Protein Alignment dysf and NPAS4

DIOPT Version :9

• Sequence 1: NP_733137.3
• Gene: dysf / 43174
• FlyBaseID: FBgn0039411
• Length: 920
• Species: Drosophila melanogaster
• Sequence 2: XP_016873026.1
• Gene: NPAS4 / 266743
• HGNCID: 18983
• Length: 879
• Species: Homo sapiens
• Alignment Length: 849
• Identity: 210/849 - (24%)
• Similarity: 323/849 - (38%)
• Gaps: 261/849 - (30%)

  Fly   122 QQQPQTTQQQHATQQQ----QQQQQQTAGMFTRFDA------NKSTKGASKMRRDLINAEIANLR 176
            :|:...::::.:|:::    ..::::.:|  ||..|      .:|||||||.|||.|||||.||:
Human    39 EQRASLSERRGSTEEEAAGASGRERRCSG--TRAGAPQPPVMYRSTKGASKARRDQINAEIRNLK 101

  Fly   177 DLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVFKRHNAMHHLHHQTATPNIG---------- 231
            :||||.::.:.|||.|.:|:|.|:|.||..:|               ...||..|
Human   102 ELLPLAEADKVRLSYLHIMSLACIYTRKGVFF---------------AGGTPLAGPTGLLSAQEL 151

  Fly   232 --FSKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGDSVYDIIDKQDHANIQAELNRNV 294
              ...||.|||::.|..|||||:|::.:|:|||||.||:..|||:|||||..||..::.:|  .:
Human   152 EDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQL--TL 214

  Fly   295 PPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSLEGEHRMFLCRMNVSRNARRQMR 359
            |                                       |:|:.: |:|.||.|.|::.|||.
Human   215 P---------------------------------------SALDTD-RLFRCRFNTSKSLRRQS- 238

  Fly   360 FGDQKVVLVQGHYLSFLP-LCSRNEPVFLATCTPIAMPETRECVVQGA------TNVFTTIHSMD 417
             ...|:||::|.:.:..| ......|||.|.|.|:. |..|.....|.      ..:|.:.|:.|
Human   239 -AGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLE-PRPRPGPGPGPGPASLFLAMFQSRHAKD 301

  Fly   418 MKIAHIDKNGEFHLGYDKSTLQGTSWYNLIHSDNLTEAQKKHSLIIQSEQDRSCILLVRMQRSSG 482
            :.:..|.::...:||:::|.|...|||.|:|.::|..|..:|..::....|....::||:|..:|
Human   302 LALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTG 366

  Fly   483 EYTWVHVVLQVRDSPDSTQQPVIVCTNQVLNDREASIMLANSWLYHYYTVQSKIQFGMPLDSGIR 547
            .:.|::.:| ..:.|:..    |...|..::|.||       |...........|....|
Human   367 GWAWIYCLL-YSEGPEGP----ITANNYPISDMEA-------WSLRQQLNSEDTQAAYVL----- 414

  Fly   548 VPPGTPSSGYYSPHSSHPPATPGGATPNLGIASSFGPHHHPHHSHHPHHHHHHHHPATAYHHHPH 612
               |||:                       :..||                    |.......
Human   415 ---GTPT-----------------------MLPSF--------------------PENILSQE-- 431

  Fly   613 MGTYGGVYHAKAAIELKEDQPLFCFQEPVDYSQVNSHVNPPNATSTPNPP----ISKSSTPPPPK 673
                          |.....|||           .:.:..|.:||.|:.|    :|.|...|.|.
Human   432 --------------ECSSTNPLF-----------TAALGAPRSTSFPSAPELSVVSASEELPRPS 471

  Fly   674 KRARKLEPLY----------LHAERSPAAAITPEPDCYAIHTHPAAAYATSSVVSSDASVIYATI 728
            |   :|:..|          |.||.|.....||.   |..|.....|:..|      ....:.|.
Human   472 K---ELDFSYLTFPSGPEPSLQAELSKDLVCTPP---YTPHQPGGCAFLFS------LHEPFQTH 524

  Fly   729 VPTRPRLPNKSLPPDPADFIEQWNPS---------PPWSESAQKASLDSFGSSHELSPCITTTPP 784
            :||......:.|.|..|.|.:|..||         .|......:.|:.|:  ..:|:||.:|.|.
Human   525 LPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSY--EDQLTPCTSTFPD 587

  Fly   785 --TPTSATPHQSGLGTTQTIGPAFSFEWMSDPL-VPVTYQQWPPTGDHHQHLSQHLSQS---QNH 843
              .|::||                    ..:|| .|...|..||:.....||... ||:   |..
Human   588 QLLPSTAT--------------------FPEPLGSPAHEQLTPPSTAFQAHLDSP-SQTFPEQLS 631

  Fly   844 QNPLQ---QQQNEQLLLGQQPHLHQQHQH-----LALHHGRGEHSLEGESQGVVVVPPIPISIPI 900
            .||.:   .|:....|..:.|.......:     |||...||..|::        ||.:|..:..
Human   632 PNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVD--------VPLVPEGLLT 688

  Fly   901 PTAT 904
            |.|:
Human   689 PEAS 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dysf	NP_733137.3	PAS	235..292	CDD:214512	31/56 (55%)
		PAS	407..506	CDD:238075	24/98 (24%)
		PAS_11	408..517	CDD:291273	27/108 (25%)
NPAS4	XP_016873026.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160043
Domainoid	1	1.000	134	1.000	Domainoid score	I5029
eggNOG	1	0.900	-	-		E1_28JIU
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3676
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005466
OrthoInspector	1	1.000	-	-		oto89767
orthoMCL	1	0.900	-	-		OOG6_108359
Panther	1	1.100	-	-	LDO	PTHR23043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4418
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.750