPVGKRMFDHMCHFGPTFVTNTTGQTLFAAQLGAP--VA 373

  Fly   370 RYIFAGQGPYTIP--GGAEAFAFVRTPSSKFAKDYPDMELVLGAGSLSGDRFGTMRNLLGITDEF 432
            :....|:....:.  ||.|...|::.||.|.....||:||:..||||:.|....:........|.
  Fly   374 KEFLLGRADTFLSSIGGVETLTFIKVPSGKSPATQPDVELIQVAGSLASDDGTALAKGANFKPEI 438

  Fly   433 YDYMFGD--LQSKETFGLVPVLLRPKSRGRISLRSRNPFHWPRMEPNFMQHPDDVRAMIEGIEMI 495
            |:.|:.:  |:.::.|..:.:..:|.|.||:.|.:|||..|||::|.:...|.||..::|||:..
  Fly   439 YEKMYKNLTLRQQDHFSFLIMHFKPASVGRLWLHNRNPLEWPRIDPKYFSAPSDVENLLEGIKEA 503

  Fly   496 LKLSRSKPMAKMGTRFHDRPFPGCENLKFASEAYWKCCLRRYGSSLQHQSGTCKMGPATDNTSVV 560
            |::|:...|..:|||..|:|.|||||.:|||:.||:|.:|....:|.||..||:||..:|.|:||
  Fly   504 LRISKMPAMQAIGTRLLDKPVPGCENYEFASDDYWRCSIRTLSYTLHHQVATCRMGAESDPTTVV 568

  Fly   561 DAQLRIHGIRGLRVVDASVLPNVPAGHTNAIVIMVAEKAGDMIKDAW 607
            :.||::||:|.|||||.|::|..|..||||...|:.|||.|||:..|
  Fly   569 NHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAADMIRSEW 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6142	NP_651466.1	PRK02106	47..604	CDD:235000	251/562 (45%)
		NADB_Rossmann	48..342	CDD:304358	147/294 (50%)
		GMC_oxred_C	455..599	CDD:282984	68/143 (48%)
CG9522	NP_644677.1	PRK02106	48..612	CDD:235000	251/562 (45%)
		NADB_Rossmann	52..>83	CDD:304358	19/30 (63%)
		NADB_Rossmann	127..348	CDD:304358	109/220 (50%)
		GMC_oxred_C	463..607	CDD:282984	68/143 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	8	8.060