DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and PFS2

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_014082.1	Gene:	PFS2 / 855399	SGDID:	S000005261	Length:	465	Species:	Saccharomyces cerevisiae

Alignment Length:	397	Identity:	77/397 - (19%)
Similarity:	129/397 - (32%)	Gaps:	149/397 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 PYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGE 445
            ||....:.|.:|:  |:.:...:.:|:..:          .||:|..|     ..|.||.
Yeast    38 PYINLYYNRRHGL--PNLVVEPETSYTIDI----------MPPNAYRG-----RDRVINL----- 80

  Fly   446 VVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGE 510
                     |:|:.:.               :.|.|..:        |.:::..|:||.|:|...
Yeast    81 ---------PSKFTHL---------------SSNKVKHV--------IPAIQWTPEGRRLVVATY 113

  Fly   511 ASNLSIWDLASPTPRIKAELTSAA-----------------------------------PACYAL 540
            :...|:|:.:|.|.....:...:|                                   .|.:..
Yeast   114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTE 178

  Fly   541 AI------SPDSKVCFSCCSDGNI-AVWDLHNEILVRQFQG-HTDGASCIDISPDGSRLWTGGLD 597
            :|      |.|||  |..|||.|| .:|:..|....|...| |.|..|| |..|:...:.:...|
Yeast   179 SIRDMAFSSNDSK--FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMGLIASASKD 240

  Fly   598 NTVRSWDLREGRQLQ-----QH--------------------DFSSQIFSLGY------C----- 626
            |.|:.||.|.|..:.     :|                    |.|.::|.:.|      |
Yeast   241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305

  Fly   627 --PTGDWLAVGMEN----------SHVEVL-HASKPDKYQLHLHESCVLSLRFAACGKWFVSTGK 678
              .|.:|..:....          .|.::| :.::|.....:.|:.|:.||.:...|..|.:..|
Yeast   306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAK 370

  Fly   679 DNLLNAW 685
            |..:..|
Yeast   371 DRTIRFW 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	64/336 (19%)
		WD40 repeat	447..486	CDD:293791	4/38 (11%)
		WD40 repeat	494..532	CDD:293791	9/37 (24%)
		WD40 repeat	537..573	CDD:293791	14/42 (33%)
		WD40 repeat	580..615	CDD:293791	12/59 (20%)
		WD40 repeat	620..653	CDD:293791	8/56 (14%)
		WD40 repeat	661..695	CDD:293791	7/25 (28%)
		WD40 repeat	702..726	CDD:293791
PFS2	NP_014082.1	WD40	93..377	CDD:238121	59/294 (20%)
		WD40 repeat	98..133	CDD:293791	9/34 (26%)
		WD40 repeat	139..175	CDD:293791	0/35 (0%)
		WD40 repeat	180..216	CDD:293791	14/37 (38%)
		WD40 repeat	223..257	CDD:293791	11/34 (32%)
		WD40 repeat	264..299	CDD:293791	4/34 (12%)
		WD40 repeat	307..346	CDD:293791	5/38 (13%)
		WD40 repeat	353..377	CDD:293791	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910