DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysf and Npas4

DIOPT Version :9

Sequence 1:	NP_733137.3	Gene:	dysf / 43174	FlyBaseID:	FBgn0039411	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	NP_705890.1	Gene:	Npas4 / 266734	RGDID:	628866	Length:	802	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	216/849 - (25%)
Similarity:	329/849 - (38%)	Gaps:	248/849 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 KSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVFKRHNAMH 219
            :|||||||.|||.|||||.||::||||.::.:.|||.|.:|:|.|:|.||..:|
  Rat     3 RSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF----------- 56

  Fly   220 HLHHQTATPNIG------------FSKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGD 272
                ...||..|            ...||.|||::.|..|||||:|::.:|:|||||.||:..||
  Rat    57 ----AGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGD 117

  Fly   273 SVYDIIDKQDHANIQAELNRNVPPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSL 337
            |:|||||..||..::.:|  .:|                                       |:|
  Rat   118 SIYDIIDPADHLTVRQQL--TMP---------------------------------------SAL 141

  Fly   338 EGEHRMFLCRMNVSRNARRQMRFGDQKVVLVQGHYLSFLP-LCSRNEPVFLATCTPIAMPETREC 401
            :.: |:|.||.|.|::.|||.  ...|:||::|.:.:..| ......|||.|.|.|:. |..|..
  Rat   142 DAD-RLFRCRFNTSKSLRRQS--AGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLE-PRPRPG 202

  Fly   402 VVQGA--------TNVFTTIHSMDMKIAHIDKNGEFHLGYDKSTLQGTSWYNLIHSDNLTEAQKK 458
            ...|.        ..:|.:.|:.|:.:..|.::...:||:::|.|...|||.|:|.::|..|..:
  Rat   203 PGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASSQ 267

  Fly   459 HSLIIQSEQDRSCILLVRMQRSSGEYTWVHVVLQVRDSPDSTQQPVIVCTNQVLNDREASIMLAN 523
            |..::....|....::||:|...|.:||::.:| ..|.|:..    |...|..::|.||
  Rat   268 HYRLLAENGDIQAEMVVRLQAKHGGWTWIYCML-YSDGPEGP----ITANNYPISDTEA------ 321

  Fly   524 SWLYHYY----TVQSKIQFGMPLDSGIRVPPGTPSSGYYSPHSSHPPATPGGATPNLGIASSFGP 584
             |.....    ..|:....|.|     .|.|....:.:...|.|:|..||...||.
  Rat   322 -WSLRQQLNSENTQAAYVLGTP-----AVLPSFSENVFSQEHCSNPLFTPALGTPR--------- 371

  Fly   585 HHHPHHSHHPHHHHHHHHPATAYHHHPHMGTYGGVYHAKAAIELKED--QPLFCFQEPVDYSQVN 647
                               :.::...|.:|          .|...|:  ||    .:.:|:|.:.
  Rat   372 -------------------SASFPRAPELG----------VISTSEELAQP----SKELDFSYLP 403

  Fly   648 SHVNP-PNATS------------TPNPPIS-----------KSSTPPPPKKRARKLEP--LYLHA 686
            ....| |:..:            ||:.|..           ::..|||......:|.|  :....
  Rat   404 FPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPPPSSSLQEQLTPSTVTFSE 468

  Fly   687 ERSPAAAITPEPDCYAIHTHPAAAYATSS----VVSSDASVIYATIVPTRPRLPNKSLP-----P 742
            :.:|::|..|:|             .|||    :..|.|......:.|.....|::.||     |
  Rat   469 QLTPSSATFPDP-------------LTSSLQGQLTESSARSFEEQLTPCTSTFPDQLLPSTATFP 520

  Fly   743 DPADFIEQWNPSPPWSESAQKASLDSFGSS--HELSPCITTT--------------PPTPTSATP 791
            :|.........:||  .:|.:|.|:|...:  .:|||..|.|              ||:|:|  |
  Rat   521 EPLGSPTHEQLTPP--STAFQAHLNSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSS--P 581

  Fly   792 HQSG---LGTTQTIGPAFSFEWMSDPLVP---VTYQQWPPTGDHHQHLSQHLSQSQNHQNPLQQQ 850
            ....   |...|..||..    :..||||   :|.:..|            :.||..|....:|.
  Rat   582 GNGDCTLLALAQLRGPLS----VDVPLVPEGLLTPEASP------------VKQSFFHYTEKEQN 630

  Fly   851 QNEQLLLGQQPHLHQQHQHLALHHGRGEHSLEGESQGVVVVPPIPISIPIPTATGHGDAGEPVED 915
            :.::|:        ||...||....| ..|.|..:.|   :.|:....|:........||.||..
  Rat   631 EIDRLI--------QQISQLAQGMDR-PFSAEAGTGG---LEPLGGLEPLNPNLSLSGAGPPVLS 683

  Fly   916 RDPK 919
            .|.|
  Rat   684 LDLK 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysf	NP_733137.3	PAS	235..292	CDD:214512	31/56 (55%)
		PAS	407..506	CDD:238075	26/98 (27%)
		PAS_11	408..517	CDD:291273	29/108 (27%)
Npas4	NP_705890.1	Basic motif, degenerate. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	1..13		7/9 (78%)
		bHLH-PAS_NPAS4_PASD10	2..57	CDD:381540	32/68 (47%)
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	14..53		21/38 (55%)
		PAS	72..135	CDD:214512	30/62 (48%)
		PAS_3	230..>298	CDD:369881	20/67 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..555		22/97 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354111
Domainoid	1	1.000	135	1.000	Domainoid score	I4849
eggNOG	1	0.900	-	-		E1_28JIU
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005466
OrthoInspector	1	1.000	-	-		oto96882
orthoMCL	1	0.900	-	-		OOG6_108359
Panther	1	1.100	-	-	LDO	PTHR23043
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.700