DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Katnb1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_083081.2	Gene:	Katnb1 / 74187	MGIID:	1921437	Length:	658	Species:	Mus musculus

Alignment Length:	191	Identity:	49/191 - (25%)
Similarity:	88/191 - (46%)	Gaps:	30/191 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 IPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGC-VKVWDISQP-------GNKNPVSQLDCL 487
            |..||..:::|..|:.        ..:.:.|||..| |.:|.|::|       |:.:||
Mouse    16 IVAHASNVSSLVLGKA--------SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV------ 66

  Fly   488 QRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSC 552
                  .||:|......::.|.::.::.:|||.: ...::..:...|..| :|...|..:...|.
Mouse    67 ------ESVRLNTPEELIVAGSQSGSIRVWDLEA-AKILRTLMGHKANIC-SLDFHPYGEFVASG 123

  Fly   553 CSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQ 613
            ..|.||.:||:..:..|.:::||:....|:..||||..|.:...|:||:.|||..|:.:.:
Mouse   124 SQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSE 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	45/180 (25%)
		WD40 repeat	447..486	CDD:293791	11/46 (24%)
		WD40 repeat	494..532	CDD:293791	7/37 (19%)
		WD40 repeat	537..573	CDD:293791	10/35 (29%)
		WD40 repeat	580..615	CDD:293791	13/34 (38%)
		WD40 repeat	620..653	CDD:293791
		WD40 repeat	661..695	CDD:293791
		WD40 repeat	702..726	CDD:293791
Katnb1	NP_083081.2	Interaction with centrosomes. /evidence=ECO:0000250	1..300		49/191 (26%)
		Interaction with dynein	1..284		49/191 (26%)
		WD40	7..257	CDD:238121	49/191 (26%)
		WD40 repeat	67..103	CDD:293791	7/36 (19%)
		WD40 repeat	108..144	CDD:293791	10/36 (28%)
		WD40 repeat	151..186	CDD:293791	13/34 (38%)
		WD40 repeat	192..228	CDD:293791
		WD40 repeat	234..261	CDD:293791
		Interaction with PAFAH1B1. /evidence=ECO:0000269\|PubMed:16203747	285..437
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..419
		MARCKS	<367..465	CDD:366900
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..458
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000269\|PubMed:16203747	436..658
		Katanin_con80	500..651	CDD:372820
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910