DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and SPAG16

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_078808.3	Gene:	SPAG16 / 79582	HGNCID:	23225	Length:	631	Species:	Homo sapiens

Alignment Length:	722	Identity:	126/722 - (17%)
Similarity:	211/722 - (29%)	Gaps:	336/722 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTL 90
            :.|.:|::|.:|.:..:..|..|..||.|:...::.||.. ||.:..:..|.|         :||
Human   183 EDLLKIQKERDFHRMHHKRIVQEKNKLINDLKGLKLHYAS-YEPTIRVLHEKH---------HTL 237

  Fly    91 INQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQHGIQQLLQQI---HAQQVPGGPPQP 152
            :           ::::|.::||.|         ::|  |..|:|:.|:::   |:.
Human   238 L-----------KEKMLTSLERDK---------VVG--QISGLQETLKKLQRGHSY--------- 271

  Fly   153 MGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIKPTGLEGPAAAEERLRNSVSPADREKYRTR 217
                             ||||..:    :|.|.  |....|||  .::.||.:     ||:.:.:
Human   272 -----------------HGPQIKV----DHSRE--KENAPEGP--TQKGLREA-----REQNKCK 306

  Fly   218 SPLDIENDSKRRKDEKLQEDEGEKSDQDLVVDVANEMESHSPRPNGEHVSMEVRDRESLNGERLE 282
            :.:                 :|...|.:..:|:       .|.||     :.| .:|||:..:.:
Human   307 TKM-----------------KGNTKDSEFPIDM-------QPNPN-----LNV-SKESLSPAKFD 341

  Fly   283 KPSSSGIKQERPPSRSGSSSSRSTPSLKTKDM----EKPGTPGAKARTPTPNAAAPAPGVNPKQM 343
                                      .|.|::    |.|                    |:...|
Human   342 --------------------------YKLKNIFRLHELP--------------------VSCVSM 360

  Fly   344 MPQGPPPAGYPGAPYQRPADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYSF 408
            .                                                 ||...|..
Human   361 Q-------------------------------------------------PHKDILVS------- 369

  Fly   409 HMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDIS 473
              .||..|..|         :|:|:              |.|.:   |.:.:|.       | :|
Human   370 --CGEDRLWKV---------LGLPK--------------CNVLL---TGFGHTD-------W-LS 398

  Fly   474 QPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACY 538
                       ||.          ..|.|..|......:.:.:|||.      |.:       |
Human   399 -----------DCC----------FHPSGDKLATSSGDTTVKLWDLC------KGD-------C- 428

  Fly   539 ALAISPDSKVCFSCC--SDGNIA----------VWDLHNEILVRQFQGHTDGASCIDISPDGSRL 591
            .|.....|:..:||.  |.||..          :||:::|.......||||..:.|:..|..:.|
Human   429 ILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTL 493

  Fly   592 WTGGLDNTVRSWDLREGRQLQ-----QHDFSSQIF------------------------------ 621
            .|...|.|:..||.|.|...|     .|..:..||
Human   494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSI 558

  Fly   622 SLGYCP--------TGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGK 678
            .:|..|        :|..||....|..:.:|.....:.::|..||:...::.|:..|:...|.|.
Human   559 DIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGS 623

  Fly   679 DNLLNAW 685
            |..:..|
Human   624 DGTVRTW 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	21/97 (22%)
		WD40	442..727	CDD:238121	60/299 (20%)
		WD40 repeat	447..486	CDD:293791	6/38 (16%)
		WD40 repeat	494..532	CDD:293791	7/37 (19%)
		WD40 repeat	537..573	CDD:293791	11/47 (23%)
		WD40 repeat	580..615	CDD:293791	11/39 (28%)
		WD40 repeat	620..653	CDD:293791	9/70 (13%)
		WD40 repeat	661..695	CDD:293791	6/25 (24%)
		WD40 repeat	702..726	CDD:293791
SPAG16	NP_078808.3	Prefoldin	160..271	CDD:298833	27/119 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..332		22/134 (16%)
		WD40	<341..631	CDD:225201	75/463 (16%)
		WD40	344..631	CDD:238121	74/434 (17%)
		WD 1	350..389		15/142 (11%)
		WD40 repeat	355..392	CDD:293791	14/120 (12%)
		WD 2	392..431		13/81 (16%)
		WD40 repeat	398..434	CDD:293791	12/70 (17%)
		WD 3	434..473		9/38 (24%)
		WD40 repeat	439..475	CDD:293791	8/35 (23%)
		WD 4	476..515		14/38 (37%)
		WD40 repeat	482..516	CDD:293791	11/33 (33%)
		WD 5	518..557		3/38 (8%)
		WD40 repeat	523..559	CDD:293791	2/35 (6%)
		WD 6	560..600		7/39 (18%)
		WD40 repeat	565..600	CDD:293791	5/34 (15%)
		WD 7	601..630		7/28 (25%)
		WD40 repeat	607..630	CDD:293791	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910