DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exo84 and Exoc8

DIOPT Version :9

Sequence 1:	NP_996299.1	Gene:	Exo84 / 43163	FlyBaseID:	FBgn0266668	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_932771.1	Gene:	Exoc8 / 102058	MGIID:	2142527	Length:	716	Species:	Mus musculus

Alignment Length:	710	Identity:	204/710 - (28%)
Similarity:	338/710 - (47%)	Gaps:	85/710 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KEFDDFNFSVEKYTKDLTRECVGGSDLQQRKKEIEAYNETTAATLKQTCKKNYMEFIQTAKEISR 66
            ::.:...|....|.|.|:::..|..|||:.::.::|..|.||..||:...:||.:||:||:|||
Mouse    11 RQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRVQALAEETAQNLKRNVYQNYRQFIETAREIS- 74

  Fly    67 NLESEMYQLSHILIEQRN--------ILATMTDGKTSSHLKAESLEAE----------------- 106
            .||||||||||:|.||::        :|.....|.::....|.:...|
Mouse    75 YLESEMYQLSHLLTEQKSSLESIPLALLPAAAAGASAGEDTAGAGPRERGAVQAGFLPGPAGVPR 139

  Fly   107 --STTATEDLENSHATRAVKEMVQGFNGNLE--GKTFLNEGALIELDSNDYRPIQRVFFFLFNDV 167
              |.|..|..:.:..|  :.|.|:|....||  |:..:..|.|:|.|::....:|||..||.||.
Mouse   140 EGSGTGEEGKQRTLTT--LLEKVEGCRDLLETPGQYLVYNGDLVEYDADHMAQLQRVHGFLMNDC 202

  Fly   168 LIVCKVKHDKR--LDFLTEYDPKKIAVINIKDLDGVKNAINIITPDGSKIYQSITAAGKTEWIEK 230
            |:|......:|  ..:...|...::||:|:||...:|:...::....|:|:|:..|..|.||:|.
Mouse   203 LLVATWLPQRRGMYRYNALYPLDRLAVVNVKDNPPMKDMFKLLMFPESRIFQAENAKIKREWLEV 267

  Fly   231 LEEAFRFDQQKKPKKGQ------APQPPTRAKQQSKASTPEKETTPQSPGQPKSLE---DETPEW 286
            |||..|....|:.::.:      ||.|.|     ||.|.|.::...:....|::.|   |.:.||
Mouse   268 LEETKRALSDKRRREQEEAAAPRAPPPVT-----SKGSNPFEDEDDEELATPEAEEEKVDLSMEW 327

  Fly   287 LSTASEEIQTLVAQRHFEDAQELIKRTQDFLRNENRKKLPLADAIETKVKQQELKLINVLLKELS 351
            :....|::...:|||.||.|.:|:.:...:|  |::...|....:..||.::..:|..||:.||
Mouse   328 IQELPEDLDVCIAQRDFEGAVDLLDKLNHYL--EDKPSPPPVKELRAKVDERVRQLTEVLVFEL- 389

  Fly   352 NSHNRNLQIALRAAKRPLKILVEMGRYRQASATLLKVCAVSLRVAQREARRNNA------DISEL 410
             |.:|:|:...:|.:|.:..|:.:|:..:|....|:..|.::..|.|:.|...|      .:..:
Mouse   390 -SPDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHV 453

  Fly   411 FFCDLTQVACDFLTAFE-KQPACVSALVVWCNAELQYFASQLIKHYLTKGTSLESVAKCVERVRK 474
            ||..|.:.|.:|.|.|. ....|.||.|||..:.:..|.....|.......||.:.|:||:..::
Mouse   454 FFTSLLETAREFETDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKE 518

  Fly   475 PSTKLTEIGLDISY--------HLEGLLRTTLESLIEESKERLLDSVGRTEESWQPYNLQTKSNL 531
            ...:|.|||||:::        .::|.|.:..|.:||.:|.|      .:||.|:..||.|...|
Mouse   519 HCQQLGEIGLDLTFIIHALLVKDIQGALHSYKEIIIEATKHR------NSEEMWRRMNLMTPEAL 577

  Fly   532 KRLLLELDVLGIDVRAQATG-DTWINLTQSTVVFIRHFLQLTEYCGCLAKCETLLQSLELLLKEL 595
            .:|..|:...|:....|.|| |.|:||:.:.|.|.:..:...|....|...|..:..||.|::.:
Mouse   578 GKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEII 642

  Fly   596 FIA-QH---SLKPPSDMAVDPN---FVMKNKIFLVDNLLPIAIDKFRQISGRQCEGLREL 648
            .:| ||   ||:    ...||.   |:.:|..||.:.:||:...:|.:..|:..:.|::|
Mouse   643 LVAVQHVDYSLR----CEQDPEKKAFIRQNASFLYETVLPVVERRFEEGVGKPAKQLQDL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exo84	NP_996299.1	Vps51	4..90	CDD:285862	37/93 (40%)
		PH_RalBD_exo84	132..242	CDD:269933	36/113 (32%)
		PH	142..234	CDD:278594	31/93 (33%)
		RCSD	225..293	CDD:282963	21/76 (28%)
		Exo84_C	285..485	CDD:293136	58/206 (28%)
Exoc8	NP_932771.1	Vps51	13..97	CDD:285862	36/84 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..150		3/20 (15%)
		PH_RalBD_exo84	167..279	CDD:269933	36/111 (32%)
		PH	174..273	CDD:278594	32/98 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..319		10/48 (21%)
		Exo84_C	326..531	CDD:293136	60/208 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847105
Domainoid	1	1.000	87	1.000	Domainoid score	I8034
eggNOG	1	0.900	-	-		E1_KOG2215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44545
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3239
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52637
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006078
OrthoInspector	1	1.000	-	-		oto94866
orthoMCL	1	0.900	-	-		OOG6_104892
Panther	1	1.100	-	-	LDO	PTHR21426
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2107
SonicParanoid	1	1.000	-	-		X5005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790