DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dak1 and CMPK1

DIOPT Version :9

Sequence 1:	NP_651456.1	Gene:	Dak1 / 43165	FlyBaseID:	FBgn0028833	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_057392.1	Gene:	CMPK1 / 51727	HGNCID:	18170	Length:	228	Species:	Homo sapiens

Alignment Length:	196	Identity:	116/196 - (59%)
Similarity:	147/196 - (75%)	Gaps:	6/196 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 KPKIVFVLGGPGAGKGTQCSRIVDRFQFTHLSAGDLLREERSREGSEFGNLIEDYIRNGKIVPVE 126
            ||.:|||||||||||||||:|||:::.:||||||:|||:||....|::|.|||.||:.|||||||
Human    34 KPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVE 98

  Fly   127 VTCSLLENAMKA-----SGKSRFLIDGFPRNQDNLDGWNRQMSEKVDFQFVLFFDCGEDVCVKRC 186
            :|.|||:..|..     :.|::|||||||||||||.|||:.|..|.|..|||||||..::|::||
Human    99 ITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIERC 163

  Fly   187 LGRGQSGSGRTDDNLDSLKKRISTYNNDSLPIIKFFEGAGQVKRIDASPDAEEVFGEVEKIFVAS 251
            |.||:| |||:|||.:||:|||.||...:.|||..:|..|:||:||||...:|||.||.:||...
Human   164 LERGKS-SGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKSVDEVFDEVVQIFDKE 227

  Fly   252 G 252
            |
Human   228 G 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dak1	NP_651456.1	UMP_CMP_kin_fam	65..249	CDD:273576	112/188 (60%)
Dak1	NP_651456.1	ADK	65..240	CDD:238713	106/179 (59%)
CMPK1	NP_057392.1	UMP_CMP_kin_fam	37..225	CDD:273576	112/188 (60%)
CMPK1	NP_057392.1	ADK	37..216	CDD:238713	106/179 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	202	1.000	Domainoid score	I2999
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32308
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3390
Isobase	1	0.950	-	0	Normalized mean entropy	S511
OMA	1	1.010	-	-		QHG54223
OrthoDB	1	1.010	-	-		D1378291at2759
OrthoFinder	1	1.000	-	-		FOG0002780
OrthoInspector	1	1.000	-	-		oto89766
orthoMCL	1	0.900	-	-		OOG6_100591
Panther	1	1.100	-	-	LDO	PTHR23359
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1604
SonicParanoid	1	1.000	-	-		X1636
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820