DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and WDR5a

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_190535.1	Gene:	WDR5a / 824128	AraportID:	AT3G49660	Length:	317	Species:	Arabidopsis thaliana

Alignment Length:	287	Identity:	67/287 - (23%)
Similarity:	113/287 - (39%)	Gaps:	54/287 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 IRSVKLLPDGRTLIVGGEASNL---SIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCS 554
            :.|||...|||.|........:   :|..:..|......|.|........:|.|.|::...|...
plant    27 VSSVKFSSDGRLLASASADKTIRTYTINTINDPIAEPVQEFTGHENGISDVAFSSDARFIVSASD 91

  Fly   555 DGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQ---QH-- 614
            |..:.:||:....|::...|||:.|.|::.:|..:.:.:|..|.|||.||:..|:.|:   .|
plant    92 DKTLKLWDVETGSLIKTLIGHTNYAFCVNFNPQSNMIVSGSFDETVRIWDVTTGKCLKVLPAHSD 156

  Fly   615 -----DFS---SQIFS-------------LGYC------------------PTGDWLAVGMENSH 640
                 ||:   |.|.|             .|:|                  |.|.::.||..::.
plant   157 PVTAVDFNRDGSLIVSSSYDGLCRIWDSGTGHCVKTLIDDENPPVSFVRFSPNGKFILVGTLDNT 221

  Fly   641 VEVLHASKP---DKYQLHLH-ESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKE--T 699
            :.:.:.|..   ..|..|:: :.|:.|......||..||..:||.::.|.. ....:.|..|  |
plant   222 LRLWNISSAKFLKTYTGHVNAQYCISSAFSVTNGKRIVSGSEDNCVHMWEL-NSKKLLQKLEGHT 285

  Fly   700 SSVLSCDISTDDKYIVTGSGDKKATVY 726
            .:|::......:..|.:||.||...::
plant   286 ETVMNVACHPTENLIASGSLDKTVRIW 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	67/287 (23%)
		WD40 repeat	447..486	CDD:293791
		WD40 repeat	494..532	CDD:293791	10/40 (25%)
		WD40 repeat	537..573	CDD:293791	8/35 (23%)
		WD40 repeat	580..615	CDD:293791	12/44 (27%)
		WD40 repeat	620..653	CDD:293791	9/66 (14%)
		WD40 repeat	661..695	CDD:293791	8/33 (24%)
		WD40 repeat	702..726	CDD:293791	6/23 (26%)
WDR5a	NP_190535.1	WD40	16..312	CDD:238121	67/285 (24%)
		WD40 repeat	27..69	CDD:293791	10/41 (24%)
		WD40 repeat	75..111	CDD:293791	8/35 (23%)
		WD40 repeat	116..152	CDD:293791	12/35 (34%)
		WD40 repeat	159..194	CDD:293791	7/34 (21%)
		WD40 repeat	201..237	CDD:293791	5/35 (14%)
		WD40 repeat	245..282	CDD:293791	10/37 (27%)
		WD40 repeat	288..312	CDD:293791	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910