DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and TLE6

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001137458.1	Gene:	TLE6 / 79816	HGNCID:	30788	Length:	572	Species:	Homo sapiens

Alignment Length:	649	Identity:	173/649 - (26%)
Similarity:	280/649 - (43%)	Gaps:	143/649 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 QQVPGGPPQPMGALNPFGALGATMGLPH-GPQGLLNK---------------------------- 178
            |..|.|||:   :.:|...:..:...|. ..||:||:
Human     6 QPRPKGPPK---STSPCPGISNSESSPTLNYQGILNRLKQFPRFSPHFAAELESIYYSLHKIQQD 67

  Fly   179 PPEHHRPDIKPTG-----------LEGPAAAEERLRNSVSPADREKYRTRSPLDIENDSKRRKDE 232
            ..|||    |..|           |:|..:.|      ||||:     ..||    ...::.||:
Human    68 VAEHH----KQIGNVLQIVESCSQLQGFQSEE------VSPAE-----PASP----GTPQQVKDK 113

  Fly   233 KLQEDEGEKSDQDLVVDVANEMESHSPRPNGEHVSMEVR---DRE------SLNGERLEKPSSSG 288
            .||    |.|.:|:   :|........||.||....|.:   |:|      :|. |:|.: ..:|
Human   114 TLQ----ESSFEDI---MATRSSDWLRRPLGEDNQPETQLFWDKEPWFWHDTLT-EQLWR-IFAG 169

  Fly   289 IKQERPPSRSGSSSSRSTPSLKTKDMEKPGTPGAKARTPTPNAAAPAPGVNPKQMMPQGPPPAGY 353
            :..|                 |.|..::...||....:..|.:.  .||.:|      .|..|..
Human   170 VHDE-----------------KAKPRDRQQAPGLGQESKAPGSC--DPGTDP------CPEDAST 209

  Fly   354 PGAPYQRPADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQP 418
            |            |||.  |...||....|  .:.....:..|       |..:.......|..|
Human   210 P------------RPPE--ASSSPPEGSQD--RNTSWGVVQEP-------PGRASRFLQSISWDP 251

  Fly   419 VPFP-----PDALVG----VGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDIS- 473
            ..|.     ||||.|    :.:|....::..|:|||:|.|..||:.|::|:|.|:..:|||.::
Human   252 EDFEDAWKRPDALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTG 316

  Fly   474 -QPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGG-EASNLSIWDLASPTPRIKAELTSAAPA 536
             ...::.|.|.|.......::|:..|..:.|:|:.|| ..:::|:||||:|:..:|.:|..|...
Human   317 QVAEDRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 381

  Fly   537 CYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVR 601
            |.||..:.|:.:.|:..:.|.:.:|||.::.:||..:|:.||...|.:.  |..:||||.|..:|
Human   382 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVK--GYNIWTGGPDACLR 444

  Fly   602 SWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRF 666
            .||.|...:..::.|.|||.||.:.|..||:.:||.|....:...|...::.:...:|.:||::|
Human   445 CWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQKDSVILSVKF 509

  Fly   667 AACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            :..|:|:.|.|.|:.|..:..|.|..:|:..|.|.|..||:|::::.:|||||: .|:||::.|
Human   510 SPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVTGSGE-HASVYQITY 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	96/287 (33%)
		WD40 repeat	447..486	CDD:293791	14/40 (35%)
		WD40 repeat	494..532	CDD:293791	14/38 (37%)
		WD40 repeat	537..573	CDD:293791	11/35 (31%)
		WD40 repeat	580..615	CDD:293791	11/34 (32%)
		WD40 repeat	620..653	CDD:293791	10/32 (31%)
		WD40 repeat	661..695	CDD:293791	11/33 (33%)
		WD40 repeat	702..726	CDD:293791	10/23 (43%)
TLE6	NP_001137458.1	WD40 repeat	382..418	CDD:293791	11/35 (31%)
		WD 4	419..456		14/38 (37%)
		WD40 repeat	425..456	CDD:293791	11/32 (34%)
		WD 5	458..497		13/38 (34%)
		WD40 repeat	463..496	CDD:293791	10/32 (31%)
		WD 6	499..538		12/38 (32%)
		WD40 repeat	504..538	CDD:293791	11/33 (33%)
		WD 7	540..571		14/31 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..121		13/47 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..236		18/85 (21%)
		WD40	268..>568	CDD:225201	97/302 (32%)
		WD40	282..561	CDD:295369	92/280 (33%)
		WD 1	284..322		14/37 (38%)
		WD40 repeat	289..325	CDD:293791	11/35 (31%)
		WD 2	332..372		12/39 (31%)
		WD40 repeat	338..377	CDD:293791	14/38 (37%)
		WD 3	377..416		11/38 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146174
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.800