DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exo84 and EXOC8

DIOPT Version :9

Sequence 1:	NP_996299.1	Gene:	Exo84 / 43163	FlyBaseID:	FBgn0266668	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_787072.2	Gene:	EXOC8 / 149371	HGNCID:	24659	Length:	725	Species:	Homo sapiens

Alignment Length:	720	Identity:	203/720 - (28%)
Similarity:	340/720 - (47%)	Gaps:	100/720 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KEFDDFNFSVEKYTKDLTRECVGGSDLQQRKKEIEAYNETTAATLKQTCKKNYMEFIQTAKEISR 66
            ::.:...|....|.|.|:::..|..|||:.::.|:|..|.||..||:...:||.:||:||:|||
Human    15 RQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRIQALAEETAQNLKRNVYQNYRQFIETAREIS- 78

  Fly    67 NLESEMYQLSHILIEQRNIL----------------ATMTDGKTS-------SHLKAES------ 102
            .||||||||||:|.||::.|                |..:.|:..       .||:.::
Human    79 YLESEMYQLSHLLTEQKSSLESIPLTLLPAAAAAGAAAASGGEEGVGGAGGRDHLRGQAGFFSTP 143

  Fly   103 -----------LEAESTTATEDLENSHATRAVKEMVQGFNGNLE--GKTFLNEGALIELDSNDYR 154
                       .|.:..|.|..||.          |:|....||  |:..:..|.|:|.|::...
Human   144 GGASRDGSGPGEEGKQRTLTTLLEK----------VEGCRHLLETPGQYLVYNGDLVEYDADHMA 198

  Fly   155 PIQRVFFFLFNDVLIVCKVKHDKR--LDFLTEYDPKKIAVINIKDLDGVKNAINIITPDGSKIYQ 217
            .:|||..||.||.|:|......:|  ..:...|....:||:|:||...:|:...::....|:|:|
Human   199 QLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYSLDGLAVVNVKDNPPMKDMFKLLMFPESRIFQ 263

  Fly   218 SITAAGKTEWIEKLEEAFRFDQQKKPKKGQ---APQPPTRAKQQSKASTPEKETTPQSPGQPKSL 279
            :..|..|.||:|.||:..|...:|:.::.:   ||:.|.:.  .|||:.|.::...:.|..|:..
Human   264 AENAKIKREWLEVLEDTKRALSEKRRREQEEAAAPRGPPQV--TSKATNPFEDDEEEEPAVPEVE 326

  Fly   280 E---DETPEWLSTASEEIQTLVAQRHFEDAQELIKRTQDFLRNENRKKLPLADAIETKVKQQELK 341
            |   |.:.||:....|::...:|||.||.|.:|:.:...:|  |::...|....:..||:::..:
Human   327 EEKVDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYL--EDKPSPPPVKELRAKVEERVRQ 389

  Fly   342 LINVLLKELSNSHNRNLQIALRAAKRPLKILVEMGRYRQASATLLKVCAVSLRVAQREARRNNA- 405
            |..||:.||  |.:|:|:...:|.:|.:..|:.:|:..:|....|:..|.::..|.|:.|...|
Human   390 LTEVLVFEL--SPDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGAT 452

  Fly   406 -----DISELFFCDLTQVACDFLTAFE-KQPACVSALVVWCNAELQYFASQLIKHYLTKGTSLES 464
                 .:..:||..|.:.|.:|...|. ....|.||.|||..:.:..|.....|.......||.:
Human   453 LLYIHKLCHVFFTSLLETAREFEIDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLST 517

  Fly   465 VAKCVERVRKPSTKLTEIGLDISY--------HLEGLLRTTLESLIEESKERLLDSVGRTEESWQ 521
            .|:||:..::...:|.:||||:::        .::|.|.:..|.:||.:|.|      .:||.|:
Human   518 AAECVKVAKEHCQQLGDIGLDLTFIIHALLVKDIQGALHSYKEIIIEATKHR------NSEEMWR 576

  Fly   522 PYNLQTKSNLKRLLLELDVLGIDVRAQATG-DTWINLTQSTVVFIRHFLQLTEYCGCLAKCETLL 585
            ..||.|...|.:|..|:...|:....|.|| |.|:||:.:.|.|.:..:...|....|...|..:
Human   577 RMNLMTPEALGKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHM 641

  Fly   586 QSLELLLKELFIA-QH---SLKPPSDMAVDPN---FVMKNKIFLVDNLLPIAIDKFRQISGRQCE 643
            ..||.|::.:.:| ||   ||:    ...||.   |:.:|..||.:.:||:...:|.:..|:..:
Human   642 VLLESLVEIILVAVQHVDYSLR----CEQDPEKKAFIRQNASFLYETVLPVVEKRFEEGVGKPAK 702

  Fly   644 GLREL 648
            .|::|
Human   703 QLQDL 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exo84	NP_996299.1	Vps51	4..90	CDD:285862	39/101 (39%)
		PH_RalBD_exo84	132..242	CDD:269933	35/113 (31%)
		PH	142..234	CDD:278594	31/93 (33%)
		RCSD	225..293	CDD:282963	20/73 (27%)
		Exo84_C	285..485	CDD:293136	56/206 (27%)
EXOC8	NP_787072.2	Vps51	17..101	CDD:400855	38/84 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..159		1/21 (5%)
		PH_RalBD_exo84	176..288	CDD:269933	35/111 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..328		10/44 (23%)
		Exo84_C	335..540	CDD:406833	58/208 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156697
Domainoid	1	1.000	85	1.000	Domainoid score	I8183
eggNOG	1	0.900	-	-		E1_KOG2215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44545
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3292
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52637
OrthoDB	1	1.010	-	-		D1357584at2759
OrthoFinder	1	1.000	-	-		FOG0006078
OrthoInspector	1	1.000	-	-		oto91287
orthoMCL	1	0.900	-	-		OOG6_104892
Panther	1	1.100	-	-	LDO	PTHR21426
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2107
SonicParanoid	1	1.000	-	-		X5005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840