DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and TLE3

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_011520278.1	Gene:	TLE3 / 7090	HGNCID:	11839	Length:	782	Species:	Homo sapiens

Alignment Length:	813	Identity:	489/813 - (60%)
Similarity:	566/813 - (69%)	Gaps:	114/813 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |||.. ||||...|...| .|||:|::.:|||:||.||||||||:|:|.:||:||||||||||||
Human     1 MYPQG-RHPAPHQPGQPG-FKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVM 63

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQ 130
            |||||||||:||||||||||||||::.|::|||..:|||||.|||||||||||.|||.|||.:..
Human    64 YYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGL 128

  Fly   131 HGI---QQLLQQIHAQQVPGG-----PPQPMGALNPFG---ALGATMGL----PHGPQGLLNKPP 180
            ..:   ||.||..|......|     ||.|.| |.|.|   ..|::.||    ..|.|..|....
Human   129 PNLPLTQQQLQAQHLSHATHGPPVQLPPHPSG-LQPPGIPPVTGSSSGLLALGALGSQAHLTVKD 192

  Fly   181 E--HHRPDIKPTGLEGPAAAEERLRNSVSPAD--REKYRTRSPLDIENDSKRRKDEKLQ-----E 236
            |  ||..|.:        ..|....|||||::  |...:.|...|...::|:||.|:..     :
Human   193 EKNHHELDHR--------ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYD 249

  Fly   237 DEGEKSDQDLVVDVANE-------MESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERP 294
            .:|:||| ||||||:||       ..:|||..||                 |:|..|  :|::.|
Human   250 SDGDKSD-DLVVDVSNEDPATPRVSPAHSPPENG-----------------LDKARS--LKKDAP 294

  Fly   295 PSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPGVNPK---QMMPQGPP---P 350
            .|.:..:||.||||.||||:   :|..|||.|:.||||...||.||.:..   :.||..||   |
Human   295 TSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDP 359

  Fly   351 AGYPGAPYQRP-------ADPYQR----------------------PP--------SDPAYGRPP 378
            .|...:..:.|       |.|:..                      ||        :..||||.|
Human   360 IGIMASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSP 424

  Fly   379 -----PMPYDPHAHVRTNGIPHP-SALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQ 437
                 .:.:|||..:|..|:|.. :::.|||||||||::.:|.:||||||.|||.|.||||||||
Human   425 MVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQ 489

  Fly   438 INTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDG 502
            |||||||||||||||||||::||||||||||:|||||||:|:|:||||||.|||||||.||||||
Human   490 INTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDG 554

  Fly   503 RTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEI 567
            ||||||||||.|:|||||||||||||||||:||||||||||||:|||||||||||||||||||:.
Human   555 RTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQT 619

  Fly   568 LVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWL 632
            ||||||||||||||||||.||::||||||||||||||||||||||||||:||||||||||||:||
Human   620 LVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWL 684

  Fly   633 AVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSK 697
            |||||:|:|||||.:|||||||||||||||||:||.|||||||||||||||||||||||||||||
Human   685 AVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK 749

  Fly   698 ETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            |:|||||||||.|||||||||||||||||||||
Human   750 ESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	81/112 (72%)
		WD40	442..727	CDD:238121	257/284 (90%)
		WD40 repeat	447..486	CDD:293791	32/38 (84%)
		WD40 repeat	494..532	CDD:293791	34/37 (92%)
		WD40 repeat	537..573	CDD:293791	32/35 (91%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	27/32 (84%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
TLE3	XP_011520278.1	TLE_N	9..143	CDD:397828	89/134 (66%)
		WD40	494..779	CDD:238121	257/284 (90%)
		WD40 repeat	499..538	CDD:293791	32/38 (84%)
		WD40 repeat	546..584	CDD:293791	34/37 (92%)
		WD40 repeat	589..625	CDD:293791	32/35 (91%)
		WD40 repeat	632..667	CDD:293791	31/34 (91%)
		WD40 repeat	672..705	CDD:293791	27/32 (84%)
		WD40 repeat	713..747	CDD:293791	31/33 (94%)
		WD40 repeat	754..778	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2128
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	891	1.000	Inparanoid score	I393
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm40722
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4593
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870