DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and Strn4

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_598550.2	Gene:	Strn4 / 97387	MGIID:	2142346	Length:	760	Species:	Mus musculus

Alignment Length:	702	Identity:	146/702 - (20%)
Similarity:	227/702 - (32%)	Gaps:	263/702 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSPVRHPAAGG---PPPQGPIKFTIADTLERIKEEF-NF-------------LQAQYHSIKLECE 50
            |.||.....||   .|..||...::...|..|:.|: .|             ||||...::.|.:
Mouse    41 PGPVGKGGGGGGSPGPTAGPEPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERK 105

  Fly    51 KLSNEKTEMQRHYVM-----------YYEMSYGLNVEM-HKQTEIAKRLN-------TLINQLLP 96
            ...|.||::.|...|           |:::.:|.::.. .|:|:::::::       ||.|.  |
Mouse   106 GQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKTDLSEQVSNGPVESVTLENS--P 168

  Fly    97 FLQADHQQQVLQAVE-----------RAKQVTMQELNLIIGHQ-QQHGIQQLLQQIHAQQVPGGP 149
            .:..:.:|.:.|.:|           |:|:|     ..::|.. :.:|.        .:.|.|.|
Mouse   169 LVWKEGRQLLRQYLEEVGYTDTILDMRSKRV-----RSLLGRSLELNGA--------GEPVEGAP 220

  Fly   150 ---PQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIK--PTGLEGPAAAEERLRNSV--- 206
               |.| |.|:             |.:.||.|..|.   .||  ..|.:|    :|||..||
Mouse   221 RASPGP-GGLS-------------GGESLLVKQIEE---QIKRNAAGKDG----KERLGGSVLEQ 264

  Fly   207 -----SPADREKYRTRSPLDIENDSKRRKDEKLQ----------EDEGEKSDQDLVVDVANEMES 256
                 :..|.:     |..|.|.||.:.|.::::          |||.|:.|.:   |..||.:.
Mouse   265 IPFLQNCEDED-----SDEDDELDSVQHKKQRVRLPSKALVPEMEDEDEEDDSE---DAINEFDF 321

  Fly   257 HSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDMEKPGTPG 321
                                        ..||...|..|.....:|..:...|:::.::..|..
Mouse   322 ----------------------------LGSGEDGEGSPDPRRCTSEGNPHELESRRVKLQGIL- 357

  Fly   322 AKARTPTPNAAAPAPGVNPKQMMPQGPPPAGYPGAPYQRPADPYQRPPSDPAYGRPPPMPYDPHA 386
            |..|        ...|:.||..:|                      ||     |.|.|.|:
Mouse   358 ADLR--------DVDGLPPKVTVP----------------------PP-----GTPQPRPH---- 383

  Fly   387 HVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVV---- 447
                                      |||.   .|..|..:          ::|:..|||.
Mouse   384 --------------------------EGSF---GFSSDVFI----------MDTIGGGEVSLGDL 409

  Fly   448 --CAVTISNPTKYVYTGGKGCV-KVWDISQPGNKNPVSQLDCLQRDNY--IRSVKLLPDGRTLIV 507
              ..||..|......:..|... |.|        ||...|    |.:|  |||:........|:.
Mouse   410 ADLTVTNDNDLSCDLSDSKDAFKKTW--------NPKFTL----RSHYDGIRSLAFHHSQSALLT 462

  Fly   508 GGEASNLSIWDLASPTPRIKAELTSAAP---------ACYALAISPDSKVCFSCCSDGNIAVW-- 561
            ..|...|.:|:|.......|.......|         ...|:.:..:|:.|:|..:|..|..|
Mouse   463 ASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVTMGSNSEYCYSGGADARIHSWKI 527

  Fly   562 -DLHNE--------ILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWD 604
             ||:.:        :|....:||.|....:..||...||.:...|.|||.||
Mouse   528 PDLNMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	33/159 (21%)
		WD40	442..727	CDD:238121	47/192 (24%)
		WD40 repeat	447..486	CDD:293791	9/45 (20%)
		WD40 repeat	494..532	CDD:293791	8/37 (22%)
		WD40 repeat	537..573	CDD:293791	10/46 (22%)
		WD40 repeat	580..615	CDD:293791	10/25 (40%)
		WD40 repeat	620..653	CDD:293791
		WD40 repeat	661..695	CDD:293791
		WD40 repeat	702..726	CDD:293791
Strn4	NP_598550.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65		8/23 (35%)
		Striatin	64..189	CDD:285445	25/126 (20%)
		Caveolin-binding. /evidence=ECO:0000255	71..79		2/7 (29%)
		Calmodulin-binding. /evidence=ECO:0000255	165..182		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..233		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..346		20/109 (18%)
		WD40	423..>753	CDD:225201	41/169 (24%)
		WD40	437..759	CDD:238121	37/147 (25%)
		WD 1	443..482		9/38 (24%)
		WD40 repeat	450..496	CDD:293791	8/45 (18%)
		WD 2	496..535		9/38 (24%)
		WD40 repeat	502..549	CDD:293791	10/46 (22%)
		WD 3	549..588		13/31 (42%)
		WD40 repeat	554..594	CDD:293791	10/26 (38%)
		WD 4	595..635
		WD40 repeat	601..637	CDD:293791
		WD 5	642..681
		WD40 repeat	647..683	CDD:293791
		WD 6	684..723
		WD40 repeat	689..728	CDD:293791
		WD 7	730..759
		WD40 repeat	735..759	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910