DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and CAF4

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_012962.3	Gene:	CAF4 / 853908	SGDID:	S000001744	Length:	643	Species:	Saccharomyces cerevisiae

Alignment Length:	652	Identity:	132/652 - (20%)
Similarity:	206/652 - (31%)	Gaps:	273/652 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 PTGLEGPAAA----EERLR----NSVSPADREKY------------RTRSPLD-----------I 222
            |:..||..|.    ::||.    :..:.:|:|||            :|.|.:|           :
Yeast   108 PSLFEGFKATVSIIQQRLLLDNVDGATNSDKEKYVQLPDINTGFVNKTYSRIDLTHLLEDVETNV 172

  Fly   223 ENDSKRRKDEKLQEDEGEKSDQDLVVDVANEMESH------------SPRPNGEHVSMEVRDRES 275
            ||.|   .::.|:.||..:.|     .:.||:||.            |...|.|:....::||.:
Yeast   173 ENLS---INKTLEMDELTRLD-----SMINELESRKLKILERVKHIDSKSTNLENDVTLIKDRIN 229

  Fly   276 LNGE-RLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDMEKPGTPGAKARTPTPNAAAPAPGVN 339
            ...| .||......::::....||..:||                     .|....|.:....|.
Yeast   230 FIEEYNLEADREQSLRKQMEEERSSEASS---------------------FTQNEEAISSLCDVE 273

  Fly   340 PKQMMPQGPPPAGYPGAPYQRPADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKP 404
            .|.                .|..|.|:             ||:: .:|.:...|   .:.|..:.
Yeast   274 SKD----------------TRLKDFYK-------------MPHE-KSHDKNRQI---ISETYSRN 305

  Fly   405 AYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGC--- 466
            ..:|.|.                   || |.      .||..:.|:....|      .|..|
Yeast   306 TTAFRMT-------------------IP-HG------EHGNSITALDFDTP------WGTLCSSS 338

  Fly   467 -----VKVWDISQ-------PGNKNPVSQLDCLQRD--NYIRSVKLLPDGRTLIVGGEASNLSIW 517
                 |||||::.       ||:   ::.::|:|.|  ||          ..||.|.:.:.|.:|
Yeast   339 YQDRIVKVWDLNHGIQVGELPGH---LATVNCMQIDKKNY----------NMLITGSKDATLKLW 390

  Fly   518 DL---------ASP---------TPRI------KAELTSAA------------------------ 534
            ||         .||         ||.|      |.|:|:.:
Yeast   391 DLNLSREIYLDHSPLKEKTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHWDLTTGK 455

  Fly   535 ------------------PA---------------------CYALAISPDSKVCFSCCSDGNIAV 560
                              ||                     ||..|::..:|       ||.:.:
Yeast   456 CIQQLDLIFTPTHSDIKMPARSLNNGACLLGTEAPMIGALQCYNSALATGTK-------DGIVRL 513

  Fly   561 WDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGY 625
            |||.....||..:|||||.:.:..  |..:|.||.:||:||.||||....|....:...:.||.:
Yeast   514 WDLRVGKPVRLLEGHTDGITSLKF--DSEKLVTGSMDNSVRIWDLRTSSILDVIAYDLPVSSLDF 576

  Fly   626 CPTGDWLAVGMENSHVEVLHASKPDKYQL----HLHESCVLSLRFAAC---GKWFVSTGKDNLLN 683
              .|..:.||.....|.|.:..:.:.:..    |..:...||.|.|..   ..:.::...|..:|
Yeast   577 --DGKLITVGANEGGVNVFNMERDEHWMTPEPPHSLDGDELSRRIAIVKYKDGFLINGHNDGDIN 639

  Fly   684 AW 685
            .|
Yeast   640 VW 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	79/355 (22%)
		WD40 repeat	447..486	CDD:293791	11/53 (21%)
		WD40 repeat	494..532	CDD:293791	14/61 (23%)
		WD40 repeat	537..573	CDD:293791	11/35 (31%)
		WD40 repeat	580..615	CDD:293791	13/34 (38%)
		WD40 repeat	620..653	CDD:293791	7/32 (22%)
		WD40 repeat	661..695	CDD:293791	7/28 (25%)
		WD40 repeat	702..726	CDD:293791
CAF4	NP_012962.3	Caf4	65..124	CDD:402971	4/15 (27%)
		WD40	318..641	CDD:238121	78/352 (22%)
		WD40 repeat	322..360	CDD:293791	9/43 (21%)
		WD40 repeat	366..422	CDD:293791	17/65 (26%)
		WD40 repeat	427..461	CDD:293791	1/33 (3%)
		WD40 repeat	472..526	CDD:293791	13/60 (22%)
		WD40 repeat	532..563	CDD:293791	12/32 (38%)
		WD40 repeat	571..611	CDD:293791	8/41 (20%)
		WD40 repeat	617..641	CDD:293791	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910