DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dak1 and Ak8

DIOPT Version :9

Sequence 1:	NP_651456.1	Gene:	Dak1 / 43165	FlyBaseID:	FBgn0028833	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_001004266.1	Gene:	Ak8 / 311833	RGDID:	1303144	Length:	479	Species:	Rattus norvegicus

Alignment Length:	271	Identity:	63/271 - (23%)
Similarity:	103/271 - (38%)	Gaps:	75/271 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LRAVANDCGSPGVGLAPSALTQHQLRHSKASNRFITTTSTAPPHNIGIMSVEKPKIVFVLGGP-G 73
            |:.:::|  .|.|.:...|||..|..|          ...||         ..||:  :|.|| |
  Rat   237 LKTISSD--QPCVDVFYQALTYVQSGH----------RCNAP---------FTPKV--LLCGPMG 278

  Fly    74 AGKGTQCSRIVDRFQFTHLSAGDLLREERSREGSEFGNLIEDYIRNGKIVPVEVTCSLLENAMKA 138
            .||..|.:.:..::...::|.|.||:|..:.| |..|:|||.:......||..:...:|...:|.
  Rat   279 CGKKLQAALLSQKYGLVNISCGQLLKEAMAAE-SSLGDLIEPFFEKRMTVPDSIITRVLTERLKQ 342

  Fly   139 SG--KSRFLIDGFPRNQD-----NLDGW--NRQMSEKVDFQFVLFFDCGEDVCVKRCLGRGQSGS 194
            ..  :..:::.||||:.|     |..|:  ||          |.|.:...|..::|...|
  Rat   343 QDCIQKGWVLHGFPRDLDQARLLNSMGYSPNR----------VFFLNVPLDSILERLTLR----- 392

  Fly   195 GRTDDNLD-------------SLKKRISTYNNDSLPIIK-----FFEGAGQVKR-------IDAS 234
             |||....             .::.|:.....||...||     |:..:|.:::       ::..
  Rat   393 -RTDPVTGERFHLMYKPPPTIEVQARLLQNPKDSEEYIKLQTDLFYRNSGDLEQYYDRAIIVNGD 456

  Fly   235 PDAEEVFGEVE 245
            .|...||..:|
  Rat   457 QDPYTVFEYIE 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dak1	NP_651456.1	UMP_CMP_kin_fam	65..249	CDD:273576	50/216 (23%)
Dak1	NP_651456.1	ADK	65..240	CDD:238713	47/209 (22%)
Ak8	NP_001004266.1	Adenylate kinase 1. /evidence=ECO:0000250\|UniProtKB:Q96MA6	58..258		7/22 (32%)
		adk	59..258	CDD:273569	7/22 (32%)
		ADK	59..249	CDD:238713	4/13 (31%)
		NMP 1. /evidence=ECO:0000250\|UniProtKB:P69441	87..113
		LID 1. /evidence=ECO:0000250\|UniProtKB:P69441	177..206
		Adenylate kinase 2. /evidence=ECO:0000250\|UniProtKB:Q96MA6	269..471		52/218 (24%)
		adk	270..468	CDD:273569	51/217 (24%)
		ADK	270..462	CDD:238713	48/210 (23%)
		NMP 2. /evidence=ECO:0000250\|UniProtKB:P69441	298..327		11/29 (38%)
		LID 2. /evidence=ECO:0000250\|UniProtKB:P69441	391..424		5/38 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900