DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and wdsub1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001071237.1	Gene:	wdsub1 / 777721	ZFINID:	ZDB-GENE-061110-97	Length:	487	Species:	Danio rerio

Alignment Length:	326	Identity:	77/326 - (23%)
Similarity:	129/326 - (39%)	Gaps:	55/326 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 VPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQ 483
            :||.|  |.|.|...|....:........|:   ::.|..|::...|.::. .:..|| ::||
Zfish    45 LPFSP--LSGHGYGVHCCCFSACGQYLASCS---TDATTMVWSMDTGEIEA-VLEHPG-RSPV-- 100

  Fly   484 LDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKV 548
                      |.....||...|:.||...::::||..|.|.|....:...  :..|.:.:|..::
Zfish   101 ----------RVCAFSPDSSHLVSGGSDGSIALWDFTSRTLRRTGVVNDT--SIVACSFTPCGQM 153

  Fly   549 CFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISP------DGS---RLWTGGLDNTVRSWD 604
            ..:..:.|::.:|||:...|..:...|..|.||...:|      ||.   ||.:.|.|:.::.|.
Zfish   154 FITGSTYGDLRLWDLNMNHLHAEKNAHDLGVSCAQFAPKMMKGTDGCVQFRLASCGQDSLLKIWI 218

  Fly   605 L----REGRQLQ-QHDFSSQ---IFSLGYCPTGDWLAVGMENSHVEVLHASKPDK----YQLHLH 657
            :    ..|.::| .|..:.|   :.|..|.|.|..|..|..:..|.|..|   |:    |.||.|
Zfish   219 VSLLPSAGIKMQLAHTLTGQSAPVLSCAYSPDGQMLVSGSVDKTVTVYQA---DEGVLLYTLHQH 280

  Fly   658 ESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKK 722
            :..|.:..|:.......:...|..:|.||...|:|. |.|..         .|:|...:.:..:|
Zfish   281 DRYVTACAFSPTAPLIATGSMDKSVNIWRMEEGSSA-QGKSL---------PDEKAAFSNTEGRK 335

  Fly   723 A 723
            |
Zfish   336 A 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	70/303 (23%)
		WD40 repeat	447..486	CDD:293791	8/38 (21%)
		WD40 repeat	494..532	CDD:293791	11/37 (30%)
		WD40 repeat	537..573	CDD:293791	7/35 (20%)
		WD40 repeat	580..615	CDD:293791	12/48 (25%)
		WD40 repeat	620..653	CDD:293791	10/36 (28%)
		WD40 repeat	661..695	CDD:293791	8/33 (24%)
		WD40 repeat	702..726	CDD:293791	4/22 (18%)
wdsub1	NP_001071237.1	WD40	4..309	CDD:238121	67/287 (23%)
		WD 1	10..47		0/1 (0%)
		WD40 repeat	17..52	CDD:293791	4/8 (50%)
		WD40	50..>371	CDD:225201	74/319 (23%)
		WD 2	52..93		7/44 (16%)
		WD40 repeat	58..96	CDD:293791	5/41 (12%)
		WD 3	95..134		15/51 (29%)
		WD40 repeat	100..134	CDD:293791	12/45 (27%)
		WD 4	137..176		7/40 (18%)
		WD40 repeat	143..178	CDD:293791	7/34 (21%)
		WD 5	179..227		12/47 (26%)
		WD40 repeat	184..236	CDD:293791	13/51 (25%)
		WD 6	237..276		11/41 (27%)
		WD40 repeat	242..278	CDD:293791	11/38 (29%)
		WD 7	279..318		9/39 (23%)
		WD40 repeat	284..308	CDD:293791	4/23 (17%)
		SAM_WDSUB1	343..414	CDD:188904
		SAM	344..409	CDD:197735
		RING	418..483	CDD:302633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910