Protein Alignment dysf and SIM2

DIOPT Version :10

• Sequence 1: NP_733137.3
• Gene: dysf / 43174
• FlyBaseID: FBgn0039411
• Length: 920
• Species: Drosophila melanogaster
• Sequence 2: NP_005060.1
• Gene: SIM2 / 6493
• HGNCID: 10883
• Length: 667
• Species: Homo sapiens
• Alignment Length: 744
• Identity: 164/744 - (22%)
• Similarity: 259/744 - (34%)
• Gaps: 175/744 - (23%)

  Fly   155 KSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVFKRHNAMH 219
            :.:|.|:|.||:..|.|...|..|||||.:...:|.:..::.|...|::    .:.||.......
Human     3 EKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK----MRAVFPEGLGDA 63

  Fly   220 HLHHQTATPNIGFSK--------ALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGDSVYD 276
            ......|.|..|.:|        .|.||:.::..:||::|||:.|:.:||.|..:|.  |:|:|:
Human    64 WGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT--GNSIYE 126

  Fly   277 IIDKQDHANIQAELNRNVPPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSLEGEH 341
            .|...||..:.|.|..:.|..                                     ..|..|:
Human   127 YIHPSDHDEMTAVLTAHQPLH-------------------------------------HHLLQEY 154

  Fly   342 ---RMFLCRMN---VSRNARRQMRFGDQKVVLVQGH-----YLSFLPLCSRNEPVFLATCTPIAM 395
               |.|..||.   ..|||  .:.....||:...|:     |:..:.|......:........::
Human   155 EIERSFFLRMKCVLAKRNA--GLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSL 217

  Fly   396 PETRECVVQGATNVFTTIHSMDMKIAHIDKNGEFHLGYDKSTLQGTSWYNLIHSDNLTEAQKKHS 460
            |.:....::..:|:|....|:|:|:..:|.......||:...|...:.|:.:|..::...:..|.
Human   218 PPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHH 282

  Fly   461 LIIQSEQDRSCILLVRMQRSSGEYTWVHVVLQVRDSPDSTQQPVIVCTNQVLND---REASIML- 521
            |::...|..:  ...|:....|.:.||.....|..:..|::...||..|.||.:   :|..:.|
Human   283 LLLVKGQVTT--KYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLE 345

  Fly   522 -------ANSWLYHYYTVQSKIQFGMPLDSGIRV-------PPGTPSS--------GYYSPHSSH 564
                   .:||.....|.|...:...|.::.::.       ||...||        |......:.
Human   346 QVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRAS 410

  Fly   565 PPATPGGATPNLGIASSFGPH-------HHPHHSHHPHHHHHHHHPATAYHHHPHMGTYGGVYHA 622
            |||: ..|.|.|      .||       :.|.:| .|..:|:.|.|..::           |:.:
Human   411 PPAS-AAAPPEL------QPHSESSDLLYTPSYS-LPFSYHYGHFPLDSH-----------VFSS 456

  Fly   623 -KAAIELKEDQP---------LFCFQEPVDYSQVNSHVNP--PNATSTPNPPISKSSTPPPPKKR 675
             |..:..|..||         .|....|........:.||  |:::|....|      |.||...
Human   457 KKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQWHYANPLVPSSSSPAKNP------PEPPANT 515

  Fly   676 AR-KLEPLYLHAERSPAAAI--------TPE-PDCYAIHTHPA--AAYATSSVVSSDASVIYATI 728
            || .|.|.|    .:||||:        .|. |.|......||  .|.|........|.:..|..
Human   516 ARHSLVPSY----EAPAAAVRRFGEDTAPPSFPSCGHYREEPALGPAKAARQAARDGARLALARA 576

  Fly   729 VPTRPRLPNKSLPPDPADF----------IEQWNP----SPPWSESA-----QKASLDSFGSSHE 774
            .|.....|....|..||..          :.:..|    :|..|..|     .:|:..:....|.
Human   577 APECCAPPTPEAPGAPAQLPFVLLNYHRVLARRGPLGGAAPAASGLACAPGGPEAATGALRLRHP 641

  Fly   775 LSPCITTTPPTPTSATPHQSGLGTTQTIG 803
             ||..|:.|..|   .||..|.....|.|
Human   642 -SPAATSPPGAP---LPHYLGASVIITNG 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dysf	NP_733137.3	bHLH-PAS_NPAS4_PASD10	154..210	CDD:381540	16/54 (30%)
		PAS	235..292	CDD:214512	21/56 (38%)
		PAS_11	407..517	CDD:464214	25/112 (22%)
SIM2	NP_005060.1	bHLH_SF	1..74	CDD:469605	20/74 (27%)
		PAS	79..140	CDD:214512	20/62 (32%)
		PAS_11	91..194	CDD:464214	32/143 (22%)
		PAS_3	243..329	CDD:430001	17/87 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..389		5/32 (16%)
		SIM_C	358..660	CDD:461963	74/334 (22%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:14697214	367..386		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..428		8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..520		7/25 (28%)