DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and TUP1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_010007.1	Gene:	TUP1 / 850445	SGDID:	S000000680	Length:	713	Species:	Saccharomyces cerevisiae

Alignment Length:	756	Identity:	164/756 - (21%)
Similarity:	273/756 - (36%)	Gaps:	177/756 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DTLERIKEEFNFLQAQYHSIKLECE-----KLSNEKTEMQRHYVMYYEMSYGLNVEMHKQTEIAK 85
            :.|:.|::||..:..:.::.:|:.:     |::.:..|||:.....||:............|..|
Yeast    14 ELLDAIRQEFLQVSQEANTYRLQNQKDYDFKMNQQLAEMQQIRNTVYELELTHRKMKDAYEEEIK 78

  Fly    86 RLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQHGIQQLLQQIHAQQ----VP 146
            .|.      |...|.|||...|...::.:|...|::       ||| :||..||:.|..    |.
Yeast    79 HLK------LGLEQRDHQIASLTVQQQRQQQQQQQV-------QQH-LQQQQQQLAAASASVPVA 129

  Fly   147 GGPPQPMGA-LNPFGALGATMGLPHGPQGLLNKPPEHHRPDIKPTGLEGPAAAEERLRNSVSPAD 210
            ..||....| ..|  |...|.|.|..      .|.:..||::  .|.:.|.
Yeast   130 QQPPATTSATATP--AANTTTGSPSA------FPVQASRPNL--VGSQLPT-------------- 170

  Fly   211 REKYRTRSPLDIENDSKRRKDEKLQEDEGEKSDQDLVVDVANEMESHSPRPNGEHVSMEVRDRES 275
                 |..|:...|..::...::||:               .:::...|.|   .||:......:
Yeast   171 -----TTLPVVSSNAQQQLPQQQLQQ---------------QQLQQQQPPP---QVSVAPLSNTA 212

  Fly   276 LNGERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDMEKPGTPGAKARTPTPNAAAPAPGVNP 340
            :||....|.:::....:.|.|....:...:..:.|..|     |..|...|.|   .|....:.|
Yeast   213 INGSPTSKETTTLPSVKAPESTLKETEPENNNTSKIND-----TGSATTATTT---TATETEIKP 269

  Fly   341 KQMMPQGPPPAG----YPGAPYQRPADPYQRPPSDPAYGRP-PPMPYDPHAHVRTNGIPHPSALT 400
            |:   :...||.    :...||.:.|:          :.:| ||...|    :.:..:  |.||.
Yeast   270 KE---EDATPASLHQDHYLVPYNQRAN----------HSKPIPPFLLD----LDSQSV--PDALK 315

  Fly   401 GGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQIN-----TLSHGEVVCAVTISNPTKYVY 460
            .....|....|                    |...|:|:     :|.|..|||.|..||..:|:.
Yeast   316 KQTNDYYILYN--------------------PALPREIDVELHKSLDHTSVVCCVKFSNDGEYLA 360

  Fly   461 TGGKGCVKVWDISQPGNKNPVSQL-DCLQRDNYIRSV-----KLLPDGRTLIVGGEASNLSIWDL 519
            |   ||.|...:.:..:.:.|::| |....:|:..|:     ....|..|:      :..:...:
Yeast   361 T---GCNKTTQVYRVSDGSLVARLSDDSAANNHRNSITENNTTTSTDNNTM------TTTTTTTI 416

  Fly   520 ASPTPRIKAEL--------TSAAPA----CYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQF 572
            .:......|||        ||::|:    ..::..|||.|...:...|..|.:||:.|..:|...
Yeast   417 TTTAMTSAAELAKDVENLNTSSSPSSDLYIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMIL 481

  Fly   573 QGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCP-TGDWLAVGM 636
            |||......:|..|.|.:|.:|..|.|||.||||.|:..........:.::...| .|.::|.|.
Yeast   482 QGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGKYIAAGS 546

  Fly   637 ENSHVEV--------LHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASI 693
            .:..|.|        :.....:......|:..|.|:.|...|:..||...|..:..|......:.
Yeast   547 LDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNK 611

  Fly   694 FQSKETSS-------------VLSCDISTDDKYIVTGSGDK 721
            ..||..:|             |||...:.:|:||::||.|:
Yeast   612 SDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDR 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	22/102 (22%)
		WD40	442..727	CDD:238121	79/320 (25%)
		WD40 repeat	447..486	CDD:293791	12/39 (31%)
		WD40 repeat	494..532	CDD:293791	6/50 (12%)
		WD40 repeat	537..573	CDD:293791	10/35 (29%)
		WD40 repeat	580..615	CDD:293791	14/34 (41%)
		WD40 repeat	620..653	CDD:293791	6/41 (15%)
		WD40 repeat	661..695	CDD:293791	8/33 (24%)
		WD40 repeat	702..726	CDD:293791	9/20 (45%)
TUP1	NP_010007.1	Tup_N	11..88	CDD:400755	16/79 (20%)
		WD40	343..706	CDD:238121	79/319 (25%)
		WD40 repeat	347..383	CDD:293791	12/38 (32%)
		WD40 repeat	394..438	CDD:293791	6/49 (12%)
		WD40 repeat	447..483	CDD:293791	10/35 (29%)
		WD40 repeat	488..523	CDD:293791	14/34 (41%)
		WD40 repeat	530..566	CDD:293791	6/35 (17%)
		WD40 repeat	579..627	CDD:293791	11/47 (23%)
		WD40 repeat	633..669	CDD:293791	9/20 (45%)
		WD40 repeat	675..705	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910