DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and Tle3

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006243273.1	Gene:	Tle3 / 84424	RGDID:	620292	Length:	782	Species:	Rattus norvegicus

Alignment Length:	818	Identity:	486/818 - (59%)
Similarity:	562/818 - (68%)	Gaps:	124/818 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |||.. ||||...|...| .|||:|::.:|||:||.||||||||:|:|.:||:||||||||||||
  Rat     1 MYPQG-RHPAPHQPGQPG-FKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVM 63

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQ 130
            |||||||||:||||||||||||||::.|::|||..:|||||.|||||||||||.|||.|||.:..
  Rat    64 YYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGL 128

  Fly   131 HGI---QQLLQQIHAQQVPGGPP----------QPMG---------ALNPFGALGATMGLPHGPQ 173
            ..:   ||.||..|......|||          ||.|         .|...||||:...|
  Rat   129 PNLPLTQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHL----- 188

  Fly   174 GLLNKPPEHHRPDIKPTGLEGPAAAEERLRNSVSPAD--REKYRTRSPLDIENDSKRRKDEKLQ- 235
             .:.....||..|.:        ..|....|||||::  |...:.|...|...::|:||.|:..
  Rat   189 -AVKDEKNHHELDHR--------ERESSTNNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDS 244

  Fly   236 ----EDEGEKSDQDLVVDVANE-------MESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGI 289
                :.:|:||| ||||||:||       ..:|||..||                 |:|  :.|:
  Rat   245 LSRYDSDGDKSD-DLVVDVSNEDPATPRVSPAHSPPENG-----------------LDK--ARGL 289

  Fly   290 KQERPPSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPGVNPK---QMMPQGP 348
            |::.|.|.:..:||.||||.||||:   :|..|||.|:.||||...||.||.:..   :.||..|
  Rat   290 KKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKP 354

  Fly   349 P---PAGYPGAPYQRP---ADPYQRP-------------------------PSD---------PA 373
            |   |.|...:..:.|   ...|..|                         ||.         .|
  Rat   355 PGMDPIGIMASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGLHNIPSQMSAAAAAAAAA 419

  Fly   374 YGRPP-----PMPYDPHAHVRTNGIPHP-SALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIP 432
            |||.|     .:.:|||..:|..|:|.. :::.|||||||||::.:|.:||||||.|||.|.|||
  Rat   420 YGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIP 484

  Fly   433 RHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVK 497
            ||||||||||||||||||||||||::||||||||||:|||||||:|:|:||||||.|||||||.|
  Rat   485 RHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCK 549

  Fly   498 LLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWD 562
            |||||||||||||||.|:|||||||||||||||||:||||||||||||:||||||||||||||||
  Rat   550 LLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWD 614

  Fly   563 LHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCP 627
            |||:.||||||||||||||||||.||::||||||||||||||||||||||||||:||||||||||
  Rat   615 LHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCP 679

  Fly   628 TGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGAS 692
            ||:|||||||:|:|||||.:|||||||||||||||||:||.||||||||||||||||||||||||
  Rat   680 TGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGAS 744

  Fly   693 IFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            ||||||:|||||||||.|||||||||||||||||||||
  Rat   745 IFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	81/112 (72%)
		WD40	442..727	CDD:238121	257/284 (90%)
		WD40 repeat	447..486	CDD:293791	32/38 (84%)
		WD40 repeat	494..532	CDD:293791	34/37 (92%)
		WD40 repeat	537..573	CDD:293791	32/35 (91%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	27/32 (84%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
Tle3	XP_006243273.1	WD40 repeat	589..625	CDD:293791	32/35 (91%)
		WD40 repeat	632..667	CDD:293791	31/34 (91%)
		WD40 repeat	672..705	CDD:293791	27/32 (84%)
		WD40 repeat	713..747	CDD:293791	31/33 (94%)
		WD40 repeat	754..778	CDD:293791	22/23 (96%)
		TLE_N	9..143	CDD:397828	89/134 (66%)
		Herpes_BLLF1	<261..482	CDD:282904	80/239 (33%)
		WD40	494..779	CDD:238121	257/284 (90%)
		WD40 repeat	499..538	CDD:293791	32/38 (84%)
		WD40 repeat	546..584	CDD:293791	34/37 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2083
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	888	1.000	Inparanoid score	I373
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm63535
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880