DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6142 and Chdh

DIOPT Version :9

Sequence 1:	NP_651466.1	Gene:	CG6142 / 43178	FlyBaseID:	FBgn0039415	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_942026.1	Gene:	Chdh / 290551	RGDID:	735166	Length:	599	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	205/579 - (35%)
Similarity:	296/579 - (51%)	Gaps:	67/579 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EYDFIIVGAGSAGCVMANRLSEISSASVLLLEAGDQETFISD------VPLTAALTQM---TRYN 102
            ||.||:|||||||||:||||:|..:..|||||||.::..:..      :.:.|||...   .:||
  Rat    45 EYTFIVVGAGSAGCVLANRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIHMPAALVANLCDDKYN 109

  Fly   103 WGYKAEPTEHACQGLKGGVCNWPKGRGVGGTSLINFMLYTRGHRRDYDEWAAANNSGWSYDELLP 167
            |.|..|    |..||.|.|..||:||..||:|.:|.|:|.|||..||:.|......||.|...||
  Rat   110 WYYHTE----AQPGLDGRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWHRQGAEGWDYAHCLP 170

  Fly   168 YFRKSERIGIPELYKSPYHGRNGQLDVQYTDYRSQLLKAFLKSGREMGYEIT-DPNGEHLMGFAR 231
            ||||:::   .||..:.|.|.:|.|.|........|.:|||::.|:.||..| |.||....||..
  Rat   171 YFRKAQK---HELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAGYPFTEDMNGFQQEGFGW 232

  Fly   232 SQATIRNGRRCSTSKAFIQPVVNRKNLHISMKSWVTRLIIDPITKTATGVEFVKQRQRYVVRARK 296
            ...||..|:|.||:.|:::|.::|.||...:::.|:|::.:  ...|.|||::|..|.:.....:
  Rat   233 MDMTIHQGKRWSTASAYLRPALSRPNLRAEVQTLVSRVLFE--GTRAVGVEYIKDGQSHKAYVSR 295

  Fly   297 EVILSAGTIASPQLLMLSGIGPAEHLREHNITVMQDLP-VGYNLQDHITLNGLVFVVNDSTVNDA 360
            |||||.|.|.|||||||||:|.|:.|::..|.|:..|| ||.|||||:.:..........|::.|
  Rat   296 EVILSGGAINSPQLLMLSGVGNADDLKKLGIPVVCHLPGVGQNLQDHLEIYIQHACTQPITLHSA 360

  Fly   361 R------LLNPSDIFRYIFAGQGPYTIPGGAEAFAFVRTPSSKFAKDYPDMEL-VLGAGSLSGDR 418
            :      .:....::|:...|...:...||     |:|   |:....:||::. .|.:..:...|
  Rat   361 QKPLRKVCIGLEWLWRFTGDGATAHLETGG-----FIR---SRPGVPHPDIQFHFLPSQVIDHGR 417

  Fly   419 FGTMRNLLGITDEFYDYMFGDLQSKETFGLVPVLLRPKSRGRISLRSRNPFHWPRMEPNFMQHPD 483
            ..|.:       |.|....|             .:|..|.|.:.|||.||...|.:.||::....
  Rat   418 KPTQQ-------EAYQVHVG-------------TMRATSVGWLKLRSTNPQDHPMINPNYLSTET 462

  Fly   484 DVRAMIEGIEMILKLSRSKPMAKMGTRFHDRPFPGCE---NLKFASEAYWKCCLRRYGSSLQHQS 545
            ||....:.:::..::...:..|         ||.|.|   .....|:......:|....|..|.|
  Rat   463 DVEDFRQCVKLTREIFAQEAFA---------PFRGKELQPGSHVQSDKEIDAFVRAKADSAYHPS 518

  Fly   546 GTCKMGPATDNTSVVDAQLRIHGIRGLRVVDASVLPNVPAGHTNAIVIMVAEKAGDMIK 604
            .|||||..:|.|:|||.|.|:.|:..|||:|||::|:|.:|:.||..||:||||.|:||
  Rat   519 CTCKMGQPSDPTAVVDQQTRVIGVENLRVIDASIMPSVVSGNLNAPTIMIAEKAADVIK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6142	NP_651466.1	PRK02106	47..604	CDD:235000	203/577 (35%)
		NADB_Rossmann	48..342	CDD:304358	129/304 (42%)
		GMC_oxred_C	455..599	CDD:282984	50/146 (34%)
Chdh	NP_942026.1	PRK02106	45..591	CDD:235000	205/579 (35%)
		NADB_Rossmann	49..>151	CDD:304358	48/105 (46%)
		GMC_oxred_N	121..344	CDD:279121	96/227 (42%)
		GMC_oxred_C	435..572	CDD:282984	50/145 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	244	1.000	Domainoid score	I2129
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2269
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm44531
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.880