DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysf and npas4b

DIOPT Version :9

Sequence 1:	NP_733137.3	Gene:	dysf / 43174	FlyBaseID:	FBgn0039411	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	XP_009293710.2	Gene:	npas4b / 100534657	ZFINID:	ZDB-GENE-091117-33	Length:	844	Species:	Danio rerio

Alignment Length:	831	Identity:	210/831 - (25%)
Similarity:	315/831 - (37%)	Gaps:	247/831 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 FTRF----DANKSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYF 208
            |.||    ...:|||||||.|||.|||||.:|::|||:..:.:.|||.|.:|:|.|:|.||:.:|
Zfish    53 FQRFFGLEKMYRSTKGASKARRDQINAEIRSLKELLPISDADKARLSYLHIMSLACIYTRKSVFF 117

  Fly   209 QQVFKRHNAMHHLHHQTATPNIG-FSKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGD 272
            .|....|.....|   .:.|.:. ....|.|||::||..|||||:|||.||:|||||.||:...|
Zfish   118 SQAAAGHGMSGSL---LSLPELSDLLHTLPGFLLVLTSEGKLLYLSDNVAEHLGHSMVDLVAQSD 179

  Fly   273 SVYDIIDKQDHANIQAELNRNVPPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSL 337
            |||||||..||..::..|.....|.
Zfish   180 SVYDIIDPVDHFIMRGNLVPITTPD---------------------------------------- 204

  Fly   338 EGEHRMFLCRMNVSRNARRQMRFGDQKVV----LVQGHYLSFLPLCSRNEPVFLATCTPI--AMP 396
              ..|:|.||.:.|:..|||.....|.:|    |...::.|  |..:.| ||::..|:|:  :||
Zfish   205 --TDRLFRCRFSTSKFVRRQGSGNKQAIVRARCLPPPYHAS--PYWTSN-PVWVCFCSPLEASMP 264

  Fly   397 E---------TRECVVQGATNVFTTIHSMDMKIAHIDKNGEFHLGYDKSTLQGTSWYNLIHSDNL 452
            :         |.........:.|.:.||.||:|..:..:...:||||..||:..|||:|||..:|
Zfish   265 QLSTSRNPLPTPPAEQSFLLSCFQSQHSRDMRIHTVQDSVSVYLGYDIETLRSRSWYSLIHPRDL 329

  Fly   453 TEAQKKHSLIIQSEQDRSCILLVRMQRSSGEYTWVHVVLQVRDSPDSTQQPVIVCTNQVLNDREA 517
            :.|..:|..::.:..:|...::|:::.:...:.|:::|||:     .|.:..|...|.|:::.||
Zfish   330 SHASAQHCTLLHNGGERQVEMVVQVEAADHSWIWLYIVLQL-----ETGEYPINSHNYVISESEA 389

  Fly   518 SIMLANSW---------------LYHYYTVQSKIQFGMPLDSGIRVPPGTPSSGYYSPHS----- 562
                   |               ||     |...|...||.|..:|  .||||...|..|
Zfish   390 -------WSVRQQLHSEQNQLALLY-----QESRQSSDPLSSPDQV--FTPSSSGLSSQSFDFSF 440

  Fly   563 -----SHPPATPGGATPNLGIASSFGPHHHPHHSHHPHHHHHHHHPATAYHHHPHMGTYGGVYHA 622
                 |.....||.:.|:   :.:|.|..........|.                    ||....
Zfish   441 ITSGRSSSEELPGTSAPS---SMTFDPLEGEEIDPQSHG--------------------GGHQMW 482

  Fly   623 KAAIELKEDQPLFCFQEPVDYSQVNSHVNPPNATSTPNPPISKSSTPP---PPKKRARKLEPLYL 684
            ::|:.:..:                 |::..|.::.|...::....||   |||:
Zfish   483 RSAMTIAPE-----------------HLSNINLSTVPQSQVAPPPLPPFKAPPKR---------- 520

  Fly   685 HAERSPAAAITPEPDCYAIHTHPAAAYATSSVVSSDASVIYATIVPTRPRLPNKSLPPDPADFI- 748
              :||.....||                                 |..|||...|       ||
Zfish   521 --QRSEEFICTP---------------------------------PYTPRLSGGS-------FIF 543

  Fly   749 --EQWNPSPPWSESAQKASLDSFGSSHELSPC----ITTTPPTPTSATPHQSGLGTTQTI-GPAF 806
              |...||.....:..:.|:.|..:.....||    ..|.||||.|....:..|.....| ||.:
Zfish   544 NDETLRPSDHSKSAKMRQSITSATNIGPAQPCRKRLYETLPPTPDSPGSDECILMALPEIRGPLY 608

  Fly   807 SFEWMSDPLVPVTYQQWPPTGDHHQHLSQHLSQSQN-------HQNPLQQQQNEQLLLGQQ---- 860
                :..|.:|.   ..||.|    .|:...|.::.       .::..::::.|..||.|.
Zfish   609 ----VDVPHLPF---HAPPEG----LLTPEASPTKKPCLSFFPREDETERERMEISLLAQYISTL 662

  Fly   861 ----PHLHQQHQHLALHHGRGEHS----LEGESQGV--VVVPPIPISIPIP 901
                .|.|.|......||.....:    |..|.:.|  :.:|.:|...|:|
Zfish   663 AEGFCHNHPQGASAPPHHANSSLAHIDVLMFEEKAVDDIPLPNLPSPSPVP 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysf	NP_733137.3	PAS	235..292	CDD:214512	34/56 (61%)
		PAS	407..506	CDD:238075	28/98 (29%)
		PAS_11	408..517	CDD:291273	31/108 (29%)
npas4b	XP_009293710.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4969
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005466
OrthoInspector	1	1.000	-	-		otm25490
orthoMCL	1	0.900	-	-		OOG6_108359
Panther	1	1.100	-	-	O	PTHR23043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.910