Protein Alignment Sld5 and GINS4

DIOPT Version :10

• Sequence 1: NP_651457.1
• Gene: Sld5 / 43166
• FlyBaseID: FBgn0039403
• Length: 228
• Species: Drosophila melanogaster
• Sequence 2: NP_115712.1
• Gene: GINS4 / 84296
• HGNCID: 28226
• Length: 223
• Species: Homo sapiens
• Alignment Length: 225
• Identity: 86/225 - (38%)
• Similarity: 139/225 - (61%)
• Gaps: 14/225 - (6%)

  Fly    13 EIDVSDGAGLEDEDDDDMEQI--TAQKVLEIIETAWINEMCAPEILPSQTDMLELMVSQVAHMEE 75
            |:|.     |..:.|...|::  |..:::|.:|.||:||..|||:|.|:.:::|.::.|:.||||
Human     4 EVDF-----LGQDSDGGSEEVVLTPAELIERLEQAWMNEKFAPELLESKPEIVECVMEQLEHMEE 63

  Fly    76 QMRDLDKNDFRAVVHSMELERVRYIMASYLRCRLQKIETFTQHILNQEESR-EPDDKRLSPEETK 139
            .:|...:.|.:..:|.||:||:||:::|||||||.|||.|..|:|.:|::| |.:...|||||..
Human    64 NLRRAKREDLKVSIHQMEMERIRYVLSSYLRCRLMKIEKFFPHVLEKEKTRPEGEPSSLSPEELA 128

  Fly   140 FAQEFASNVDEYFHKVATQYM-PNQQRGEAEQRIVTPNLMSHVFLKANVAVPAVIVGVDDEE--- 200
            ||:||.:|.:.|...||.::| ||.|:.:..:.:..|:|.|:|||:.......::|..|.:|
Human   129 FAREFMANTESYLKNVALKHMPPNLQKVDLFRAVPKPDLDSYVFLRVRERQENILVEPDTDEQRD 193

  Fly   201 --VDMAAGSQHIIPYQLVADLIQNNQAQLI 228
              :|:..||||:|.|:.:|.|:.:...|||
Human   194 YVIDLEKGSQHLIRYKTIAPLVASGAVQLI 223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sld5	NP_651457.1	GINS_A_Sld5	38..156	CDD:212549	53/118 (45%)
		GINS_B_Sld5	175..228	CDD:412028	19/57 (33%)
GINS4	NP_115712.1	GINS_A_Sld5	26..146	CDD:212549	54/119 (45%)
		GINS_B_Sld5	165..223	CDD:412028	19/57 (33%)
		Important for GINS complex assembly	166..223		18/56 (32%)