DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6142 and CG12539

DIOPT Version :9

Sequence 1:	NP_651466.1	Gene:	CG6142 / 43178	FlyBaseID:	FBgn0039415	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_572976.1	Gene:	CG12539 / 32412	FlyBaseID:	FBgn0030586	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	257/579 - (44%)
Similarity:	361/579 - (62%)	Gaps:	10/579 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PDTTRFLPEYDFIIVGAGSAGCVMANRLSEISSASVLLLEAGDQETFISDVPLTAALTQMTRYNW 103
            |:..|.|..||||::|||:|||.:|.||||....||.|:|||..|......|:.|...|.|..||
  Fly    49 PNVPRDLSNYDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGVENIAHLTPVVAGYLQQTSSNW 113

  Fly   104 GYKAEPTEHACQGLKGGVCNWPKGRGVGGTSLINFMLYTRGHRRDYDEWAAANNSGWSYDELLPY 168
            |||:.|.:.:|.|:....|..|:|:.:||||.||:|:|.||:|||:|.||||.|.||||||:|||
  Fly   114 GYKSVPQKLSCHGMNNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPY 178

  Fly   169 FRKSERIGIPELYKSPYHGRNGQLDVQYTDYRSQLLKAFLKSGREMGYEITDPNGEHLMGFARSQ 233
            |.:||...:..|.:||||..:|.|.|:|..:|||::.||:::..|.|...||.|||..:|.:..|
  Fly   179 FLRSEHAQLQGLEQSPYHNHSGPLSVEYVRFRSQMVDAFVEASVESGLPRTDYNGESQLGVSYVQ 243

  Fly   234 ATIRNGRRCSTSKAFIQPVVN-RKNLHISMKSWVTRLIIDPITKTATGVEFVKQRQRYVVRARKE 297
            |...||||.|...|:|:||.: |.||.|...|.|||::||..||:|.||||..:.:.|..:||||
  Fly   244 ANTLNGRRHSAYSAYIKPVRDLRSNLQIFTFSQVTRILIDEATKSAYGVEFHYKNKAYTFKARKE 308

  Fly   298 VILSAGTIASPQLLMLSGIGPAEHLREHNITVMQDLPVGYNLQDHITLNGLVFVVNDS--TVNDA 360
            ||||||:..||||||||||||.::||...|.:::.||||..:.||:...|..||.|.:  |...:
  Fly   309 VILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALPVGKRMFDHMCHFGPTFVTNTTGQTTFTS 373

  Fly   361 RLLNPSDIFRYIFAGQGPYT---IPGGAEAFAFVRTPSSKFAKDYPDMELVLGAGSLSGDRFGTM 422
            | :.|:::..::.|| .|.|   ..||.||.||::|..|....|:||:||::..|||:.|....:
  Fly   374 R-VTPAELISFLLAG-NPATRMSSIGGVEALAFLKTQRSNLPNDWPDIELIMVTGSLASDEGTGL 436

  Fly   423 RNLLGITDEFYDYMFGDL--QSKETFGLVPVLLRPKSRGRISLRSRNPFHWPRMEPNFMQHPDDV 485
            :......||.||.|:.:|  ..::.|.|:.:...|||.||:.|:.|||..||:::|.:....:||
  Fly   437 KLGANFKDEIYDRMYRELAQAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDV 501

  Fly   486 RAMIEGIEMILKLSRSKPMAKMGTRFHDRPFPGCENLKFASEAYWKCCLRRYGSSLQHQSGTCKM 550
            ..:::||:..|::.....|.::|.|...|..||||..:|||:.||:|.:|....:|.||..||:|
  Fly   502 EYLLDGIKASLRIIEMPAMQRIGARLLKRTVPGCEGHQFASDDYWRCSIRTLSYTLHHQVATCRM 566

  Fly   551 GPATDNTSVVDAQLRIHGIRGLRVVDASVLPNVPAGHTNAIVIMVAEKAGDMIKDAWRM 609
            |..:|.|:||:.||::||:|.|||||.|::|..|..||||...|:.|||.|||:..|.:
  Fly   567 GAESDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAADMIRTDWEL 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6142	NP_651466.1	PRK02106	47..604	CDD:235000	252/564 (45%)
		NADB_Rossmann	48..342	CDD:304358	148/294 (50%)
		GMC_oxred_C	455..599	CDD:282984	62/143 (43%)
CG12539	NP_572976.1	PRK02106	58..620	CDD:235000	252/563 (45%)
		NADB_Rossmann	59..>90	CDD:304358	18/30 (60%)
		NADB_Rossmann	128..355	CDD:304358	116/226 (51%)
		GMC_oxred_C	471..615	CDD:282984	62/143 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.970