DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and tle2c

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_009297193.1	Gene:	tle2c / 692261	ZFINID:	ZDB-GENE-060512-84	Length:	353	Species:	Danio rerio

Alignment Length:	408	Identity:	156/408 - (38%)
Similarity:	198/408 - (48%)	Gaps:	86/408 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPI-------KFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTE 58
            |||    |..     ||.|:       |||:.:||:.|||||...||||||:|||||||::||||
Zfish     6 MYP----HGR-----PQAPLVSGHAGMKFTVLETLDHIKEEFQLFQAQYHSLKLECEKLASEKTE 61

  Fly    59 MQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNL 123
            |.|||:||||||||||:||.||.||.|||:.:..|::|.|..:||.||.|||||:|.|:|.|||.
Zfish    62 MHRHYIMYYEMSYGLNIEMQKQAEIVKRLSAICTQIIPLLSQEHQHQVAQAVERSKHVSMAELNA 126

  Fly   124 IIGHQQQHGIQQLLQQIHAQQVPGGP--PQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRP- 185
            |||.... |:||...|..:...||.|  |.|.|.     :|||..||...| |....|| |..|
Zfish   127 IIGFDAL-GLQQQQFQHLSHHAPGFPMTPHPSGL-----SLGAGAGLMALP-GAFPFPP-HLMPK 183

  Fly   186 -DIK-PTGLEGPAAAEERLRNSVSPADREKYRTRSPL-----------DIENDSKRRKDE--KLQ 235
             |:. |..||....|..| ..|.||........|..|           |:  ||||...:  :.:
Zfish   184 DDLSHPEALESRDGAANR-SGSGSPVGHRSVGLRLALPPPSSSSSSHSDL--DSKRSGSDAGRTR 245

  Fly   236 EDEGEKSDQDLVVDVANEMESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERPPSRSGS 300
            .:.|.|::..|..|.|.| :|.||    ..||....:...||        ||.:..:. |||.||
Zfish   246 RESGNKNEDTLRRDGAKE-KSLSP----AGVSPRSTEGNGLN--------SSPVLCKN-PSREGS 296

  Fly   301 SSSRSTPSLKTKDMEKPGTPGAKARTPT-PNAAAPAPGVNPKQMMPQGPPPAGYPGAPYQRPADP 364
            ||..|          :|.:| |..::|| ....:|:|..:.:.:.|      |.|.||
Zfish   297 SSPPS----------QPRSP-ALCKSPTQEKVRSPSPSASHESLSP------GSPAAP------- 337

  Fly   365 YQRPPSDPAYGRPPPMPY 382
              ||.|..|.|..|.:.:
Zfish   338 --RPLSSSARGPSPALKH 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	71/119 (60%)
		WD40	442..727	CDD:238121
		WD40 repeat	447..486	CDD:293791
		WD40 repeat	494..532	CDD:293791
		WD40 repeat	537..573	CDD:293791
		WD40 repeat	580..615	CDD:293791
		WD40 repeat	620..653	CDD:293791
		WD40 repeat	661..695	CDD:293791
		WD40 repeat	702..726	CDD:293791
tle2c	XP_009297193.1	TLE_N	6..143	CDD:281857	82/146 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3389
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910