DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and TLE4

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_011517254.1	Gene:	TLE4 / 7091	HGNCID:	11840	Length:	872	Species:	Homo sapiens

Alignment Length:	912	Identity:	496/912 - (54%)
Similarity:	570/912 - (62%)	Gaps:	229/912 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |||. .||||.  ..|..|.||||:::.:||||||.||||||||:|||||||::|||||||||||
Human     8 MYPQ-TRHPAP--HQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM 69

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQ- 129
            |||||||||:|||||.||.||||.:..|::|||..:|||||:|||||||||||.|||.|||.::
Human    70 YYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGEKKN 134

  Fly   130 -------------QH-GI-------------------QQLLQQIHAQQVPGGP----PQPMG--- 154
                         :| |:                   ||.||..|.....|.|    |.|.|
Human   135 KSDTPGSLKSNIGRHVGVEENKPNLERRKKGPLFFSEQQQLQAQHLSHGHGLPVPLTPHPSGLQP 199

  Fly   155 -ALNPFG----------ALGATMGLPHGPQGLLNKPPEHH-------RPDIKPTGLEGPAAAEER 201
             |:.|.|          |||....||      :....:||       |..||
Human   200 PAIPPIGSSAGLLALSSALGGQSHLP------IKDEKKHHDNDHQRDRDSIK------------- 245

  Fly   202 LRNSVSPA----DREKYRTRSPLDIENDSKRRKDEKLQ-----EDEGEKSDQDLVVDVANEMES- 256
             .:||||:    ..||:|..:  |..::||::|.|:.:     :.:|||||.:|||||:||..|
Human   246 -SSSVSPSASFRGAEKHRNSA--DYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSS 307

  Fly   257 ------HSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDM- 314
                  ||||.||            |:..||       :|::.|.|.:..:||.||||.|:|::
Human   308 PRGSPAHSPRENG------------LDKTRL-------LKKDAPISPASIASSSSTPSSKSKELS 353

  Fly   315 ----------------------------------EKPGTPGAKARTPTPNAAAPAPGVN------ 339
                                              ||..||.:|:.||||...||.||.|
Human   354 LKRDMGKLSETRLSEDEQCTLGLQRWFCRLWFMNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLR 418

  Fly   340 PKQMMPQG------------------PPPAGY------------PGAPYQRPADPYQRPP----- 369
            |....|.|                  |.|.|.            |||.|   |..:...|
Human   419 PVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAY---AGLHNISPQMSAA 480

  Fly   370 -----SDPAYGRPPPMPYDPHAHVRTNGI-PHPSALTGGKP------------------------ 404
                 :..||||.|.:.:|||.|:|...| |:.:.:.||||
Human   481 AAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPTKCFYHLRAFPGNELEMELPRDTH 545

  Fly   405 -AYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVK 468
             |||||::.:|.:||||||||||:|.||||||||||||:||||||||||||||::||||||||||
Human   546 RAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVK 610

  Fly   469 VWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSA 533
            |||||.||||:||||||||.|||||||.:|||||||||||||||.|||||||:|||||||||||:
Human   611 VWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSS 675

  Fly   534 APACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDN 598
            ||||||||||||||||||||||||||||||||:.||||||||||||||||||.||::||||||||
Human   676 APACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDN 740

  Fly   599 TVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLS 663
            ||||||||||||||||||:||||||||||||:|||||||||:|||||.:||||||||||||||||
Human   741 TVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLS 805

  Fly   664 LRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEV 728
            |:||.||||||||||||||||||||||||||||||:|||||||||.|||||||||||||||||||
Human   806 LKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 870

  Fly   729 IY 730
            ||
Human   871 IY 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	81/112 (72%)
		WD40	442..727	CDD:238121	259/284 (91%)
		WD40 repeat	447..486	CDD:293791	34/38 (89%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	33/35 (94%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	28/32 (88%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
TLE4	XP_011517254.1	TLE_N	8..133	CDD:281857	91/127 (72%)
		WD40	<578..870	CDD:225201	266/291 (91%)
		WD40	585..869	CDD:238121	259/283 (92%)
		WD40 repeat	589..628	CDD:293791	34/38 (89%)
		WD40 repeat	636..674	CDD:293791	33/37 (89%)
		WD40 repeat	679..715	CDD:293791	33/35 (94%)
		WD40 repeat	722..757	CDD:293791	31/34 (91%)
		WD40 repeat	762..795	CDD:293791	28/32 (88%)
		WD40 repeat	803..837	CDD:293791	31/33 (94%)
		WD40 repeat	844..868	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2128
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	891	1.000	Inparanoid score	I393
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm40722
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	LDO	PTHR10814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4593
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870