DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pak4 and Pak

DIOPT Version :9

Sequence 1:	NP_001002222.2	Gene:	pak4 / 431769	ZFINID:	ZDB-GENE-040704-69	Length:	664	Species:	Danio rerio
Sequence 2:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	796	Identity:	250/796 - (31%)
Similarity:	354/796 - (44%)	Gaps:	167/796 - (20%)

- Green bases have known domain annotations that are detailed below.

Zfish     4 KKK--KQRIQ------------ISAPSNFEHRVHTDFDEQEQKFVGLPRQWQSLI-------EDT 47
            |||  |.:|:            ||.|:||||.||..||....:|.|:|..|..|:       ::.
  Fly    61 KKKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQ 125

Zfish    48 AKRPKPFIDATV----ITTVEPRKTIVRGRKIGDDGSLTWLLDEFETMSVIRSNS---------- 98
            .|.|:..:|...    .|...|....:........||         ::|.:.|:|
  Fly   126 KKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGS---------SLSRVSSSSPSSTPTDSEL 181

Zfish    99 -----------LRRGSPPLQPRSDSGSSGGHENGEH--PQYRHTDRYGDSKEREKPRQEHPGTDP 150
                       ::.||..|.|.:::.:..|...|.|  .|.:|..:.......:...|.|.|...
  Fly   182 HGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQ 246

Zfish   151 RQSQR-----------PGRSSREDG-----RPQQQPR----GQEPSRHKE--------------P 181
            ..|..           ...|:.||.     .|||||.    ...|.|.|.              |
  Fly   247 SHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIP 311

Zfish   182 DWITPGQHREREWDREREPRDYSDHVVRREGANDKRPKSSYTGRDSSPQSPREKRPLSGPNIRTP 246
            ..:.|...........|.|...|.........|:..........:::|.||...:..:    .|.
  Fly   312 MPVAPATTPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTA----ETE 372

Zfish   247 NLPVTEGVIKAAQQTGRPFNTYPRSESDSGRTPSGQDLKPAKSHEST------------HHNGPS 299
            ....|..::.|   |....:|.|.:: .:...|.|..::.|.:|.:|            ||:
  Fly   373 GTDATSTLLSA---TNPSCSTTPTTD-PAPAAPRGSLVETATAHATTAAATVATSTTTNHHS--- 430

Zfish   300 AGPVRGGSSSSSSGGGQTSSQGPHRSEPQHH------------ASHPALGPEPPHGQPMPPPPK- 351
                  .:||.||........|.|.:.|..|            .|.|...|.||...|..|.|.
  Fly   431 ------SASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPAS 489

Zfish   352 --------------------PSGPAAPSQ--------------PTRSPQREPQRVSHEQFRAALQ 382
                                ||...|.:|              .||:...:.:::|.|:....|:
  Fly   490 IESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLR 554

Zfish   383 MVVDPGDPRTYLDHYIKIGEGSTGIVCIATVKTTGKLVAVKKMDLRKQQRRELLFNEVVIMRDYH 447
            .:|..|||........|||:|::|.|..|...:||..||:|:|:|.:|.::||:.||:::||:..
  Fly   555 TIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENK 619

Zfish   448 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQISTVCLSVLKALSVLHSQGVIHR 512
            |.|||...:||||.:|||||||:|.||:|||:||.|.|:|.||:.||..||:||..||:..||||
  Fly   620 HPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHR 684

Zfish   513 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVQRRKSLVGTPYWMAPELISRLPYGPEVDIWSFGIM 577
            |||||:|||..||.|||:|||||||:|.|..:|.::||||||||||:::|..|||:||:||.|||
  Fly   685 DIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIM 749

Zfish   578 VIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNLHKVSPLLKGFLDRMLVRDPAQRATAQELLKH 642
            .||||:|||||.||.||||:.:|..|..|::|...|:|...:.|||:.|..:..:||:|.:||||
  Fly   750 AIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKH 814

Zfish   643 PFLTKAGPPSCIVPLM 658
            |||..|.|.:.:.||:
  Fly   815 PFLKLARPLASLTPLI 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pak4	NP_001002222.2	CRIB_PAK_like	12..>46	CDD:238526	16/40 (40%)
		STKc_PAK4	373..664	CDD:132988	151/286 (53%)
		S_TKc	399..645	CDD:214567	138/245 (56%)
Pak	NP_001138013.2	PBD	83..137	CDD:279166	19/53 (36%)
		STKc_PAK_I	558..818	CDD:270814	142/259 (55%)
		S_TKc	566..817	CDD:214567	138/250 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920