Protein Alignment Exo84 and Exoc8

DIOPT Version :10

• Sequence 1: NP_996299.1
• Gene: Exo84 / 43163
• FlyBaseID: FBgn0266668
• Length: 672
• Species: Drosophila melanogaster
• Sequence 2: NP_932771.1
• Gene: Exoc8 / 102058
• MGIID: 2142527
• Length: 716
• Species: Mus musculus
• Alignment Length: 710
• Identity: 204/710 - (28%)
• Similarity: 338/710 - (47%)
• Gaps: 85/710 - (11%)

  Fly     2 KEFDDFNFSVEKYTKDLTRECVGGSDLQQRKKEIEAYNETTAATLKQTCKKNYMEFIQTAKEISR 66
            ::.:...|....|.|.|:::..|..|||:.::.::|..|.||..||:...:||.:||:||:|||
Mouse    11 RQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRVQALAEETAQNLKRNVYQNYRQFIETAREIS- 74

  Fly    67 NLESEMYQLSHILIEQRN--------ILATMTDGKTSSHLKAESLEAE----------------- 106
            .||||||||||:|.||::        :|.....|.::....|.:...|
Mouse    75 YLESEMYQLSHLLTEQKSSLESIPLALLPAAAAGASAGEDTAGAGPRERGAVQAGFLPGPAGVPR 139

  Fly   107 --STTATEDLENSHATRAVKEMVQGFNGNLE--GKTFLNEGALIELDSNDYRPIQRVFFFLFNDV 167
              |.|..|..:.:..|  :.|.|:|....||  |:..:..|.|:|.|::....:|||..||.||.
Mouse   140 EGSGTGEEGKQRTLTT--LLEKVEGCRDLLETPGQYLVYNGDLVEYDADHMAQLQRVHGFLMNDC 202

  Fly   168 LIVCKVKHDKR--LDFLTEYDPKKIAVINIKDLDGVKNAINIITPDGSKIYQSITAAGKTEWIEK 230
            |:|......:|  ..:...|...::||:|:||...:|:...::....|:|:|:..|..|.||:|.
Mouse   203 LLVATWLPQRRGMYRYNALYPLDRLAVVNVKDNPPMKDMFKLLMFPESRIFQAENAKIKREWLEV 267

  Fly   231 LEEAFRFDQQKKPKKGQ------APQPPTRAKQQSKASTPEKETTPQSPGQPKSLE---DETPEW 286
            |||..|....|:.::.:      ||.|.|     ||.|.|.::...:....|::.|   |.:.||
Mouse   268 LEETKRALSDKRRREQEEAAAPRAPPPVT-----SKGSNPFEDEDDEELATPEAEEEKVDLSMEW 327

  Fly   287 LSTASEEIQTLVAQRHFEDAQELIKRTQDFLRNENRKKLPLADAIETKVKQQELKLINVLLKELS 351
            :....|::...:|||.||.|.:|:.:...:|  |::...|....:..||.::..:|..||:.||
Mouse   328 IQELPEDLDVCIAQRDFEGAVDLLDKLNHYL--EDKPSPPPVKELRAKVDERVRQLTEVLVFEL- 389

  Fly   352 NSHNRNLQIALRAAKRPLKILVEMGRYRQASATLLKVCAVSLRVAQREARRNNA------DISEL 410
             |.:|:|:...:|.:|.:..|:.:|:..:|....|:..|.::..|.|:.|...|      .:..:
Mouse   390 -SPDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHV 453

  Fly   411 FFCDLTQVACDFLTAFE-KQPACVSALVVWCNAELQYFASQLIKHYLTKGTSLESVAKCVERVRK 474
            ||..|.:.|.:|.|.|. ....|.||.|||..:.:..|.....|.......||.:.|:||:..::
Mouse   454 FFTSLLETAREFETDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKE 518

  Fly   475 PSTKLTEIGLDISY--------HLEGLLRTTLESLIEESKERLLDSVGRTEESWQPYNLQTKSNL 531
            ...:|.|||||:::        .::|.|.:..|.:||.:|.|      .:||.|:..||.|...|
Mouse   519 HCQQLGEIGLDLTFIIHALLVKDIQGALHSYKEIIIEATKHR------NSEEMWRRMNLMTPEAL 577

  Fly   532 KRLLLELDVLGIDVRAQATG-DTWINLTQSTVVFIRHFLQLTEYCGCLAKCETLLQSLELLLKEL 595
            .:|..|:...|:....|.|| |.|:||:.:.|.|.:..:...|....|...|..:..||.|::.:
Mouse   578 GKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEII 642

  Fly   596 FIA-QH---SLKPPSDMAVDPN---FVMKNKIFLVDNLLPIAIDKFRQISGRQCEGLREL 648
            .:| ||   ||:    ...||.   |:.:|..||.:.:||:...:|.:..|:..:.|::|
Mouse   643 LVAVQHVDYSLR----CEQDPEKKAFIRQNASFLYETVLPVVERRFEEGVGKPAKQLQDL 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exo84	NP_996299.1	Vps51	4..90	CDD:462568	37/93 (40%)
		PH_RalBD_exo84	132..242	CDD:269933	36/113 (32%)
		Exo84_C	285..485	CDD:465161	58/206 (28%)
Exoc8	NP_932771.1	Vps51	13..97	CDD:462568	36/84 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..150		3/20 (15%)
		PH_RalBD_exo84	167..279	CDD:269933	36/111 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	275..319		10/48 (21%)
		Exo84_C	326..531	CDD:465161	60/208 (29%)