Protein Alignment Cmpk and AK5

DIOPT Version :10

• Sequence 1: NP_651456.1
• Gene: Cmpk / 43165
• FlyBaseID: FBgn0028833
• Length: 253
• Species: Drosophila melanogaster
• Sequence 2: NP_777283.1
• Gene: AK5 / 26289
• HGNCID: 365
• Length: 562
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 81/200 - (40%)
• Similarity: 119/200 - (59%)
• Gaps: 12/200 - (6%)

  Fly    56 GIM-SVEKPKIVFVLGGPGAGKGTQCSRIVDRFQFTHLSAGDLLREERSREGSEFGNLIEDYIRN 119
            |.| .:.|.||:|::||||:||||||.::|:::.|||||.|:|||||.:.| ||...||.|.:..
Human   368 GFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASE-SERSKLIRDIMER 431

  Fly   120 GKIVPVEVTCSLLENAMKAS-GKSR-FLIDGFPRNQDNLDGWNRQMSEKVDFQFVLFFDCGEDVC 182
            |.:||..:...||:.||.|| |.:| |||||:||.....:.:.|::.   |.|.|:..||..|..
Human   432 GDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIG---DPQLVICMDCSADTM 493

  Fly   183 VKRCLGRGQSGSGRTDDNLDSLKKRISTYNNDSLPIIKFFEGAGQVKRIDASPDAEEVFGE---- 243
            ..|.|.|.:| |...||...::.||:..|...|:|:|.::|...|:.:|:|....|:||.:
Human   494 TNRLLQRSRS-SLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTA 557

  Fly   244 VEKIF 248
            ::.||
Human   558 IDSIF 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cmpk	NP_651456.1	UMP_CMP_kin_fam	65..249	CDD:273576	76/189 (40%)
AK5	NP_777283.1	DD_AK5	3..46	CDD:438547
		Adenylate kinase 1. /evidence=ECO:0000305|PubMed:19647735	133..316
		ADK	134..307	CDD:238713
		NMP 1. /evidence=ECO:0000250|UniProtKB:P00568	162..193
		LID 1. /evidence=ECO:0000250|UniProtKB:P00568	256..266
		aden_kin_iso1	374..561	CDD:130427	77/191 (40%)
		Adenylate kinase 2. /evidence=ECO:0000305|PubMed:19647735	377..559		76/186 (41%)
		NMP 2. /evidence=ECO:0000269|Ref.9	406..435		14/29 (48%)
		LID 2. /evidence=ECO:0000269|Ref.9	499..509		3/10 (30%)