DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dysf and Npas4

DIOPT Version :9

Sequence 1:NP_733137.3 Gene:dysf / 43174 FlyBaseID:FBgn0039411 Length:920 Species:Drosophila melanogaster
Sequence 2:NP_705781.1 Gene:Npas4 / 225872 MGIID:2664186 Length:802 Species:Mus musculus


Alignment Length:846 Identity:214/846 - (25%)
Similarity:325/846 - (38%) Gaps:259/846 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 KSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVFKRHNAMH 219
            :|||||||.|||.|||||.||::||||.::.:.|||.|.:|:|.|:|.||..:|           
Mouse     3 RSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF----------- 56

  Fly   220 HLHHQTATPNIG------------FSKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGD 272
                ...||..|            ...||.|||::.|..|||||:|::.:|:|||||.||:..||
Mouse    57 ----AGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGD 117

  Fly   273 SVYDIIDKQDHANIQAELNRNVPPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSL 337
            |:|||||..||..::.:|  .:|                                       |:|
Mouse   118 SIYDIIDPADHLTVRQQL--TMP---------------------------------------SAL 141

  Fly   338 EGEHRMFLCRMNVSRNARRQMRFGDQKVVLVQGHYLSFLP-LCSRNEPVFLATCTPIAMPETREC 401
            :.: |:|.||.|.|::.|||.  ...|:||::|.:.:..| ......|||.|.|.|:. |..|..
Mouse   142 DAD-RLFRCRFNTSKSLRRQS--SGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLE-PRPRPG 202

  Fly   402 VVQGA--------TNVFTTIHSMDMKIAHIDKNGEFHLGYDKSTLQGTSWYNLIHSDNLTEAQKK 458
            ...|.        ..:|.:.|:.|:.:..:.::...:||:::|.|...|||.|:|.::|.:|..:
Mouse   203 PGPGPGPGPASLFLAMFQSRHAKDLALLDVSESVLIYLGFERSELLCKSWYGLLHPEDLAQASSQ 267

  Fly   459 HSLIIQSEQDRSCILLVRMQRSSGEYTWVHVVLQVRDSPDSTQQPVIVCTNQVLNDREASIMLAN 523
            |..::....|....::||:|...|.:||::.:| ..:.|:..    ....|..::|.||      
Mouse   268 HYRLLAESGDIQAEMVVRLQAKHGGWTWIYCML-YSEGPEGP----FTANNYPISDTEA------ 321

  Fly   524 SWLYHYY----TVQSKIQFGMPLDSGIRVPPGTPSSGYYSPHSSHPPATPGGAT---------PN 575
             |.....    ..|:....|.|     .|.|....:.:.....|:|..||...|         |.
Mouse   322 -WSLRQQLNSEDTQAAYVLGTP-----AVLPSFSENVFSQEQCSNPLFTPSLGTPRSASFPRAPE 380

  Fly   576 LGIASSFGPHHHPHHSHHPHHHHHHHHPATAYHHHPHMGTYGGVYHAKAAIELKED--QPLFCFQ 638
            ||:.|:  |...|..|..           ..:.:.|        :.|:....|:.|  :.|.|  
Mouse   381 LGVIST--PEELPQPSKE-----------LDFSYLP--------FPARPEPSLQADLSKDLVC-- 422

  Fly   639 EPVDYSQVNSHVNPPNATSTPNPPIS-----------KSSTPPPPKKRARKLEP--LYLHAERSP 690
                        .||   .||:.|..           ::..|||......:|.|  :....:.:|
Mouse   423 ------------TPP---YTPHQPGGCAFLFSLHEPFQTHLPPPSSSLQEQLTPSTVTFSEQLTP 472

  Fly   691 AAAITPEPDCYAIHTHPAAAYATSS----VVSSDASVIYATIVPTRPRLPNKSLP-----PDPAD 746
            ::|..|:|             .|||    :..|.|......:.|.....|::.||     |:|..
Mouse   473 SSATFPDP-------------LTSSLQGQLTESSARSFEDQLTPCTSSFPDQLLPSTATFPEPLG 524

  Fly   747 FIEQWNPSPPWSESAQKASLDSFGSS--HELSPCITTT--------------PPTPTSATPHQSG 795
            .......:||  .:|.:|.|:|...:  .:|||..|.|              ||:|:|  |....
Mouse   525 SPAHEQLTPP--STAFQAHLNSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSS--PGNGD 585

  Fly   796 ---LGTTQTIGPAFSFEWMSDPLVP---VTYQQWPPTGDHHQHLSQHLSQSQNHQNPLQQQQNEQ 854
               |...|..||..    :..||||   :|.:..|            :.||..|....:|.:.::
Mouse   586 CTLLALAQLRGPLS----VDVPLVPEGLLTPEASP------------VKQSFFHYTEKEQNEIDR 634

  Fly   855 LLLGQQPHLHQQHQHLALHHGRGEHSLEGESQGVVVVPPIPISIPIPTATGHGDAGEPVEDRDPK 919
            |:        ||...||              |||        ..|.....|.|.. ||:...:|.
Mouse   635 LI--------QQISQLA--------------QGV--------DRPFSAEAGTGGL-EPLGGLEPL 668

  Fly   920 N 920
            |
Mouse   669 N 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dysfNP_733137.3 PAS 235..292 CDD:214512 31/56 (55%)
PAS 407..506 CDD:238075 24/98 (24%)
PAS_11 408..517 CDD:291273 26/108 (24%)
Npas4NP_705781.1 Basic motif, degenerate. /evidence=ECO:0000255|PROSITE-ProRule:PRU00981 1..13 7/9 (78%)
bHLH-PAS_NPAS4_PASD10 2..57 CDD:381540 32/68 (47%)
Helix-loop-helix motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00981 14..53 21/38 (55%)
PAS 72..135 CDD:214512 30/62 (48%)
PAS_3 230..>298 CDD:369881 19/67 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 470..554 21/98 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850412
Domainoid 1 1.000 135 1.000 Domainoid score I4960
eggNOG 1 0.900 - - E1_28JIU
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005466
OrthoInspector 1 1.000 - - oto93339
orthoMCL 1 0.900 - - OOG6_108359
Panther 1 1.100 - - LDO PTHR23043
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3266
SonicParanoid 1 1.000 - - X4418
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.730

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