DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exo84 and exoc-8

DIOPT Version :9

Sequence 1:	NP_996299.1	Gene:	Exo84 / 43163	FlyBaseID:	FBgn0266668	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001021702.1	Gene:	exoc-8 / 173320	WormBaseID:	WBGene00013687	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	689	Identity:	173/689 - (25%)
Similarity:	304/689 - (44%)	Gaps:	95/689 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FSVEKYTKDLTRECVGGSD---LQQRKKEIEAYNETTAATLKQTCKKNYMEFIQTAKEISRNLES 70
            ||...|.:|..:....|.:   |:..:.|:.|.|..:..|||....:||.:||..:|||| :||.
Worm    14 FSPSDYIRDRLKGVKIGDETRKLRHLRSEMGALNHASQETLKNNVFRNYQQFIDASKEIS-HLER 77

  Fly    71 EMYQLSHILIEQRNI---LATMT-DGKTSSHLKAESLEAESTTATEDLENSHATRAVKEMVQGFN 131
            |:|||:|.||||:.:   |..|| |.|:|.|    ::.:.|||.:    .::..:.:.:.::|..
Worm    78 EIYQLTHSLIEQKQVIENLIMMTGDDKSSIH----TVSSHSTTTS----TTNPIQILMQKMEGIG 134

  Fly   132 GNLEGKTFLNE----GALIELDSNDYRPIQRVFFFLFNDVLIVCKVKHDKRLDFLTEYDPKKIAV 192
            |.|...:...:    |.:.:.|....:|:|:....|.:..||:..:....:....:......:|.
Worm   135 GILNNMSTSEKVILYGEMEQFDVETKKPVQKCMLILLSHRLIIGNINAAGKYVMESTLSLNSVAP 199

  Fly   193 INIKDLD-GVKNAINI----ITPDGSKIYQSITAAGKTEWIEKLEEAFRFDQQKKPKKGQAPQPP 252
            :|:||.: |..||..:    |.|: |:.|...:|..:|.|.::||:|.|....|.....||....
Worm   200 VNVKDRESGAANAGKVLKLLIFPE-SRCYLCESARIRTLWFDELEQAKREILHKGSLVRQATIRG 263

  Fly   253 TR--AKQQSKASTPEKETTPQSPGQPKSLEDETPE-------WLSTASEEIQTLVAQRHFEDAQE 308
            .|  .|::..|::...|..|....:.:.:.||..|       |||....|:...:|.|..:.|.|
Worm   264 KRQTVKERKAAASSAIEEKPSFLEEEEDVGDENEERNDNDISWLSELPAELDDCIAHRDLDQAVE 328

  Fly   309 LIKRTQDFLRNENRKKLPLADA-IETKVKQQELKLINVLLKELSNS---HNRNLQIALRAAKRPL 369
            ||         ...|:.|..|| |:.:::.:|..::.:|..::|..   |.     ..||.|:..
Worm   329 LI---------HEWKQCPTKDAVIDIQLQMRENTIVQLLSDDVSRPGAVHG-----GPRAMKKAR 379

  Fly   370 KILVEMGRYRQASATLLKVCAVSLRVAQREARRNNADISEL-FFCDL-TQVACDFLTAFEKQPAC 432
            .:|.::||...|:...|:..:...|.|.|:...:...||.: ..|.| .....|....|...|..
Worm   380 TLLTQLGRGTYATDVYLRRRSAMQRSAMRDVTVSEEPISYVKQLCTLYGNAVSDIANEFRSMPQY 444

  Fly   433 VSALVVWCNAELQYFASQLIKHYLTKGTSLESVAKCVERVRKPSTKLTEIGLDISYHLEGLLRTT 497
            ...::.||:.||....:.:.:|.:....::..:|...:.|......||.||:.:::.:..||...
Worm   445 YCQVLQWCSYELSTLLNLIRRHVIEVAPAIAVIAYTWKNVMHTMEDLTAIGVHLNFEVNRLLSIP 509

  Fly   498 LESLIEESKERLLDSVGR--TEESWQPYNLQTKSNLKRLLLELDVLGIDVR----AQATGDTWIN 556
            ||..::.:.|.:.|:|..  :||.|:||.|:::|.|.||:.||..:||:|.    |.....:.:|
Worm   510 LEKSLQGNFENICDAVKMRISEEKWRPYVLESESALNRLVEELSDVGINVEWAISANDESRSSLN 574

  Fly   557 LTQSTVVFIRHFLQLTEYCGCLAK-------------CETLLQSL-ELLLKELFIAQHSLKPPSD 607
            ::|:.|    ||.::..   .|:|             ||.....| ::.|:.|          :|
Worm   575 VSQNVV----HFAKVAH---TLSKDLAPLRLSPIQVLCEVYADELWKMYLQHL----------AD 622

  Fly   608 MAVDPNFVMKNKIFLVDNLLPIAIDKFRQISGRQCEGLR 646
            ...|......:..|::..:||:. ||.  :.|.:.|.:|
Worm   623 NIRDGAVFAYSTTFILTMVLPVC-DKI--LYGEEGELIR 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exo84	NP_996299.1	Vps51	4..90	CDD:285862	32/86 (37%)
		PH_RalBD_exo84	132..242	CDD:269933	27/118 (23%)
		PH	142..234	CDD:278594	23/100 (23%)
		RCSD	225..293	CDD:282963	20/76 (26%)
		Exo84_C	285..485	CDD:293136	49/212 (23%)
exoc-8	NP_001021702.1	Vps51	9..98	CDD:370074	32/84 (38%)
		PH-like	140..252	CDD:388408	25/112 (22%)
		Exo84_C	306..467	CDD:374605	41/174 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164676
Domainoid	1	1.000	55	1.000	Domainoid score	I7440
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44545
Inparanoid	1	1.050	161	1.000	Inparanoid score	I2855
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52637
OrthoDB	1	1.010	-	-		D1357584at2759
OrthoFinder	1	1.000	-	-		FOG0006078
OrthoInspector	1	1.000	-	-		oto20166
orthoMCL	1	0.900	-	-		OOG6_104892
Panther	1	1.100	-	-	LDO	PTHR21426
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2107
SonicParanoid	1	1.000	-	-		X5005
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940