DRSC/TRiP Functional Genomics Resources

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Protein Alignment gro and TBL1X

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001132938.1 Gene:TBL1X / 6907 HGNCID:11585 Length:577 Species:Homo sapiens


Alignment Length:274 Identity:71/274 - (25%)
Similarity:116/274 - (42%) Gaps:49/274 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   465 GCVKVWDISQPGN--------KNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLAS 521
            |..::|  ::.||        |.|:..|...::.|||.|..:  |..|:          |||  :
Human   310 GFARIW--TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV--DKTTI----------IWD--A 358

  Fly   522 PTPRIKAELT-SAAPACYALAISPDSKVCF-SCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDI 584
            .|...|.:.. .:||   ||.:...:...| ||.:|..|.|..|..:..|:.|||||:..:.|..
Human   359 HTGEAKQQFPFHSAP---ALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420

  Fly   585 SPDGSRLWTGGLDNTVRSWDLREG---RQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHA 646
            .|.|..|.:...|.|::.|.:::.   ..||.|  :.:|:::.:.|||.  |....||::.:..|
Human   421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAH--NKEIYTIKWSPTGP--ATSNPNSNIMLASA 481

  Fly   647 SKPDKYQL---------HL---HESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKET 699
            |.....:|         |.   |:..|.|:.|:..||:..|...|..::.|.|..|..:...:.|
Human   482 SFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGT 546

  Fly   700 SSVLS-CDISTDDK 712
            ..:.. |..:..||
Human   547 GGIFEVCWNARGDK 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 71/274 (26%)
WD40 repeat 447..486 CDD:293791 7/28 (25%)
WD40 repeat 494..532 CDD:293791 8/38 (21%)
WD40 repeat 537..573 CDD:293791 10/36 (28%)
WD40 repeat 580..615 CDD:293791 9/37 (24%)
WD40 repeat 620..653 CDD:293791 9/32 (28%)
WD40 repeat 661..695 CDD:293791 10/33 (30%)
WD40 repeat 702..726 CDD:293791 3/12 (25%)
TBL1XNP_001132938.1 LisH 57..83 CDD:285685
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..202
WD40 215..577 CDD:225201 71/274 (26%)
WD40 227..533 CDD:238121 64/245 (26%)
WD 1 230..269
WD40 repeat 235..282 CDD:293791
WD 2 286..325 4/16 (25%)
WD40 repeat 292..327 CDD:293791 4/18 (22%)
WD 3 327..366 14/52 (27%)
WD40 repeat 332..368 CDD:293791 12/49 (24%)
WD 4 369..409 12/42 (29%)
WD40 repeat 375..409 CDD:293791 9/33 (27%)
WD 5 410..449 10/38 (26%)
WD40 repeat 415..451 CDD:293791 7/35 (20%)
WD 6 452..500 11/51 (22%)
WD40 repeat 457..502 CDD:293791 11/46 (24%)
WD 7 503..542 11/38 (29%)
WD40 repeat 508..532 CDD:293791 7/23 (30%)
WD 8 544..576 4/17 (24%)
WD40 repeat 549..572 CDD:293791 3/12 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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