DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and TLE2

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001287775.1	Gene:	TLE2 / 7089	HGNCID:	11838	Length:	744	Species:	Homo sapiens

Alignment Length:	793	Identity:	447/793 - (56%)
Similarity:	525/793 - (66%)	Gaps:	112/793 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQG-PIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYV 64
            |||.. |||.   |...| |.||:|.:..:||||||.||||||||:|||||||::||||||||||
Human     1 MYPQG-RHPT---PLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV 61

  Fly    65 MYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQ 129
            ||||||||||:|||||.||.|||:.:..|::|||..:||||||||||||||||:.|||.:||.||
Human    62 MYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQQ 126

  Fly   130 QHGIQQLLQQIHAQQVPGGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIKPTGLEG 194
               :|.|..  ||..||..|       .|.|.:|.:      ..|||              .|.|
Human   127 ---LQPLSH--HAPPVPLTP-------RPAGLVGGS------ATGLL--------------ALSG 159

  Fly   195 PAAAEERLRNSV-----------SPADREKYRTRSPLDIEN------------DSKRRKDEK--- 233
            ..||:.:|..:|           |..:|...|:.||...|:            ..|:|.|||
Human   160 ALAAQAQLAAAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPS 224

  Fly   234 --LQEDEGEKSDQDLVVDVANEMESHSP--RPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERP 294
              .:.|| :|||.:||||.....|..||  .|.|: |.:.:..|..|........||.|....|.
Human   225 GPYESDE-DKSDYNLVVDEDQPSEPPSPATTPCGK-VPICIPARRDLVDSPASLASSLGSPLPRA 287

  Fly   295 PSRSGSSSSRSTPSLKTKDMEKPGTPGAKARTPTPN--------AAAPAPGVNP---KQMMPQGP 348
            .....:....|||:.|:.|    .:|...|.||.|:        ||.|||..:.   :..:....
Human   288 KELILNDLPASTPASKSCD----SSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSS 348

  Fly   349 P-------------------PAGYPGAPYQRPADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIP 394
            |                   |:.|... :..|     :..|...|||.|.|.::.|.|:|.:.:.
Human   349 PFTTSFSLGSHSTLNGDLSVPSSYVSL-HLSP-----QVSSSVVYGRSPVMAFESHPHLRGSSVS 407

  Fly   395 H--PSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTK 457
            .  || :.|||||||||::.:|.:||||||.|||||.||||||||::||:|||||||||||..|:
Human   408 SSLPS-IPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQ 471

  Fly   458 YVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASP 522
            :|||||||||||||:.|||.|.||:|||||.|||||||.|||||||:||||||||.|||||||:|
Human   472 HVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAP 536

  Fly   523 TPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPD 587
            ||||||||||:||||||||:|||:||||||||||||.||||.|:.:|||||||||||||||||..
Human   537 TPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDY 601

  Fly   588 GSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKY 652
            |:||||||||||||.||||||||||||||||||||||:||..||||||||:|:||:||..||:||
Human   602 GTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKY 666

  Fly   653 QLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVTG 717
            ||||||||||||:||:||:|||||||||||||||||||||||||||:|||||||||.::||||||
Human   667 QLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTG 731

  Fly   718 SGDKKATVYEVIY 730
            |||||||||||:|
Human   732 SGDKKATVYEVVY 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	80/113 (71%)
		WD40	442..727	CDD:238121	241/284 (85%)
		WD40 repeat	447..486	CDD:293791	29/38 (76%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	28/35 (80%)
		WD40 repeat	580..615	CDD:293791	30/34 (88%)
		WD40 repeat	620..653	CDD:293791	23/32 (72%)
		WD40 repeat	661..695	CDD:293791	30/33 (91%)
		WD40 repeat	702..726	CDD:293791	20/23 (87%)
TLE2	NP_001287775.1	TLE_N	1..128	CDD:281857	90/133 (68%)
		GP domain. /evidence=ECO:0000250\|UniProtKB:Q04724	129..192		20/91 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..233		13/53 (25%)
		CcN domain. /evidence=ECO:0000250\|UniProtKB:Q04724	193..255		20/62 (32%)
		Nuclear localization signal. /evidence=ECO:0000255	215..218		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		7/19 (37%)
		SP domain. /evidence=ECO:0000250\|UniProtKB:Q04724	256..424		46/179 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..323		10/29 (34%)
		WD40	<456..742	CDD:225201	242/285 (85%)
		WD 1	456..494		29/37 (78%)
		WD40	457..741	CDD:295369	241/283 (85%)
		WD40 repeat	461..500	CDD:293791	29/38 (76%)
		WD 2	502..541		33/38 (87%)
		WD40 repeat	508..546	CDD:293791	33/37 (89%)
		WD 3	546..585		30/38 (79%)
		WD40 repeat	551..587	CDD:293791	28/35 (80%)
		WD 4	588..627		34/38 (89%)
		WD40 repeat	594..629	CDD:293791	30/34 (88%)
		WD40 repeat	634..667	CDD:293791	23/32 (72%)
		WD 5	670..709		35/38 (92%)
		WD40 repeat	675..709	CDD:293791	30/33 (91%)
		WD 6	711..743		27/31 (87%)
		WD40 repeat	716..740	CDD:293791	20/23 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3264
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	891	1.000	Inparanoid score	I393
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm40722
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830