DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysf and npas4a

DIOPT Version :9

Sequence 1:	NP_733137.3	Gene:	dysf / 43174	FlyBaseID:	FBgn0039411	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	NP_001038786.1	Gene:	npas4a / 724016	ZFINID:	ZDB-GENE-060616-396	Length:	933	Species:	Danio rerio

Alignment Length:	889	Identity:	222/889 - (24%)
Similarity:	340/889 - (38%)	Gaps:	262/889 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 KSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVFKRHNAMH 219
            :|||||||.|||.|||||.||:||||:..:.:.|||.|.:|:|.|:|.||:.:|.|.....:
Zfish     3 RSTKGASKARRDQINAEIRNLKDLLPISDADKSRLSYLHIMSLACMYTRKSVFFSQDITTAS--- 64

  Fly   220 HLHHQTATPNIGF---------SKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGDSVY 275
                 :|....||         .:.:.|||::||..|||||:||:.:::|||||.||:..|||||
Zfish    65 -----SAEETTGFLSFYELNELIQGMPGFLLLLTGEGKLLYLSDSVSDHLGHSMVDLVAQGDSVY 124

  Fly   276 DIIDKQDHANIQAELNRNVPPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSLEGE 340
            ||||..||..:::.|   |||                      ||.:                 .
Zfish   125 DIIDTADHFIMRSNL---VPP----------------------TSPD-----------------T 147

  Fly   341 HRMFLCRMNVSRNARRQMRFGDQKVVLVQGHYLSFLPLCS------RNEPVFLATCTPIAMPET- 398
            .|:|.||.|.|::.|||.  ...|:||::...||..|..|      .:.||::..|.|:. |.|
Zfish   148 DRLFRCRFNTSKSVRRQS--AGNKLVLIRARCLSQTPSESSPGSYWTSNPVWVCFCAPLE-PHTS 209

  Fly   399 -------RECVVQGATN------VFTTIHSMDMKIAHIDKNGEFHLGYDKSTLQGTSWYNLIHSD 450
                   ||.....|..      .|.:.||.||::....::...:||.:...|:..|||:.:|..
Zfish   210 RGGTASDRESTSASALESSFFLPCFRSQHSRDMRLHEAQESVSVYLGLNVEILRSQSWYSFLHPQ 274

  Fly   451 NLTEAQKKHSLIIQSEQDRSCILLVRMQRSSGEYTWVHVVLQVRDSPDSTQQPVIVCTNQVLNDR 515
            :|:.|..:|..:::...:....::||::.:...:.|:::|||:     .|.:..||..|.::::.
Zfish   275 DLSHASAQHCSLLREGGEGRAEMVVRVETADHSWVWLYMVLQL-----ETGETPIVSNNYIISET 334

  Fly   516 EASIMLANSWLYHYYTVQSKIQFGMPLDSGIRVPPGTPSSGYYSPHSSHPP---ATPG------- 570
            ||       |.........:.|..:.|.|.   .....|....||.:...|   .|||
Zfish   335 EA-------WSVRQQLSSEQTQLSLVLGSS---TSQQESVSLQSPETLSSPDQVFTPGSSGLSGQ 389

  Fly   571 -----------GATPNLGIASSFGPHHHPHHSHHPHHHHHHHHPATAYHHHPHMGTYGGVYHAKA 624
                       |:|...|.:||..|   ......|..........|.:.|.|         ....
Zfish   390 SFDFSTAACSTGSTEEQGGSSSMEP---AQVESGPRSSLSSMEEETFFQHEP---------SEPM 442

  Fly   625 AIELKEDQPLFCFQEPVDYSQVN-------SHVNPPNATSTPNPPISKSSTPPPPKKRARKLE-- 680
            |.......|:     ||..:.|:       :.:.||.....|..|:.....||.|..:|::.:
Zfish   443 ASPSSASSPI-----PVTVATVSDLDFLTQNILLPPAFQIDPPLPVLPLPLPPVPTSQAQQTKEF 502

  Fly   681 ---PLYL-------------HAERSPAAAITPEPDCYAIHTHPAAAYATSSVVSSDASVIYATIV 729
               |.|.             |....|..|.:|.|           ...|::|.::.|    .::.
Zfish   503 VCTPPYTPQLGGSNFPFGEPHFSFDPTGATSPPP-----------LGQTATVTTTTA----PSLS 552

  Fly   730 PTRPRLPNKSLPPDPADFIEQWNP---SPPWSE---SAQKASLDSFGSSHELSPCITTTPPTPTS 788
            |:.|..|..| ||.|...:....|   :.|.:|   ..:..|    ||.:|      ..||||.|
Zfish   553 PSAPSNPQSS-PPPPTTTLSSLLPLTITSPTTEILFPVEPCS----GSLYE------KLPPTPDS 606

  Fly   789 ATPHQSGLGTTQTI----GPAFSFEWMSDPLVPVTYQQWPPTG---------------------D 828
            .   ..|..|..|:    ||.:    :..|..|:.|   ||.|                     |
Zfish   607 P---GDGDCTVMTLPEVRGPLY----VDVPHGPLPY---PPEGLLTPEASPGKQPSLPFFSSLRD 661

  Fly   829 HHQH------LSQHLSQ-------------------SQNHQNPLQQQQNEQLLLGQQPHLHQQHQ 868
            ..:.      |:||:|.                   |::.|:|.....:...|||:...| :..:
Zfish   662 REKERTEISLLAQHISTLAEGFYLDPLLAKLVPSTLSEHSQSPDSDGLDSIPLLGEFYPL-KSWK 725

  Fly   869 HLALHHGRGEHSLEGES------QGVVVVPPIPISIPIPTATGH 906
            .|.|...:.:.||..||      |.:...||:.   |.|:::.|
Zfish   726 GLDLPIFQDDESLFEESVLETLLQDLSSSPPLS---PTPSSSSH 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysf	NP_733137.3	PAS	235..292	CDD:214512	31/56 (55%)
		PAS	407..506	CDD:238075	22/104 (21%)
		PAS_11	408..517	CDD:291273	25/114 (22%)
npas4a	NP_001038786.1	Basic motif, degenerate. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	1..13		7/9 (78%)
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	14..53		21/38 (55%)
		PAS	77..139	CDD:214512	30/61 (49%)
		PAS_11	234..336	CDD:291273	25/106 (24%)
		PAS	238..321	CDD:238075	21/87 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..451		18/101 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..573		15/74 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	750..776		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596347
Domainoid	1	1.000	134	1.000	Domainoid score	I4969
eggNOG	1	0.900	-	-		E1_28JIU
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005466
OrthoInspector	1	1.000	-	-		otm25490
orthoMCL	1	0.900	-	-		OOG6_108359
Panther	1	1.100	-	-	LDO	PTHR23043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3266
SonicParanoid	1	1.000	-	-		X4418
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.730