DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and PRPF4

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_004688.2 Gene:PRPF4 / 9128 HGNCID:17349 Length:522 Species:Homo sapiens


Alignment Length:236 Identity:65/236 - (27%)
Similarity:101/236 - (42%) Gaps:16/236 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   495 SVKLLPDGRTLIVGGEASNLSIWDLAS--PTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGN 557
            :|.|.|....|.......::.:|.|.|  |...|:......|...:    .|..:...:.|.|.:
Human   286 TVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMW----HPSGRFLGTTCYDRS 346

  Fly   558 IAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGR---QLQQHDFSSQ 619
            ..:|||..:..:...:||:.|...|....|||...|||||...|.||||.||   .|:.|  ..:
Human   347 WRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH--LKE 409

  Fly   620 IFSLGYCPTGDWLAVGMENSHVEVLH-ASKPDKYQLHLHESCVLSLRFAACGKWFVSTGK-DNLL 682
            |:.:.:.|.|..:|.|..::..:|.. ..:...|.:..|::.|..::|......|:.||. ||..
Human   410 IYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 474

  Fly   683 NAWRTPYGASIFQ--SKETSSVLSCDISTDDKYIVTGSGDK 721
            ..|..| |.|..:  :.....|:..|||:|.:.|.|.|.|:
Human   475 KIWTHP-GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 65/236 (28%)
WD40 repeat 447..486 CDD:293791
WD40 repeat 494..532 CDD:293791 9/38 (24%)
WD40 repeat 537..573 CDD:293791 6/35 (17%)
WD40 repeat 580..615 CDD:293791 17/37 (46%)
WD40 repeat 620..653 CDD:293791 6/33 (18%)
WD40 repeat 661..695 CDD:293791 11/34 (32%)
WD40 repeat 702..726 CDD:293791 9/20 (45%)
PRPF4NP_004688.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SFM 103..141 CDD:128776
WD 1 229..268
WD40 233..519 CDD:238121 65/236 (28%)
WD40 repeat 234..271 CDD:293791
WD 2 271..318 8/31 (26%)
WD40 repeat 285..321 CDD:293791 9/34 (26%)
WD 3 321..360 7/42 (17%)
WD40 repeat 326..362 CDD:293791 7/39 (18%)
WD 4 363..402 19/38 (50%)
WD40 repeat 369..404 CDD:293791 16/34 (47%)
WD 5 405..444 7/40 (18%)
WD40 repeat 410..444 CDD:293791 6/33 (18%)
WD 6 447..487 12/40 (30%)
WD40 repeat 452..489 CDD:293791 11/37 (30%)
WD 7 490..521 9/25 (36%)
WD40 repeat 495..519 CDD:293791 9/20 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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