DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and TLE1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_005252208.1	Gene:	TLE1 / 7088	HGNCID:	11837	Length:	814	Species:	Homo sapiens

Alignment Length:	851	Identity:	492/851 - (57%)
Similarity:	568/851 - (66%)	Gaps:	158/851 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPS---PVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRH 62
            |:|.   |..|.|||     .|.||||.::|:||||||.||||||||:|||||||::||||||||
Human     1 MFPQSRHPTPHQAAG-----QPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60

  Fly    63 YVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGH 127
            ||||||||||||:||||||||||||||:..|::|||..:|||||.|||||||||||.|||.|||.
Human    61 YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGV 125

  Fly   128 QQQHGIQQLLQQIHAQQVP--GGPPQPM----GALNPFG--ALGATMGL------PHGPQGLLNK 178
            :...|:....||:.||.:.  .|||.|:    ..|.|.|  .||.:.||      ..|...|..|
Human   126 RGLPGLPPTQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK 190

  Fly   179 ------PPEHHRPDIKPTGLEGPAAAEERLRNSVSPADREKYRTRSPLDIENDSKRR----KDEK 233
                  ..|||| |.:| |........:.||.:    |:   |...| :..||.|:|    ||..
Human   191 DDKKHHDAEHHR-DREP-GTSNSLLVPDSLRGT----DK---RRNGP-EFSNDIKKRKVDDKDSS 245

  Fly   234 LQEDEGEKSDQDLVVDVANEMES-------HSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQ 291
            ..:.:|:|||.:|||||:||..|       ||||.||            ::..||       :|:
Human   246 HYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENG------------IDKNRL-------LKK 291

  Fly   292 ERPPSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPG---------------- 337
            :...|.:.::||.|:.|||:|:|   ||..||..|:.||||.:..|.||
Human   292 DASSSPASTASSASSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPA 356

  Fly   338 VNP----------KQMMP----------------------------------QGPPPAGY----- 353
            ::|          .:::|                                  .||.||.:
Human   357 IDPLVNQAGLDFHLELVPGNGKFGLKEKSWILSRKSSFEIKSAAGLRTPLAVPGPYPAPFGMVPH 421

  Fly   354 ---------PGAPYQRPADPYQRPP---------SDPAYGRPPPMPYDPHAHVRTNGI-PHPSAL 399
                     |||.|   |..:...|         :..||||.|.:.:||..|:|...| |:.:.:
Human   422 AGMNGELTSPGAAY---ASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGI 483

  Fly   400 TGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGK 464
            .|||||||||:..:|.:||||||||||:|.||||||||||||:||||||||||||||::||||||
Human   484 PGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK 548

  Fly   465 GCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAE 529
            |||||||||.||||:||||||||.|||||||.||||||.|||||||||.|||||||:||||||||
Human   549 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAE 613

  Fly   530 LTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTG 594
            |||:||||||||||||||||||||||||||||||||:.||||||||||||||||||.||::||||
Human   614 LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTG 678

  Fly   595 GLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHES 659
            ||||||||||||||||||||||:||||||||||||:|||||||:|:|||||.:||||||||||||
Human   679 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHES 743

  Fly   660 CVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKAT 724
            |||||:||.||||||||||||||||||||||||||||||:|||||||||.|||||||||||||||
Human   744 CVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKAT 808

  Fly   725 VYEVIY 730
            ||||||
Human   809 VYEVIY 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	86/112 (77%)
		WD40	442..727	CDD:238121	258/284 (91%)
		WD40 repeat	447..486	CDD:293791	34/38 (89%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	33/35 (94%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	27/32 (84%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
TLE1	XP_005252208.1	TLE_N	1..143	CDD:281857	99/146 (68%)
		WD40	<520..812	CDD:225201	265/291 (91%)
		WD40	527..811	CDD:238121	258/283 (91%)
		WD40 repeat	531..570	CDD:293791	34/38 (89%)
		WD40 repeat	578..616	CDD:293791	33/37 (89%)
		WD40 repeat	621..657	CDD:293791	33/35 (94%)
		WD40 repeat	664..699	CDD:293791	31/34 (91%)
		WD40 repeat	704..737	CDD:293791	27/32 (84%)
		WD40 repeat	745..779	CDD:293791	31/33 (94%)
		WD40 repeat	786..810	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2128
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	891	1.000	Inparanoid score	I393
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm40722
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840